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Fusobacterium equinum possesses a leukotoxin gene and exhibits leukotoxin activity

Veterinary Microbiology, 2008
Fusobacterium equinum, a gram negative, rod-shaped and an obligate anaerobic bacterium is a newly described species. The organism is associated with necrotic infections of the respiratory tract in horses that include necrotizing pneumonia, pleuritis and paraoral infections. The species is closely related to F. necrophorum that causes liver abscesses in
Sambasivarao, Tadepalli   +4 more
openaire   +2 more sources

Leukotoxins of gram-negative bacteria

Veterinary Microbiology, 2002
Leukotoxins are a group of exotoxins that produce their primary toxic effects against leukocytes, especially polymorphonuclear cells (PMNs). Leukotoxins include a variety of chemicals ranging from 9,10-epoxy 12-octadecenoate, a fatty acid derivative secreted by leukocytes themselves, to proteins such as RTX (repeats in toxin).
Sanjeev Kumar, Narayanan   +3 more
openaire   +2 more sources

Pasteurella haemolytica leukotoxin: Physicochemical characteristics and susceptibility of leukotoxin to enzymatic treatment

American Journal of Veterinary Research, 1986
SUMMARY Sterile, concentrated culture supernatant from Pasteurella haemolytica (biotype A, serotype 1) strain 630 was subjected to physical, chemical, and immunologic treatments to determine their influence on leukotoxin (cytotoxin) activity contained in the supernatant.
Y F, Chang, H W, Renshaw, A B, Richards
openaire   +2 more sources

Isolation of Pasteurella haemolytica leukotoxin mutants

Infection and Immunity, 1995
Two mutants of Pasteurella haemolytica A1 that do not produce leukotoxin were isolated. Following mutagenesis, colonies were screened with antiserum by a filter assay for absence of the secreted leukotoxin. The two mutants both appeared to produce normal amounts of other antigens, as judged by reactivity with polyclonal serum from an animal with ...
M, Chidambaram   +5 more
openaire   +2 more sources

Leukotoxin operon and differential expressions of the leukotoxin gene in bovine Fusobacterium necrophorum subspecies

Anaerobe, 2008
Liver abscesses in cattle are associated primarily with Fusobacterium necrophorum, a gram negative, pleomorphic, and obligate anaerobe. In cattle, the organism is a normal inhabitant of the rumen and an opportunistic pathogen. There are two subspecies: subsp. necrophorum and subsp. funduliforme. Subspecies necrophorum is more frequently isolated, often
Sambasivarao, Tadepalli   +3 more
openaire   +2 more sources

LEUKOTOXIN PRODUCTION BY ACTINOBACILLUS ACTINOMYCETEMCOMITANS

Toxin Reviews, 2006
Actinobacillus actinomycetemcomitans is a gram-negative pathogen that causes human severe periodontitis. The most intensively studied virulence factor of this bacterium is a pore-forming cytotoxin termed leukotoxin. Production of leukotoxin varies considerably among A. actinomycetemcomitans strains.
Tetsuyoshi Inoue   +2 more
openaire   +1 more source

Hemolytic activity of the Pasteurella haemolytica leukotoxin

Infection and Immunity, 1995
A Pasteurella haemolytica mutant incapable of producing leukotoxin was created by allelic replacement. Concentrated culture supernatants from wild-type P. haemolytica, but not from the mutant, contained the 102-kDa leukotoxin protein and lysed bovine lymphoma cells and sheep erythrocytes. Wild-type P. haemolytica demonstrated the typical beta-hemolytic
G L, Murphy   +3 more
openaire   +2 more sources

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