Results 231 to 240 of about 4,533,614 (299)

Center-of-gravity shift and inequality of human water use in China over the last half century. [PDF]

Sci Rep
Zhao Y, Ma Q, Jia J.
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Hospital Nurse Understaffing and Patient Mortality, Readmission, and Length of Stay.

JAMA Netw Open
Morioka N, Moriwaki M, Miyawaki A, Saville C, Fushimi K, Griffiths P.   +5 more
europepmc   +1 more source

Swiping colors in virtual reality: How stable are color category borders? [PDF]

J Vis
Aizenman AM, Goll ZR, Gil Rodriguez R, Gegenfurtner KR.   +3 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Designing life science assessments in the era of generative artificial intelligence. [PDF]

PLoS One
Kwong AC, Magnano C, DeOliveira C, Goglia C, Loparo JJ, Peters JJ.   +5 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Interactions between blood pressure variability, cerebral autoregulation, and covert cerebral small vessel disease in relation to cognitive performance in community-dwelling older adults. [PDF]

Alzheimers Dement
Chi NF, Peng LN, Lin CJ, Cheng HM, Chen CH, Wang PN, Chung CP.   +6 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Supporting paramedic sleep and fatigue: a qualitative exploration of education considerations from the early-career paramedic perspective. [PDF]

BMC Health Serv Res
Wanstall SE, Naweed A, Brown BWJ, Crowther ME, Adams RJ, Reynolds AC.   +5 more
europepmc   +1 more source