Results 91 to 100 of about 1,102,196 (288)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Labour Productivity and Foreign Direct Investment in Irish Manufacturing Industry - A Decomposition Analysis [PDF]
Overall labour productivity in the Irish manufacturing sector increased by 158 per cent between 1991 and 1999. This paper examines the components of this labour productivity growth in the period 1991-1999, using a decomposition analysis based on plant ...
Ali Ugur, Frances Ruane
core +3 more sources
Generalized product of fuzzy subgroups and t-levelsubgroups
Mathematical Communications, 2006 Ray (Fuzzy Sets and Systems 105(1999)181-183) studiedsome results of the product of two fuzzy subsets and fuzzy subgroups.In this paper, Ray’s results will be generalized. Furthermore, we definea t-level subset and t-level subgroups, and then we study some of theirproperties.
Aktaş, H., Çağman, N.
openaire +2 more sources
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Progressive Amalgamation of Building Clusters for Map Generalization Based on Scaling Subgroups
ISPRS International Journal of Geo-Information, 2018 Map generalization utilizes transformation operations to derive smaller-scale maps from larger-scale maps, and is a key procedure for the modelling and understanding of geographic space. Studies to date have largely applied a fixed tolerance to aggregate
Xianjin He, Xinchang Zhang, Jie Yang
doaj +1 more source
On lower ramification subgroups and canonical subgroups
, 2012 Let p be a rational prime, k be a perfect field of characteristic p and K be a finite totally ramified extension of the fraction field of the Witt ring of k. Let G be a finite flat commutative group scheme over O_K killed by some p-power.
Berthelot +7 more
core +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
The Impact of Downstream Network Subgroups on Collaboration and Performance: A Survey of Buyer-Supplier Relationships in the Dutch Flower Sector [PDF]
In this paper, we aim to identify those network subgroups that enhance the collaborative governance in a focal buyer-supplier relationship. We argue, that partners in a focal buyer-supplier relationship can be seen as embedded in a broader network of ...
Claro, Danny Pimentel +3 more
core +1 more source