Results 61 to 70 of about 2,764 (156)

Cytolethal Distending Toxin: A Unique Variation on the AB Toxin Paradigm [PDF]

New Journal of Science, 2014
Some of the most potent toxins produced by plants and bacteria are members of a large family known as the AB toxins. AB toxins are generally characterized by a heterogenous complex consisting of two protein chains arranged in various monomeric or polymeric configurations. The newest class within this superfamily is the cytolethal distending toxin (Cdt).
openaire   +1 more source

Probiotics Cancer Interaction, Prevention, and Therapy

Immunity, Inflammation and Disease, Volume 14, Issue 5, May 2026.
ABSTRACT Cancer is a significant global health concern and ranks as the second most common cause of death on a worldwide scale. A combination of hereditary and lifestyle variables, such as diet, smoking, alcohol consumption, physical exercise, and the gut microbiota, impacts cancer development. Dysbiosis, an imbalance in gut microorganisms, can promote
Mostafa Saebi, Amir Hossein Barjasteh, Mahmoud Mahmoudi, Ramiar Kamal Kheder, Setayesh Ramazanpour, Negar Ebadpour, Afsane Fadaee, Seyed‐Alireza Esmaeili   +7 more
wiley   +1 more source

Bacterial Infections Role in Gynecological Cancers Development: Narrative Review

Cancer Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background Gynecological cancers are among the most common cancers in women that affect female reproductive organs. The most common gynecological cancers are ovarian, cervical, uterine/endometrial, vaginal, and vulvar cancer. Women's reproductive organs have a dynamic and relative microbial balance.
Robab Azargun, Maryam Azargoon, Zahra Asefy, Mina Yekani, Vahideh Tarhriz, Fatemeh Yeganeh, Mohammad Yousef Memar, Shirin Eyvazi   +7 more
wiley   +1 more source

Alteration of homeostasis in pre-osteoclasts induced by Aggregatibacter actinomycetemcomitans CDT

Frontiers in Cellular and Infection Microbiology, 2016
The dysbiotic microbiota associated with aggressive periodontitis includes Aggregatibacter actinomycetemcomitans, the only oral species known to produce a cytolethal distending toxin (AaCDT). Given that CDT alters the cytokine profile in monocytic cells,
Dione eKawamoto, Ellen Sayuri Ando-Sugimoto, Bruno eBueno-Silva, Joseph M. DiRienzo, Marcia Pinto Alves Mayer   +4 more
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The genome and stage‐specific transcriptomes of the carrot weevil, Listronotus oregonensis, reveal adaptive mechanisms for host specialisation and symbiotic interactions

Insect Molecular Biology, Volume 35, Issue 2, Page 126-138, April 2026.
Comprehensive genome and stage‐specific transcriptomes reveal 14,637 genes in Listronotus oregonensis, advancing genetic insights into a key agricultural pest. Compared with related species, L. oregonensis exhibits reduced chemoreceptor gene families but expanded detoxification gene clusters, reflecting its narrow host range and adaptability.
Dave T. Ste‐Croix, Annie‐Ève Gagnon, Benjamin Mimee   +2 more
wiley   +1 more source

Microbiome‐urothelium crosstalk in bladder cancer: From dysbiosis to clinical translation

iMetaOmics, Volume 3, Issue 1, March 2026.
This review elucidates the critical crosstalk between the urobiome and bladder cancer (BCa), mapping the landscape from ecological dysbiosis to clinical translation. We synthesize emerging evidence on microbial signatures that distinguish BCa patients, exploring key carcinogenic mechanisms including chronic inflammation, genotoxicity, and the gut ...
Haoxiang Xu, Zhibiao Li, Lin Yang, Jun Zheng, Weijia Li, Rulin Liao, Wenxue Huang, Boyuan Sun, Zhuohang Li, Cunzhen Ma, Xunguo Yang, Zongwei Wang, Jie Zhao, Bisheng Cheng, Peng Wu   +14 more
wiley   +1 more source

A new functional site W115 in CdtA is critical for Aggregatibacter actinomycetemcomitans cytolethal distending toxin. [PDF]

PLoS ONE, 2013
Aggregatibacter actinomycetemcomitans, a specific pathogen of localized aggressive periodontitis, produces a cytolethal distending toxin (CDT) that arrests eukaryotic cells irreversibly in G0/G1 or G2/M phase of the cell cycle.
Lu Li, Cheng Ding, Jun-lan Duan, Mi-fang Yang, Ying Sun, Xiao-qian Wang, Yan Xu   +6 more
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Exploring the Key Role of Nanotechnology on Intratumoral Microbiome Modulation for Cancer Immunotherapy

MedComm – Biomaterials and Applications, Volume 5, Issue 1, March 2026.
The review provides a comprehensive analysis of microbiome‐mediated oncogenic mechanisms in various cancers, emphasizing the unique therapeutic strategies facilitated by nanotechnology. It aims to fill this gap by systematically reviewing nanotechnology‐driven strategies for microbiome elimination, with a focus on their ability to improve the cold TME ...
Yumei Gan, Yan Zhang, Xia Dong, Feng Lv
wiley   +1 more source

Rapamycin Exerts Its Geroprotective Effects in the Ageing Human Immune System by Enhancing Resilience Against DNA Damage

Aging Cell, Volume 25, Issue 2, February 2026.
Using in vitro DNA damage assays in human T cells, ex vivo profiling of aged immune subsets and a small placebo‐controlled in vivo study, authors show that low‐dose rapamycin, a potent life‐extending mTOR inhibitor, enhances resilience against DNA damage in the human immune system.
Loren Kell, Eleanor J. Jones, Nima Gharahdaghi, Daniel J. Wilkinson, Kenneth Smith, Philip J. Atherton, Anna K. Simon, Lynne S. Cox, Ghada Alsaleh   +8 more
wiley   +1 more source

Characterization of the cytolethal distending toxin (typhoid toxin) in non-typhoidal Salmonella serovars

Gut Pathogens, 2015
For many putative Salmonella enterica subsp. enterica virulence genes, functional characterization across serovars has been limited. Cytolethal distending toxin B (CdtB) is an incompletely characterized virulence factor that is found not only in Salmonella enterica subsp.
Rodriguez-Rivera, Lorraine D, Bowen, Barbara M, den Bakker, Henk C, Duhamel, Gerald E, Wiedmann, Martin   +4 more
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