Results 61 to 70 of about 32,320 (312)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Global k-Level Crossing Reduction
Journal of Graph Algorithms and Applications, 2011 Summary: Directed graphs are commonly drawn by a four phase framework introduced by \textit{K. Sugiyama} et al. in 1981 [IEEE Trans. Syst., Man, Cybern. 11, No. 2, 109--125, (1981)]. The vertices are placed on parallel horizontal levels. The edge routing between consecutive levels is computed by solving one-sided 2-level crossing minimization problems,
Christian Bachmaier +3 more
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The behaviour of railway level crossings: insights through field monitoring
The development of reliable methods for measuring deflections as trains pass has enabled valuable insights into railway track behaviour to be gained.
Powrie, W. +5 more
core +1 more source
Dynamic simulation of train–truck collision at level crossings
, 2017 Trains crashing onto heavy road vehicles stuck across rail tracks are more likely occurrences at level crossings due to ongoing increase in the registration of heavy vehicles and these long heavy vehicles getting caught in traffic after partly crossing ...
Ling, Liang +3 more
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Improving Near-Miss Event Detection Rate at Railway Level Crossings
, 2015 Even though crashes between trains and road users are rare events at railway level crossings, they are one of the major safety concerns for the Australian railway industry.
Aminmansour, Sina +7 more
core +1 more source
Assessment and Management of Level Crossing Risks
Communications, 2011 The goal of the project "Assessment and Management of Level Crossing Risks" was to make a comprehensive analysis of safety of level crossings in the Moravian-Silesian Region.
Iva Zitnikova +5 more
doaj +1 more source