Results 51 to 60 of about 3,428 (189)

Trans-Cinnamaldehyde, Carvacrol, and Eugenol Reduce Campylobacter jejuni Colonization Factors and Expression of Virulence Genes in Vitro

Frontiers in Microbiology, 2017
Campylobacter jejuni is a major foodborne pathogen that causes severe gastroenteritis in humans characterized by fever, diarrhea, and abdominal cramps. In the human gut, Campylobacter adheres and invades the intestinal epithelium followed by cytolethal ...
Dan J. Donoghue, Abhinav Upadhyay, Komala Arsi, Basanta R. Wagle, Indu Upadhyaya, Sandip Shrestha, Ann M. Donoghue   +6 more
doaj   +1 more source

Mechanisms of Assembly and Cellular Interactions for the Bacterial Genotoxin CDT. [PDF]

PLoS Pathogens, 2005
Many bacterial pathogens that cause different illnesses employ the cytolethal distending toxin (CDT) to induce host cell DNA damage, leading to cell cycle arrest or apoptosis. CDT is a tripartite holotoxin that consists of a DNase I family nuclease (CdtB)
Dragana Nesic, C Erec Stebbins
doaj   +2 more sources

Reconstitution and Purification of Cytolethal Distending Toxin of Actinobacillus actinomycetemcomitans [PDF]

Microbiology and Immunology, 2001
AbstractCytolethal distending toxin (CDT) has been found in various pathogenic bacterial species and causes a cell distending and a G2 arrest against eukaryotic cells. All the cdtABC genes, which encode CDT, are known to be required for the CDT activities although the CDT holotoxin structure has not been elucidated.
K, Saiki, K, Konishi, T, Gomi, T, Nishihara, M, Yoshikawa   +4 more
openaire   +2 more sources

Haemophilus parasuis encodes two functional cytolethal distending toxins: CdtC contains an atypical cholesterol recognition/interaction region. [PDF]

PLoS ONE, 2012
Haemophilus parasuis is the causative agent of Glässer's disease of pigs, a disease associated with fibrinous polyserositis, polyarthritis and meningitis. We report here H.
Mingguang Zhou, Qiang Zhang, Jianping Zhao, Meilin Jin   +3 more
doaj   +1 more source

Introns in the Cytolethal Distending Toxin Gene ofActinobacillus actinomycetemcomitans [PDF]

Journal of Bacteriology, 2005
ABSTRACTIn eukaryotic cells, genes are interrupted by intervening sequences called introns. Introns are transcribed as part of a precursor RNA that is subsequently removed by splicing, giving rise to mature mRNA. However, introns are rarely found in bacteria.Actinobacillus actinomycetemcomitansis a periodontal pathogen implicated in aggressive forms of
Kai, S.T., Keang, P.S., Ong, G.
openaire   +2 more sources

Diagnostic potential of various laboratory tests for irritable bowel syndrome (IBS): a systematic review

Journal of the Pakistan Medical Association
Objective: To identify possible tests along with their accuracies that may be used to diagnose irritable bowel syndrome. Method: The systematic review comprised literature search on Cochrane Library, PubMed, Science Direct and Elsevier databases for ...
Misha Mansoor, Muhammad Hamza Shafiq, Mahnoor Imran, Fiza Mushtaq, Sana Iftikhar, Fuad Shafiq   +5 more
doaj   +1 more source

Sequence Variability of P2-Like Prophage Genomes Carrying the Cytolethal Distending Toxin V Operon in Escherichia coli O157

, 2013
Cytolethal distending toxins (CDT) are potent cytotoxins of several Gram-negative pathogenic bacteria, including Escherichia coli, in which five types (CDT-I to CDT-V) have been identified so far.
Dobrindt, Ulrich, Maróti, Gergely, Sváb, Domonkos, Horváth, Balázs, Tóth, István   +4 more
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In vivovirulence properties of bacterial cytolethal-distending toxin [PDF]

Cellular Microbiology, 2008
Multiple pathogenic Gram-negative bacteria produce cytolethal-distending toxins (CDTs). CDT is typically composed of three subunits: the catalytic subunit CdtB has DNase I-like activity, whereas CdtA and CdtC are binding proteins for delivering CdtB into target cells.
Zhongming, Ge, David B, Schauer, James G, Fox   +2 more
openaire   +2 more sources

Prevalence of virulence genes and cytolethal distending toxin production in Campylobacter jejuni isolates from diarrheal patients in Bangladesh [PDF]

, 2008
From 300 stool samples, 58 Campylobacter strains were isolated by standard microbiological and biochemical methods. Of these, 40 strains were identified as Campylobacter jejuni and 5 as Campylobacter coli.
Sack, David A., Nur-E-Kamal, A, Talukder, K.A. (Kaisar), D. A. Sack, Dutta, Dilip K., G. B. Nair, Azmi, Ishrat J., I. J. Azmi, Hossain, S, Dutta, D.K. (Dilip), Azmi, IJ, S. Hossain, Dutta, DK, Hossain, S. (S.), Islam, Zhahirul, D. K. Dutta, Nur-E-Kamal, A. (Alam), H. P. Endtz, Talukder, KA, Nair, GB, Talukder, Kaisar A., Endtz, Hubert P., K. A. Talukder, M. Aslam, Islam, Z. (Zhahirul), Z. Islam, Nair, G.B. (Gopinath), Cravioto, A. (Alejandro), A. Nur-E-Kamal, Sack, DA, A. Cravioto, Endtz , Hubert P., Hossain, Sabir, Sack, D.A. (David), Nur-E-Kamal, Alam, Azmi, I.J. (Ishrat), Nair, Gopinath B., Islam, Z, Endtz, Hubert, Endtz, H.P. (Hubert), Aslam, Mohammad, Cravioto, Alejandro, Aslam, M. (Mohammad), Cravioto, A, Aslam, M, Nur-E-Kama, Alam   +45 more
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Cholesterol Depletion Reduces Entry of Campylobacter jejuni Cytolethal Distending Toxin and Attenuates Intoxication of Host Cells

, 2011
Campylobacter jejuni is a common cause of pediatric diarrhea worldwide. Cytolethal distending toxin, produced by Campylobacter jejuni, is a putative virulence factor that induces cell cycle arrest and apoptosis in eukaryotic cells.
Lai, C.K., 蘇鴻麟, Chang, Y.C., Wen-Ching Wang, Cheng-Kuo Lai, Chen, K.C., Yun-Chieh Chang, Jer-Tsong Hsieh, Yu-Ting Sing, Wang, W.C., Lin, Y.H., Lai, C.H., Chia-Der Lin, Sing, Y.T., Hong-Lin Su, Yu-Hsin Lin, Hsieh, J.T., Kai-Chuan Chen, Su, H.L., Chih-Ho Lai, Lin, C.D.   +20 more
core   +1 more source