Nanoscale cellular organization of viral RNA and proteins in SARS-CoV-2 replication organelles
Nature CommunicationsThe SARS-CoV-2 viral infection transforms host cells and produces special organelles in many ways, and we focus on the replication organelles, the sites of replication of viral genomic RNA (vgRNA).
Leonid Andronov +9 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Service user involvement and primary care: framework document [PDF]
, 2011 Service user involvement is simply 'a process by which people are enabled to become actively and genuinely involved in defining the issues of concern to them, in making decisions about factors that affect their lives, in formulating polices, in planning,
Health Service Executive (HSE), Regional SUI Implementation Group
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IMPROVEMENT OF TRAFFIC CAPACITY FOR AL-MUSTAINSIRIYAH INTERSECTION IN BAGHDAD CITY
Al-Qadisiyah Journal for Engineering Science, 2012 Capacity and level of service are the control points of the analysis of intersections and must be fully considered to evaluate the overall operator of the intersection.
Israa F. Jasim
doaj
The criminogenic profile of violent female offenders incarcerated in Western Australian prisons as per the Level of Service/Risk, Need, Responsivity (LS/RNR) and Violence Risk Scale (VRS). [PDF]
Psychiatr Psychol Law, 2023 Gower M +3 more
europepmc +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Research Findings from Service Users and Service Providers [PDF]
, 2017 The HSE is committed to achieving a decisive shift towards stronger, more integrated Primary Care services. To identify opportunities to enhance GP and Primary Care services, a series of consultations and engagements was undertaken to understand ‘what ...
Health Service Executive (HSE)
core +1 more source
Open Computer ScienceRegulating traffic in cities plays a crucial role in addressing climate change. The rapid advancement of artificial intelligence technologies offers new opportunities for managing urban traffic within the framework of Smart Cities.
Melicherčík Miroslav +1 more
doaj +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
Forest Resources Project Beginning Level
, 1989 This archival publication may not reflect current scientific knowledge or recommendations. Current information available from the University of Minnesota Extension: https://www.extension.umn.edu.University of Minnesota Agricultural Extension Service ...
University of Minnesota Agricultural Extension Service
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