Results 291 to 300 of about 7,556,071 (335)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Primitive neuroectodermal tumor of kidney with Level III inferior vena cava thrombus.

Urol Ann, 2019
Ansari H, Banerjee I, Tomar V, Yadav SS.
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

EARLY PREDICTORS OF HOSPITAL MORTALITY IN PATIENTS WITH COVID-19 PNEUMONIA AT A LEVEL III HOSPITAL. LIMA, PERU.

, 2020
Ravelo-Hernández J, Cáceres-Bernaola U, Becerra-Nuñez C, Mendívil-Tuchia S, Vásquez-Rivas ME, Aguirre-Quispe W, Quispe-Ayuque E, Reyes-Rocha G.   +7 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Energy levels of Ho III

Physica B+C, 1976
Abstract The early analysis of Ho III has been extended, including parametric studies for complete configurations of 4f11, 4f105d, 4f106s and 4f106p, with 78 new energy levels found, including the lowest even level at 18033.4 cm−11. After optimization of real and effective parameters, the mean deviations on the energies are 32 cm−1 for 72 even levels,
Riaz Hussain, J.F. Wyart, H.M. Crosswhite   +2 more
openaire   +2 more sources

Autoionizing levels in Be III [PDF]

Journal of Physics B: Atomic and Molecular Physics, 1969
Radiative transitions from autoionizing levels of Be III were observed in the far ultra-violet spectrum produced by a vacuum spark. Classification of these transitions and determination of autoionizing level energies are given. Dependence of the intensity of these transitions on discharge parameters and the importance of the dielectronic recombination ...
openaire   +1 more source

Core Levels of III‐V Semiconductors

physica status solidi (b), 1972
AbstractThe absorption and reflection spectra of GaP, GaAs, GaSb, InP, InAs, and InSb in the region from 15 to 40 eV are presented and compared with those obtained from characteristic electron energy losses. From these data, information about the density of conduction states, the matrix elements for transitions from the outermost core levels to the ...
Gudat, W., Koch, E. E., Yu, P. Y., Cardona, M., Penchina, C. M.   +4 more
openaire   +3 more sources

Level III: Surfaces

1976
We turn now from molecules and phases to the domain of surfaces — the domain of interfacial phenomena and of colloid chemistry. When we considered molecules on Level I, we thought of them as being exposed to similar molecules on all sides; when we considered phases on Level II, we thought of them as surrounded by more of the same phase or by associated
Eugene G. Rochow, Theodore George Rochow
openaire   +2 more sources

Biological Antithrombin III Levels

JAMA: The Journal of the American Medical Association, 1978
To the Editor.— The MEDICAL NEWS article "Automated Test Measures Functional Antithrombin, Coagulation Enzymes" (report of Jayed Fareed, PhD, and Harry L. Mesmore, MD) confirms my observations 1 and those of others 2,3 that there is poor correlation between immunological (total) and functional antithrombin III levels in disease states.
openaire   +3 more sources