Results 91 to 100 of about 3,428 (189)

Bacterial Toxin Exploits Host Membrane Phospholipid as a Receptor for Binding, Entry, and Cytopathogenicity

Molecular Microbiology, Volume 125, Issue 2, Page 145-158, February 2026.
Mycoplasma pneumoniae pathogenesis relies on its CARDS toxin, which initiates cell binding and subsequent uptake by exploiting sphingomyelin, a key phospholipid found in the host plasma membrane. Maximal cellular entry and full cytotoxic effects are achieved through a synergistic mechanism that involves interaction with the protein coreceptor annexin ...
Alejandra M. Kirkpatrick, Thirumalai R. Kannan   +1 more
wiley   +1 more source

Cytolethal distending toxin (CDT)-negative Campylobacter jejuni strains and anti-CDT neutralising antibodies induced during human infection but not chicken colonisation

, 2005
The cytolethal distending toxin (CDT) of Campylobacter jejuni was detectable, using an in vitro assay, in most but not all of 24 strains tested. The reason for the absence of toxin activity in these naturally occurring CDT-negative C.
Ridley, A, Wassenaar, TM, Ahmed, IH, Cawthraw, SA, AbuOun, M, Manning, G, Newell, DG   +6 more
core  

Haemophilus parasuis cytolethal distending toxin induces cell cycle arrest and p53-dependent apoptosis.

PLoS ONE, 2017
Haemophilus parasuis is the causative agent of Glasser's disease in pigs. Cytolethal distending toxin (CDT) is an important virulence factor of H. parasuis.
Gang Li, Hui Niu, Yanhe Zhang, Yanling Li, Fang Xie, Paul R Langford, Siguo Liu, Chunlai Wang   +7 more
doaj   +1 more source

Harnessing Next‐Generation 3D Cancer Models to Elucidate Tumor‐Microbiome Crosstalk

Advanced Healthcare Materials, Volume 15, Issue 1, 9 January 2026.
Centralizes the microbiome within 3D tumor‐microbiome model platforms, including spheroids, organoids, 3D‐bioprinted constructs, and microfluidic chips, each enabling structured host‐tumor‐microbe studies. These systems support bacterial colonization, facilitating investigation of microbial impacts on tumor growth, immunity, and therapy. The microbiome
Marina Green Buzhor, Giuseppe Longobardi, Or Kandli, Anne Krinsky, Opal Avramoff, Anshika Katyal, Koren Salomon, Adan Miari, Dana Venkert, Tania T. Barnatan, América García Alvarado, Shahar Greenberg, Ronit Satchi‐Fainaro   +12 more
wiley   +1 more source

A Narrative Review on Unravelling Bacterial‐Mediated Carcinogenesis and Possible Alternative Treatment Strategies

BioMed Research International, Volume 2026, Issue 1, 2026.
The potential roles of chemical, physical, and viral factors in cancer development are well documented. Similarly, bacterial carcinogenesis has been reported previously, though not extensively. Therefore, we aimed to provide comprehensive, mechanistic evidence on the pathogenesis of bacteria‐induced carcinogenesis and possible treatments to halt cancer
Md Sohel, Suraiya Aktar, Sanzida Khatun, Sherif Hamidu, Nishat Ulfat Nity, Sandeep Kumar, Md Sakhawat Hossain, Md. Rifat Sarker, Snygdha Rani Das, Badhan Rani Dey, Ali Mohamod Wasaf Hasan, Khairul Islam, Farhadul Islam, Abdullah Al Mamun, Baisakhi Banerjee   +14 more
wiley   +1 more source

Characterization of the cytolethal distending toxin (typhoid toxin) in non-typhoidal Salmonella serovars

Gut Pathogens, 2015
For many putative Salmonella enterica subsp. enterica virulence genes, functional characterization across serovars has been limited. Cytolethal distending toxin B (CdtB) is an incompletely characterized virulence factor that is found not only in Salmonella enterica subsp.
Rodriguez-Rivera, Lorraine D, Bowen, Barbara M, den Bakker, Henk C, Duhamel, Gerald E, Wiedmann, Martin   +4 more
openaire   +2 more sources

Characterization and serotype distribution of Aggregatibacter actinomycetemcomitans detected in a population of periodontitis patients in Spain.

, 2009
Objective: To investigate the serotype distribution of Aggregatibacter actinomycetemcomitans (A. a.) and the polymorphism of the genes that codify the leukotoxin (ltx) and the operon of the cytolethal distending toxin (cdt) in periodontitis patients in ...
Blasi, Andrea
core  

Analysis of Virulence Genes and Antibiotic‐Resistant Profiles of Campylobacter in Huzhou, China

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2026, Issue 1, 2026.
Background Campylobacter is the leading bacterial cause of diarrheal illnesses worldwide. Campylobacter jejuni and Campylobacter coli are the main pathogens of Campylobacter infections. Drug‐resistant Campylobacter has been classified as a serious antibiotic resistance threat. Methods From 2021 to 2022, 68 Campylobacter were isolated from fecal samples
Xiaofang Wu, Fenfen Dong, Zhonghao Lu, Lei Ji, Liping Chen, Satabdi Datta Choudhury   +5 more
wiley   +1 more source

The Draft Genome Sequence of the Yersinia entomophaga Entomopathogenic Type Strain MH96T

Toxins, 2016
Here we report the draft genome of Yersinia entomophaga type strain MH96T. The genome shows 93.8% nucleotide sequence identity to that of Yersinia nurmii type strain APN3a-cT, and comprises a single chromosome of approximately 4,275,531 bp.
Mark R. H. Hurst, Amy Beattie, Eric Altermann, Roger M. Moraga, Lincoln A. Harper, Joanne Calder, Aurelie Laugraud   +6 more
doaj   +1 more source

: involvement of the cytolethal distending toxin

, 2004
The cytolethal distending toxin (Cdt) is produced by several Gram-negative bacterial species and causes growth arrest and morphological alterations in mammalian cells.
G. N. BELIBASAKIS, C. CHEN, Johansson, Anders,, Mattsson, Anna,, A. MATTSSON, Belibasakis, Georgios N,, Wang, Ying, Chen, Casey, Y. WANG, A. JOHANSSON   +9 more
core   +1 more source