Results 21 to 30 of about 6,004 (159)

Efficacy of leuprolide acetate versus triptorelin pamoate administered every 3 months for treatment of central precocious puberty [PDF]

Clinical and Experimental Pediatrics
Background Central precocious puberty (CPP) is typically treated with gonadotropin-releasing hormone (GnRH) agonists. Although numerous GnRH agonist variants are available, limited research has compared the efficacy of leuprolide acetate and triptorelin ...
Thanaporn Thaneetrakool, Suphab Aroonparkmongkol, Nattakarn Numsriskulrat, Vichit Supornsilchai, Suttipong Wacharasindhu, Khomsak Srilanchakon   +5 more
doaj   +1 more source

Comparing the Efficacy of GnRH Agonists on the Castration Levels of Metastatic Prostate Cancer; Leuprolide Acetate 22.5 mg vs. Goserelin Acetate 10.8 mg

Bagcilar Medical Bulletin, 2023
Objective:We aimed to evaluate the effects of leuprolide 22.5 mg and goserelin 10.8 mg on castration levels in patients with metastatic prostate cancer.Method:We evaluated 50 metastatic prostate cancer patients between 01.06.2012-01.06.2014 ...
Gökhan Çil, Faruk Yağcı
doaj   +1 more source

Medical Therapies for Uterine Fibroids - A Systematic Review and Network Meta-Analysis of Randomised Controlled Trials [PDF]

, 2016
BACKGROUND: Uterine fibroids are common, often symptomatic and a third of women need repeated time off work. Consequently 25% to 50% of women with fibroids receive surgical treatment, namely myomectomy or hysterectomy.
A Armstrong, A Daniels, A Golan, A Lethaby, A Lieto, A Zimmermann, AJ Audebert, AJ Friedman, AJ Friedman, AJ Friedman, AJ Friedman, Andrew Horne, AR Williams, AR Williams, B Kroon, BJ Borah, CC Coddington, D De Aloysio, D Mavrelos, D Moher, DD Baird, DD Baird, E Roshdy, E Verspyck, E Zullo, ED Levens, EE Marsh, EK Arleo, EP Morris, ERC, A.D. Cardozo, F Parazzini, F Polatti, F Zullo, F Zullo, G Levy, G Orsini, G Salanti, GH Guyatt, GH Sayed, GS Carls, H Song, HH Bustos Lopez, Ian S. Fraser, J Balasch, J Donnez, J Donnez, J Donnez, J Gerris, J Higgins, J van de Ven, J van de Ven, J Wilkens, JB Engel, Jessica Vaughan, JH Segars, JL Esteve, JL Rutgers, K Chwalisz, K Fiscella, K Puri, KR Hodges, Kurinchi S. Gurusamy, L Deng, L Fedele, L Fedele, L Fedele, L Muzii, Lawrence M. J. Best, LJ Green, LK Nieman, M Bagaria, M De Falco, M Egger, M Engman, M Moshesh, M Rees, M Sayyah-Melli, M Tristan, MA Lumsden, ME Fernandez-Mentoli, ME Parsanezhad, MG Munro, MS Melli, N Biglia, N Johnson, N Varun, O Gregoriou, O Muneyyirci-Delale, O Sadan, P Vercellini, PG Moorman, R D'Anna, R Hudecek, R Seracchioli, RC Reinsch, RL Barbieri, RW Shaw, S Campo, S Constantini, S Jirecek, S Jo Varghese, S Palomba, S Palomba, S Palomba, S Palomba, S Palomba, S Palomba, S Palomba, S Palomba, S Palomba, SE Bulun, SL Myers, SS Lim, T Simsek, TG Stovall, TG Stovall, TG Stovall, Toby Richards, WD Schlaff, YB Baytur   +119 more
core   +4 more sources

A single-dose, randomized, open-labeled, parallel-group study comparing the pharmacokinetics, pharmacodynamics and safety of leuprolide acetate microspheres 3.75 mg and Enantone® 3.75 mg in healthy male subjects

Frontiers in Pharmacology, 2022
Leuprolide acetate microspheres developed by Shanghai Livzon Pharmaceutical Co., Ltd. (T) have been marketed in China for more than 10 years, benefiting a large number of patients, and will continue to play an important role in China.
Xingjiang Hu, Qiao Zhang, Yunliang Zheng, You Zhai, Nana Xu, Qingwei Zhao, Jian Liu, Longyan Wan, Jindan Luo   +8 more
doaj   +1 more source

Atualização em etiologia, diagnóstico e manejo da precocidade sexual [PDF]

, 2008
Precocious puberty is defined as the development of secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. Gonadotropin-dependent precocious puberty (GDPP) results from the premature activation of the hypothalamic ...
ARNHOLD, Ivo J. P., BRITO, Vinicius Nahime, LATRONICO, Ana Claudia, MENDONÇA, Berenice Bilharinho   +3 more
core   +2 more sources

A 6-month depot formulation of leuprolide acetate is safe and effective in daily clinical practice: a non-interventional prospective study in 1273 patients

BMC Urology, 2011
Background Testosterone stimulates growth in many prostate tumours. The established GnRH analogue leuprolide acetate is incorporated in a novel biodegradable polymer matrix (Atrigel® delivery system), that can be administered to reduce testosterone ...
Tunn Ulf W
doaj   +1 more source

Development of Level A In Vitro–Vivo Correlation for Electrosprayed Microspheres Containing Leuprolide: Physicochemical, Pharmacokinetic, and Pharmacodynamic Evaluation

Pharmaceutics, 2020
This study optimized the preparation of electrosprayed microspheres containing leuprolide and developed an in vitro−in vivo correlation (IVIVC) model that enables mutual prediction between in vitro and in vivo dissolution.
Dong-Seok Lee, Dong Wook Kang, Go-Wun Choi, Han-Gon Choi, Hea-Young Cho   +4 more
doaj   +1 more source

Central Precocious Puberty: Update on Diagnosis and Treatment [PDF]

, 2015
Central precocious puberty (CPP) is characterized by the same biochemical and physical features as normally timed puberty but occurs at an abnormally early age. Most cases of CPP are seen in girls, in whom it is usually idiopathic.
Chen, Melinda, Eugster, Erica A.
core   +1 more source

Pharmacokinetic–Pharmacodynamic Model for the Testosterone-Suppressive Effect of Leuprolide in Normal and Prostate Cancer Rats

Molecules, 2018
This study developed the pharmacokinetic (PK)–pharmacodynamic (PD) model of the testosterone-suppressive effect of leuprolide for evaluation of the sustained release (SR) depot and leuprolide solution in rats with or without prostate cancer.
Dong-Seok Lee, Sook-Jin Kim, Go-Wun Choi, Yong-Bok Lee, Hea-Young Cho   +4 more
doaj   +1 more source

Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome [PDF]

, 1999
BACKGROUND Women with the polycystic ovary syndrome have insulin resistance and hyperinsulinemia, possibly because of a deficiency of a d-chiro-inositol–containing phosphoglycan that mediates the action of insulin. We hypothesized that the administration
Allan, Geoffrey, , Ph. D., Gunn, Ronald D., , M.S., Jakubowicz, Daniela J., , M.D., Nestler, John E., Reamer, Paula, , M.A.   +4 more
core   +2 more sources