Results 51 to 60 of about 2,764 (156)

Periodontitis and Rheumatoid Arthritis—Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
Periodontitis and rheumatoid arthritis are linked via the two‐hit model whereby early periodontal inflammation can lead to autoantibody production capable of interacting with inflamed synovial tissues. Subsequent systemic inflammation can exacerbate the periodontal inflammatory response and bacterial dysbiosis leading to further autoantibody production
Mark Bartold, Chia Wei Cheah, Rathna Devi Vaithilingam   +2 more
wiley   +1 more source

Characterisation of cytolethal distending toxin (CDT) mutants of Campylobacter jejuni [PDF]

Journal of Medical Microbiology, 2000
In order to assess the contribution of cytolethal distending toxin (CDT) to the toxigenicity and pathogenicity of Campylobacter jejuni, the C. jejuni 81-176 and C. jejuni NCTC 11168 CDTs were inactivated by insertional mutation of the cdtB toxin subunit. Cell-free sonicates from isogenic C.
D, Purdy, C M, Buswell, A E, Hodgson, K, McALPINE, I, Henderson, S A, Leach   +5 more
openaire   +2 more sources

Cytolethal Distending Toxin Enhances Radiosensitivity in Prostate Cancer Cells by Regulating Autophagy

Frontiers in Cellular and Infection Microbiology, 2017
Cytolethal distending toxin (CDT) produced by Campylobacter jejuni contains three subunits: CdtA, CdtB, and CdtC. Among these three toxin subunits, CdtB is the toxic moiety of CDT with DNase I activity, resulting in DNA double-strand breaks (DSB) and ...
Hwai-Jeng Lin, Hwai-Jeng Lin, Hsin-Ho Liu, Hsin-Ho Liu, Chia-Der Lin, Chia-Der Lin, Min-Chuan Kao, Yu-An Chen, Chuan Chiang-Ni, Chuan Chiang-Ni, Zhi-Pei Jiang, Mei-Zi Huang, Chun-Jung Lin, U-Ging Lo, Li-Chiung Lin, Li-Chiung Lin, Cheng-Kuo Lai, Ho Lin, Jer-Tsong Hsieh, Cheng-Hsun Chiu, Cheng-Hsun Chiu, Chih-Ho Lai, Chih-Ho Lai, Chih-Ho Lai, Chih-Ho Lai   +24 more
doaj   +1 more source

Clinical Management of Helicobacter Infection in Captive Baboons (Papio anubis and Papio hamadryas), and Isolation and Molecular Characterization of Three Novel Helicobacter Species

Journal of Medical Primatology, Volume 55, Issue 4, August 2026.
ABSTRACT Background Helicobacter spp. are gastric or enterohepatic bacteria that can be commensal, opportunistic, or pathogenic. Few studies have evaluated Helicobacter spp. in baboons. Methods Twenty‐seven captive baboons were surveyed for Helicobacter spp. by fecal PCR, and a subset evaluated by culture.
Isabel A. Jimenez, Courtney Lunger, Marcus J. Crim, Shannon L. Primm, Anthony Mannion, Nathan P. Crilly, Lydia M. Hopper, Lindsey G. Thurman, Linnette L. Vasquez, Cory Brayton, Yan Feng, James G. Fox, Zeli Shen, Jessica M. Izzi   +13 more
wiley   +1 more source

Outer membrane vesicle-mediated release of cytolethal distending toxin (CDT) from Campylobacter jejuni

BMC Microbiology, 2009
Background Background: Cytolethal distending toxin (CDT) is one of the well-characterized virulence factors of Campylobacter jejuni, but it is unknown how CDT becomes surface-exposed or is released from the bacterium to the surrounding environment ...
Uhlin Bernt, Mizunoe Yoshimitsu, Song Tianyan, Vaitkevicius Karolis, Rompikuntal Pramod, Lindmark Barbro, Guerry Patricia, Wai Sun   +7 more
doaj   +1 more source

Intratumoral Microbiota in Tumor: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 7, July 2026.
Intratumoral bacteria are emerging as active regulators of cancer evolution rather than bystanders. This review outlines how tumor‐resident microbes drive tumor initiation and growth by inducing genomic instability, epigenetic reprogramming, oncogenic signaling, and chronic inflammation, while promoting metastatic spread via invasion, angiogenesis ...
Jiawei Chen, Yupan Bai, Lu Shen, Jiacheng Ying, Jie Xu, Jiayin Tang, Yujie Bao   +6 more
wiley   +1 more source

Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?

Medicinal Research Reviews, Volume 46, Issue 4, Page 1111-1151, July 2026.
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca, Mariana Feijó, Cátia V. Vaz, Bruno J. Pereira, Sandra Laurentino, Ana Palmeira‐de‐Oliveira, Sílvia Socorro   +6 more
wiley   +1 more source

Bacterial Genotoxins: Merging the DNA Damage Response into Infection Biology

Biomolecules, 2015
Bacterial genotoxins are unique among bacterial toxins as their molecular target is DNA. The consequence of intoxication or infection is induction of DNA breaks that, if not properly repaired, results in irreversible cell cycle arrest (senescence) or ...
Francesca Grasso, Teresa Frisan
doaj   +1 more source

Hospital‐Associated Antimicrobial Resistant Bacteria on 95 Mobile Phones: An International Metagenomic “Phonome” Analysis

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
On average, phones harbored 3.62 of the top 10 killers and 2.49 ESKAPE organisms. In total, 667 VFGs (8621 Hits) and 262 ARGs (2475 Hits) were identified on 95 mobile phones. Mobile phones serve as a platform for horizontal gene transfer and AMR development.
Adrian Goldsworthy, Matthew Olsen, Nchafatso G. Obonyo, Peter Jones, Simon McKirdy, Abiola Senok, Rashed Alghafri, Rose Ghemrawi, Reem Almheiri, Oystein Tronstad, Jacky Y. Suen, John F. Fraser, Lotti Tajouri   +12 more
wiley   +1 more source

Typhoid Toxin of Salmonella enterica Induces ISG15 Responses Mediating Host Cell Survival and Counteracting Intracellular Infection

Molecular Microbiology, Volume 125, Issue 6, Page 475-492, June 2026.
Toxigenic Salmonella enterica exocytose the typhoid toxin during infection causing host cell DNA damage, which activates a Type‐1 Interferon‐like response characterised by interferon‐stimulated gene 15 (ISG15) expression. ISG15 was required for host cell survival during Interferon responses and suppressed intracellular growth of Salmonella. Thus, ISG15
Daniel S. Stark, Michelle King, Angela E. M. Ibler, Salma Srour, Francesca Brown, James Sheffield, Nadia Baseer, Ellen G. Vernon, Yifeng Zhang, Christopher Staples, Lilliana Radoshevich, Daniel Humphreys   +11 more
wiley   +1 more source