Results 61 to 70 of about 128,137 (125)

Bacterial Toxin Modulation of the Eukaryotic Cell Cycle: Are all Cytolethal Distending Toxins Created Equally?

Frontiers in Cellular and Infection Microbiology, 2012
The cytolethal distending toxins (CDTs) comprise a family of intracellular-acting bacterial protein toxins whose actions upon eukaryotic cells result in several consequences, the most characteristic of which is the induction of G2/M cell cycle arrest ...
Amandeep eGargi, Michael eReno, Steven R Blanke   +2 more
doaj   +1 more source

A plasmid-mediated type III secretion system associated with invasiveness and diarrheagenicity of Providencia rustigianii

mBio
We have recently described a clinical isolate of Providencia rustigianii strain JH-1 carrying the genes for cytolethal distending toxin (CDT) in a conjugative plasmid.
Jayedul Hassan, Atsushi Hinenoya, Noritoshi Hatanaka, Sharda Prasad Awasthi, Goutham Belagula Manjunath, Nahid Rahman, Jyoji Yamate, Shota Nakamura, Daisuke Motooka, Akira Nagita, Shah M. Faruque, Shinji Yamasaki   +11 more
doaj   +1 more source

Internalization of the Active Subunit of the Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin Is Dependent upon Cellugyrin (Synaptogyrin 2), a Host Cell Non-Neuronal Paralog of the Synaptic Vesicle Protein, Synaptogyrin 1

Frontiers in Cellular and Infection Microbiology, 2017
The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is a heterotrimeric AB2 toxin capable of inducing lymphocytes, and other cell types, to undergo cell cycle arrest and apoptosis.
Kathleen Boesze-Battaglia, Lisa P. Walker, Anuradha Dhingra, Konstantin Kandror, Hsin-Yao Tang, Bruce J. Shenker   +5 more
doaj   +1 more source

The Cytolethal Distending Toxin Subunit CdtB of Helicobacter hepaticus Promotes Senescence and Endoreplication in Xenograft Mouse Models of Hepatic and Intestinal Cell Lines

Frontiers in Cellular and Infection Microbiology, 2017
Cytolethal distending toxins (CDTs) are common among pathogenic bacteria of the human and animal microbiota. CDTs exert cytopathic effets, via their active CdtB subunit.
Christelle Péré-Védrenne, Christelle Péré-Védrenne, Martina Prochazkova-Carlotti, Martina Prochazkova-Carlotti, Benoit Rousseau, Wencan He, Wencan He, Lucie Chambonnier, Lucie Chambonnier, Elodie Sifré, Elodie Sifré, Alice Buissonnière, Alice Buissonnière, Pierre Dubus, Pierre Dubus, Pierre Dubus, Francis Mégraud, Francis Mégraud, Christine Varon, Christine Varon, Armelle Ménard, Armelle Ménard   +21 more
doaj   +1 more source

Genotoxicity of Cytolethal Distending Toxin (CDT) on isogenic human colorectal cell lines: potential promoting effects for colorectal carcinogenesis

Frontiers in Cellular and Infection Microbiology, 2016
The composition of the human microbiota influences tumorigenesis, notably in colorectal cancer (CRC). Pathogenic Escherichia coli possesses a variety of virulent factors, among them the Cytolethal Distending Toxin (CDT).
Vanessa eGraillot, Inge eDormoy, Jacques eDupuy, Jerry eShay, Laurence eHuc, Gladys eMirey, Julien eVignard   +6 more
doaj   +1 more source

Development of two alternative models of campylobacter jejuni infection that more closely mimic the in vivo environment [PDF]

Campylobacter JeJum IS the leading cause of foodborne gastroenteritis worldwide, yet despite the organism's prevalence, relatively little is known about the mechanisms of pathogenesis.
Mills, Dominic Christopher
core   +1 more source

: involvement of the cytolethal distending toxin

, 2004
The cytolethal distending toxin (Cdt) is produced by several Gram-negative bacterial species and causes growth arrest and morphological alterations in mammalian cells.
G. N. BELIBASAKIS, C. CHEN, Johansson, Anders,, Mattsson, Anna,, A. MATTSSON, Belibasakis, Georgios N,, Wang, Ying, Chen, Casey, Y. WANG, A. JOHANSSON   +9 more
core   +1 more source

Perinuclear Localization of Internalized Outer Membrane Vesicles Carrying Active Cytolethal Distending Toxin from Aggregatibacter actinomycetemcomitans

, 2012
Aggregatibacter actinomycetemcomitans is implicated in aggressive forms of periodontitis. Similarly to several other Gram-negative species, this organism produces and excretes a cytolethal distending toxin (CDT), a genotoxin associated with ...
Asikainen, Sirkka,, Thay, Bernard,, Oscarsson, Jan,, Pramod Kumar Rompikuntal, Rompikuntal, Pramod Kumar,, Bernard Thay, Khan, Muhammad Khanzeb,, Anna-Maija Penttinen, Wai, Sun Nyunt,, Jan Oscarsson, Muhammad Khanzeb Khan, Sirkka Asikainen, Alanko, Jonna,, Sun Nyunt Wai, Jonna Alanko, Penttinen, Anna-Maija,   +15 more
core   +1 more source

Structural and functional analysis of Helicobacter hepaticus cytolethal distending toxin

, 2009
Helicobacter hepaticus (H. hepaticus) the prototype for enterohepatic Helicobacter species (EHS), colonizes the lower intestinal and hepatobiliary tract of mice and causes typhlocolitis, hepatitis, and hepatocellular carcinoma in susceptible mouse ...
Malimbada Liyanage, Namal Prasanna
core  

Upregulation of occludin by cytolethal distending toxin facilitates Glaesserella parasuis adhesion to respiratory tract cells. [PDF]

Infect Immun, 2023
Yang Z, Zhang Y, Du S, Zhao Q, Huang X, Wu R, Yan Q, Han X, Cao S, Chang Y-F, Wen Y.   +10 more
europepmc   +1 more source