Results 131 to 140 of about 6,004 (159)
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Leuprolide acetate‐induced leukocytoclastic vasculitis
Acta Obstetricia et Gynecologica Scandinavica, 2007Leukocytoclastic vasculitis (LCV) is a distinct clinicopathological entity with cutaneous lesions from purpuric macules to necrotic ulcers, and the other systemic manifestations, such as fever, art...
Turk, Bengu Gerceker +3 more
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Leuprolide acetate and intravascular leiomyomatosis
Obstetrics & Gynecology, 1995Intravascular leiomyomatosis is an uncommon uterine tumor characterized by grossly visible intravascular proliferation of benign smooth muscle. Based on its role in reducing the size of leiomyomas, leuprolide acetate was given as induction therapy for extensive inoperable intravascular leiomyomatosis.A 44-year-old woman, gravida 1, para 1-0-0-1 ...
D, Tresukosol +5 more
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Combination Studies with Leuprolide
European Urology, 1990The effectiveness of leuprolide (an LHRH analog), alone or in combination with flutamide (a non-steroidal antiandrogen) was tested in a double-blind multicenter study involving 603 patients with advanced prostatic cancer. The estimated median survival time was significantly longer in the patients who received combination therapy (35 months vs.
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Percutaneous Absorption Enhancement of Leuprolide
Pharmaceutical Research, 1992Chemical enhancers and vehicles were tested for their ability to improve the percutaneous absorption of leuprolide, a nonapeptide (luteinizing hormone releasing hormone analogue; MW 1209.4). In vitro permeabilities in nude mouse, snake, and cadaver skin were evaluated in either Franz diffusion cells or a Bronaugh flow-through system using an HPLC assay.
M Y, Lu, D, Lee, G S, Rao
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PEGylated leuprolide with improved pharmacokinetic properties
Bioorganic & Medicinal Chemistry, 2020Leuprolide, a gonadotropin-releasing hormone (GnRH) agonist widely used in androgen deprivation therapy for the treatment of advanced prostate cancer, suffers from a short circulating half-life like other peptide therapeutics. As an attempt to improve its pharmacokinetic properties, two PEGylated leuprolides with different molecular weight were ...
Mian, Fu +5 more
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1987
Leuprolide ([D-Leu6,Pro9-NHEt]LHRH; leuprolide) is a potent analog of the hypothalamic human gonadotropin-releasing hormone (LHRH). It is available as Lupron®, Leuprolide Acetate Injection, TAP Pharmaceuticals. The function of the naturally occurring LHRH is to regulate the release of gonadotropins from the pituitary gland.
M. B. Garnick +5 more
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Leuprolide ([D-Leu6,Pro9-NHEt]LHRH; leuprolide) is a potent analog of the hypothalamic human gonadotropin-releasing hormone (LHRH). It is available as Lupron®, Leuprolide Acetate Injection, TAP Pharmaceuticals. The function of the naturally occurring LHRH is to regulate the release of gonadotropins from the pituitary gland.
M. B. Garnick +5 more
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Leuprolide induced Myocardial Infarction
Journal of Cardiovascular Disease Research, 2016A 36-year-old premenopausal woman was admitted with acute myocardial infarction. The lady was being administered leuprolide, a GnRH agonist which suppresses FSH and LH which in turn decreases blood estrogen level for the treatment of uterine fibroid.
Vikas Mishra +8 more
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Pituitary Apoplexy After Initial Leuprolide Injection
World Neurosurgery, 2016Pituitary apoplexy is a rare complication of the initial administration of leuprolide acetate.We present the case of a 63-year-old man who experienced headache, blurred vision, and loss of consciousness after initial leuprolide treatment for prostate carcinoma.
Andrew J, Fabiano, Saby, George
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Autoimmune thyroiditis during leuprolide acetate treatment
The Journal of Pediatrics, 2004Autoimmune thyroiditis developed in a 9-year-old girl with precocious puberty approximately 8 months after initiation of Leuprolide acetate therapy. In addition, gonadotropin concentrations as measured by radioimmunoassay appeared high. Treatment with levothyroxine, in addition to continued Leuprolide acetate treatment, resolved gonadotropin elevation ...
Ori, Eyal, Susan R, Rose
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Hypersensitivity vasculitis associated with leuprolide (Lupron)
Cutaneous and Ocular Toxicology, 2010Leuprolide (Lupron) is a synthetic analog of naturally occurring gonadotropin-releasing hormone (GnRH). Leuprolide is used as a hormonal antagonist in the treatment of advanced prostatic cancer, and as hormonal therapy in the treatment of endometriosis.
Joseph, Gnanaraj, Muhammad Wasif, Saif
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