Results 111 to 120 of about 7,802,667 (305)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Spatial transcriptomics reveals unique metabolic profile and key oncogenic regulators of cervical squamous cell carcinoma

Journal of Translational Medicine
Background As a prevalent and deadly malignant tumor, the treatment outcomes for late-stage patients with cervical squamous cell carcinoma (CSCC) are often suboptimal.
Limin Zhou, Jiejie Liu, Peipei Yao, Xing Liu, Fei Chen, Yu Chen, Li Zhou, Chao Shen, You Zhou, Xin Du, Junbo Hu   +10 more
doaj   +1 more source

Influence of single shot and continuous peripheral nerve block on opioid consumption and perioperative pain management in patients undergoing total elbow arthroplasty

JSES International
Background: Peripheral nerve block (PNB) is effective for pain management after shoulder arthroplasty. Our study investigated the impact of regional anesthesia on perioperative pain management following total elbow arthroplasty (TEA).
Tamara Babasiz, MD, Michael Hackl, MD, PhD, Sebastian Wegmann, MD, Jan Hockmann, MD, Kai Hoffeld, MD, Lars P. Müller, MD, PhD, Tim Leschinger, MD, PhD   +6 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Association of upper thoracic motion and scapular upward rotation angle with the occurrence of traumatic shoulder dislocation in rugby players

JSES International
Background: The study aimed to elucidate the relationship between reduced thoracic elevation mobility and scapular upward rotation and the occurrence of traumatic shoulder dislocation in rugby players, as this relationship is unclear. Methods: First-year
Takuya Aso, PT, PhD, Masaki Tamura, PT, PhD, Takuya Maeda, PT, PhD, Yu Noguchi, PT, PhD, Shunya Inoue, PT, MS, Tomoyuki Takahashi, PT, MS, Shumpei Furuyama, PT, MS, Kanji Furuya, MD, PhD, Takeyuki Sambe, MD, PhD, Naoya Nishinaka, MD, PhD   +9 more
doaj   +1 more source

Quality Improvement Project to Improve Hand Hygiene Compliance in a Level III Neonatal Intensive Care Unit. [PDF]

Children (Basel), 2023
Chitamanni P, Allana A, Hand I.
europepmc   +1 more source

PRODUCTIVE SPECIALIZATION AND REGIONAL DEVELOPMENT IN PORTUGAL AT THE NUTS III LEVEL [PDF]

The purpose of this paper is to analyse how the specialization of Portuguese productive structures has evolved between 1995 and 2004, using specialization indicators, namely localization quotient estimation, to assess both the relative degree of ...
Francisco Diniz
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source