Results 71 to 80 of about 2,764 (156)

Production of cytolethal distending toxin and other virulence characteristics of Escherichia coli strains of serogroup O86

Memorias do Instituto Oswaldo Cruz, 2001
Genetic and phenotypic virulence markers of different categories of diarrhoeagenic Escherichia coli were investigated in 106 strains of enteropathogenic E. coli (EPEC) serogroup O86. The most frequent serotype found was O86:H34 (86%).
Ângela Cristina Rodrigues Ghilardi, Tânia Aparecida Tardelli Gomes, Luiz Rachid Trabulsi   +2 more
doaj   +1 more source

Bacterial Toxin Exploits Host Membrane Phospholipid as a Receptor for Binding, Entry, and Cytopathogenicity

Molecular Microbiology, Volume 125, Issue 2, Page 145-158, February 2026.
Mycoplasma pneumoniae pathogenesis relies on its CARDS toxin, which initiates cell binding and subsequent uptake by exploiting sphingomyelin, a key phospholipid found in the host plasma membrane. Maximal cellular entry and full cytotoxic effects are achieved through a synergistic mechanism that involves interaction with the protein coreceptor annexin ...
Alejandra M. Kirkpatrick, Thirumalai R. Kannan   +1 more
wiley   +1 more source

Haemophilus parasuis cytolethal distending toxin induces cell cycle arrest and p53-dependent apoptosis.

PLoS ONE, 2017
Haemophilus parasuis is the causative agent of Glasser's disease in pigs. Cytolethal distending toxin (CDT) is an important virulence factor of H. parasuis.
Gang Li, Hui Niu, Yanhe Zhang, Yanling Li, Fang Xie, Paul R Langford, Siguo Liu, Chunlai Wang   +7 more
doaj   +1 more source

Harnessing Next‐Generation 3D Cancer Models to Elucidate Tumor‐Microbiome Crosstalk

Advanced Healthcare Materials, Volume 15, Issue 1, 9 January 2026.
Centralizes the microbiome within 3D tumor‐microbiome model platforms, including spheroids, organoids, 3D‐bioprinted constructs, and microfluidic chips, each enabling structured host‐tumor‐microbe studies. These systems support bacterial colonization, facilitating investigation of microbial impacts on tumor growth, immunity, and therapy. The microbiome
Marina Green Buzhor, Giuseppe Longobardi, Or Kandli, Anne Krinsky, Opal Avramoff, Anshika Katyal, Koren Salomon, Adan Miari, Dana Venkert, Tania T. Barnatan, América García Alvarado, Shahar Greenberg, Ronit Satchi‐Fainaro   +12 more
wiley   +1 more source

A Narrative Review on Unravelling Bacterial‐Mediated Carcinogenesis and Possible Alternative Treatment Strategies

BioMed Research International, Volume 2026, Issue 1, 2026.
The potential roles of chemical, physical, and viral factors in cancer development are well documented. Similarly, bacterial carcinogenesis has been reported previously, though not extensively. Therefore, we aimed to provide comprehensive, mechanistic evidence on the pathogenesis of bacteria‐induced carcinogenesis and possible treatments to halt cancer
Md Sohel, Suraiya Aktar, Sanzida Khatun, Sherif Hamidu, Nishat Ulfat Nity, Sandeep Kumar, Md Sakhawat Hossain, Md. Rifat Sarker, Snygdha Rani Das, Badhan Rani Dey, Ali Mohamod Wasaf Hasan, Khairul Islam, Farhadul Islam, Abdullah Al Mamun, Baisakhi Banerjee   +14 more
wiley   +1 more source

The Draft Genome Sequence of the Yersinia entomophaga Entomopathogenic Type Strain MH96T

Toxins, 2016
Here we report the draft genome of Yersinia entomophaga type strain MH96T. The genome shows 93.8% nucleotide sequence identity to that of Yersinia nurmii type strain APN3a-cT, and comprises a single chromosome of approximately 4,275,531 bp.
Mark R. H. Hurst, Amy Beattie, Eric Altermann, Roger M. Moraga, Lincoln A. Harper, Joanne Calder, Aurelie Laugraud   +6 more
doaj   +1 more source

Cytolethal Distending Toxin and Its Implication in Periodontal Diseases

Journal of Oral Biosciences, 2005
Abstract Cytolethal distending toxin (Cdt) is a new bacterial toxin that hijacks the control systems of target cells. Cdt is composed of three subunits, CdtA, CdtB and CdtC, all of which form a tripartite complex, and are produced by several bacterial pathogens including Actinobacillus actinomycetemcomitans .
Ohara, Masaru, Sugai, Motoyuki
openaire   +1 more source

A plasmid-mediated type III secretion system associated with invasiveness and diarrheagenicity of Providencia rustigianii

mBio
We have recently described a clinical isolate of Providencia rustigianii strain JH-1 carrying the genes for cytolethal distending toxin (CDT) in a conjugative plasmid.
Jayedul Hassan, Atsushi Hinenoya, Noritoshi Hatanaka, Sharda Prasad Awasthi, Goutham Belagula Manjunath, Nahid Rahman, Jyoji Yamate, Shota Nakamura, Daisuke Motooka, Akira Nagita, Shah M. Faruque, Shinji Yamasaki   +11 more
doaj   +1 more source

Internalization of the Active Subunit of the Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin Is Dependent upon Cellugyrin (Synaptogyrin 2), a Host Cell Non-Neuronal Paralog of the Synaptic Vesicle Protein, Synaptogyrin 1

Frontiers in Cellular and Infection Microbiology, 2017
The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is a heterotrimeric AB2 toxin capable of inducing lymphocytes, and other cell types, to undergo cell cycle arrest and apoptosis.
Kathleen Boesze-Battaglia, Lisa P. Walker, Anuradha Dhingra, Konstantin Kandror, Hsin-Yao Tang, Bruce J. Shenker   +5 more
doaj   +1 more source

The Cytolethal Distending Toxin Subunit CdtB of Helicobacter hepaticus Promotes Senescence and Endoreplication in Xenograft Mouse Models of Hepatic and Intestinal Cell Lines

Frontiers in Cellular and Infection Microbiology, 2017
Cytolethal distending toxins (CDTs) are common among pathogenic bacteria of the human and animal microbiota. CDTs exert cytopathic effets, via their active CdtB subunit.
Christelle Péré-Védrenne, Christelle Péré-Védrenne, Martina Prochazkova-Carlotti, Martina Prochazkova-Carlotti, Benoit Rousseau, Wencan He, Wencan He, Lucie Chambonnier, Lucie Chambonnier, Elodie Sifré, Elodie Sifré, Alice Buissonnière, Alice Buissonnière, Pierre Dubus, Pierre Dubus, Pierre Dubus, Francis Mégraud, Francis Mégraud, Christine Varon, Christine Varon, Armelle Ménard, Armelle Ménard   +21 more
doaj   +1 more source