Results 111 to 120 of about 3,428 (189)

Cholesterol-Rich Membrane Microdomains Mediate Cell Cycle Arrest Induced by Actinobacillus Actinomycetemcomitans Cytolethal-Distending Toxin

, 2006
We have previously shown that Actinobacillus actinomycetemcomitans cytolethal-distending toxin (Cdt) is a potent immunosuppressive agent that induces G2/M arrest in human lymphocytes.
Zekavat, Ali, Shenker, Bruce, Besack, Dave, Shenker, Bruce J., Jordan-Sciutto, Kelly, McKay, Terry, Otis, Linda, Boesze-Battaglia, Kathleen   +7 more
core   +2 more sources

Cellular internalization of cytolethal distending toxin: a new end to a known pathway

, 2005
The cytolethal distending toxins (CDTs) are unique in their ability to induce DNA damage, activate checkpoint responses and cause cell cycle arrest or apoptosis in intoxicated cells.
Randall K. Holmes, Frisan, Teresa, Thelestam, Monica, Bo Stenerlöw, Stenerlöw, Bo,, Teter, Ken, Ploegh, Hidde L., Lilley, Brendan N., Sandvig, Kirsten, Guerra, Lina, Lina Guerra, Hidde L. Ploegh, Kirsten Sandvig, Monica Thelestam, Brendan N. Lilley, Teresa Frisan, Ken Teter, Holmes, Randall K.   +17 more
core   +2 more sources

Bacteriophage-Encoding Cytolethal Distending Toxin Type V Gene Induced from Nonclinical Escherichia coli Isolates

, 2011
Cytolethal distending toxin (Cdt) is produced by a variety of pathogenic bacteria, including pathogenic serotypes of Shiga toxin-producing Escherichia coli (STEC). The Cdt family comprises five variants (Cdt-I to Cdt-V) encoded by
Anna Allué-Guardia, Cristina García-Aljaro, Maite Muniesa   +2 more
core   +1 more source

Lipooligosaccharide and Cytolethal distending toxin of Haemophilus ducreyi and antibody responses

, 2010
The Gram-negative bacterium Haemophilus ducreyi causes chancroid, a sexually transmitted infection characterized by persistent ulcers on genitals. The disease is prevalent in developing countries and facilitates transmission and acquisition of HIV ...
Lundqvist, Annika
core  

Toxic activity of the CdtB component of Haemophilus ducreyi cytolethal distending toxin expressed from an adenovirus 5 vector

, 2010
The Haemophilus ducreyi cytolethal distending toxin (HdCDT) catalytic subunit CdtB has DNase-like activity and mediates DNA damage after its delivery into target cells. We constructed a replication-deficient adenovirus type 5 (Ad5) vector expressing CdtB
Lindholm, Leif,, Wising, Catharina,, Magnusson, Maria K,, Lagergård, Teresa,, Ahlman, Karin,   +4 more
core   +1 more source

Intoxication of mammalian cells by the cytolethal distending toxin of Haemophilus ducreyi : a novel mechanism of action

, 2001
The cytolethal distending toxins (CDTs) are a newly described family of bacterial protein toxins with a novel mechanism of action: DNA damage. Haemophilus ducreyi produces a cytotoxin that belongs to this family.
Ximena Cortes Bratti (19525963)
core  

Draft Genome Sequence of an Escherichia coli O157:H43 Strain Isolated from Cattle

, 2013
Here we report the draft genome sequence of an Escherichia coli O157:H43 strain, designated T22, with an atypical virulence gene profile and isolated from healthy cattle.
Maróti, Gergely, Szűcs, Attila, Sváb, Domonkos, Horváth, Balázs, Tóth, István   +4 more
core   +1 more source

Campylobacter jejuni infection impacts host-derived miRNAs targeting bacterial and host genes

Microbiology Spectrum
The intestinal microbiota has been shown to influence host-derived microRNAs (miRNAs), small regulatory RNAs involved in host-pathogen interactions. However, the specific role of individual bacterial species in modulating host extracellular vesicles (EV)-
Siddhi Chitre, Raad Z. Gharaibeh, Rachel C. Newsome, Jinmai Jiang, Andrew Brock, Thomas D. Schmittgen, Christian Jobin   +6 more
doaj   +1 more source

Study of the cytolethal distending toxin (CDT)-activated cell cycle checkpoint Involvement of the CHK2 kinase

, 2001
The bacterial cytolethal distending toxin (CDT) triggers a G2/M cell cycle arrest in eukaryotic cells by inhibiting the CDC25C phosphatase-dependent CDK1 dephosphorylation and activation.
Darbon, Jean-Marie, Guillou, E., Emmanuelle Guillou, Véronique Baldin, Guillou, Emmanuelle, Bernard Ducommun, Ducommun, Bernard, Frédéric Alby, Raoul Mazars, Darbon, J.M., Mazars, R., Mazars, Raoul, Ducommun, B., Baldin, V., Jean de Rycke, Baldin, Véronique, de Rycke, Jean, Jean-Marie Darbon, Alby, F., Alby, Frédéric   +19 more
core   +1 more source

RAGE participates in the intracellular transport of Campylobacter jejuni cytolethal distending toxin

Journal of Microbiology, Immunology and Infection
Cytolethal distending toxin (CDT) belongs to the genotoxin family and is closely related to Campylobacter jejuni-associated gastroenteritis. We recently reported that CDT triggers the danger-associated molecular pattern (DAMP) signaling to exert deleterious effects on host cells.
Yu-Fang Chang, Yi-Ping Huang, Chia-Huei Chou, Mao-Wang Ho, Hwai-Jeng Lin, Chun-Ya Chen, Hui-Yu Wu, Yi-Ru Lai, Yuan-Haw Lee, Cheng-Hsun Chiu, Chih-Ho Lai   +10 more
openaire   +2 more sources