Results 241 to 250 of about 4,533,614 (299)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Dynamic level-shifting

Computers & Chemistry, 1989
Abstract An algorithm is presented for the use of a dynamic level-shifting parameter in solving SCF equations of semiempirical quantum chemical calculations. The shift parameter is changed automatically in each iteration cycle in order to reduce computation time.
Gyula Dömötör, M. I. Bán
openaire   +1 more source

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