Results 81 to 90 of about 2,764 (156)

A. actinomycetemcomitans Cytolethal Distending Toxin [PDF]

The Journal of Immunology, 2004
Monica, Thelestam, Teresa, Frisan
openaire   +2 more sources

Genotoxicity of Cytolethal Distending Toxin (CDT) on isogenic human colorectal cell lines: potential promoting effects for colorectal carcinogenesis

Frontiers in Cellular and Infection Microbiology, 2016
The composition of the human microbiota influences tumorigenesis, notably in colorectal cancer (CRC). Pathogenic Escherichia coli possesses a variety of virulent factors, among them the Cytolethal Distending Toxin (CDT).
Vanessa eGraillot, Inge eDormoy, Jacques eDupuy, Jerry eShay, Laurence eHuc, Gladys eMirey, Julien eVignard   +6 more
doaj   +1 more source

Distinct Roles for CdtA and CdtC during Intoxication by Cytolethal Distending Toxins

PLOS ONE, 2015
Cytolethal distending toxins (CDTs) are heterotrimeric protein exotoxins produced by a diverse array of Gram-negative pathogens. The enzymatic subunit, CdtB, possesses DNase and phosphatidylinositol 3-4-5 trisphosphate phosphatase activities that induce host cell cycle arrest, cellular distension and apoptosis.
Shandee D Dixon, Melanie M Huynh, Batcha Tamilselvam, Lindsey M Spiegelman, Sophia B Son, Aria Eshraghi, Steven R Blanke, Kenneth A Bradley   +7 more
openaire   +4 more sources

Cytolethal distending toxins and activation of DNA damage-dependent checkpoint responses

International Journal of Medical Microbiology, 2001
Cytolethal distending toxins (CDTs) are unique among bacterial protein toxins in their ability to cause DNA damage, due to their functional similarity to the mammalian deoxyribonuclease I (DNase I). The cellular response to CDT intoxication is characterised by activation of DNA damage-induced checkpoint responses, and the final outcome is cell type ...
Teresa, Frisan, Ximena, Cortes-Bratti, Monica, Thelestam   +2 more
openaire   +2 more sources

Upregulation of occludin by cytolethal distending toxin facilitates Glaesserella parasuis adhesion to respiratory tract cells. [PDF]

Infect Immun, 2023
Yang Z, Zhang Y, Du S, Zhao Q, Huang X, Wu R, Yan Q, Han X, Cao S, Chang Y-F, Wen Y.   +10 more
europepmc   +1 more source

LRRC8A promotes Glaesserella parasuis cytolethal distending toxin-induced p53-dependent apoptosis in NPTr cells. [PDF]

Virulence, 2023
Mao W, Wang Z, Wen S, Lin Y, Gu J, Sun J, Wang H, Cao Q, Xu Y, Xu X, Cai X.   +10 more
europepmc   +1 more source

Host-associated variability of the cdtABC operon, coding for the cytolethal distending toxin, in Campylobacter jejuni. [PDF]

Zoonoses Public Health, 2022
Guirado P, Iglesias-Torrens Y, Miró E, Navarro F, Attolini CS, Balsalobre C, Madrid C.   +6 more
europepmc   +1 more source

Presence of Functionally Active Cytolethal Distending Toxin Genes on a Conjugative Plasmid in a Clinical Isolate of Providencia rustigianii. [PDF]

Infect Immun, 2023
Hassan J, Awasthi SP, Hatanaka N, Hoang PH, Nagita A, Hinenoya A, Faruque SM, Yamasaki S.   +7 more
europepmc   +1 more source

Campylobacter jejuni infection impacts host-derived miRNAs targeting bacterial and host genes

Microbiology Spectrum
The intestinal microbiota has been shown to influence host-derived microRNAs (miRNAs), small regulatory RNAs involved in host-pathogen interactions. However, the specific role of individual bacterial species in modulating host extracellular vesicles (EV)-
Siddhi Chitre, Raad Z. Gharaibeh, Rachel C. Newsome, Jinmai Jiang, Andrew Brock, Thomas D. Schmittgen, Christian Jobin   +6 more
doaj   +1 more source

Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin-Induces Cell Cycle Arrest in a Glycogen Synthase Kinase (GSK)-3-Dependent Manner in Oral Keratinocytes. [PDF]

Int J Mol Sci, 2022
Shenker BJ, Walker LP, Zekavat A, Korostoff J, Boesze-Battaglia K.   +4 more
europepmc   +1 more source