Results 41 to 50 of about 1,220,776 (296)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Economic Policy Uncertainty and Firm Value: The Role of Company Debt

APMBA (Asia Pacific Management and Business Application)
This study examines the impact of economic policy uncertainty (EPU) on firm value, integrating several variables to enhance the understanding of this relationship. These variables include corporate leverage, debt restructuring, and firm performance.
Syahrud Apriansyah, Kamaludin Kamaludin, Intan Zoraya, Mukti Trio Putra, Chairil Afandy   +4 more
doaj   +1 more source

PENGARUH KUALITAS AKRUAL DAN LEVERAGE TERHADAP CASH HOLDING PERUSAHAAN

Jurnal Akuntansi dan Keuangan Indonesia, 2010
This research tests the effect of accrual quality and leverage on corporate cash holding for a sample of manufacturing company listed in Indonesian Stock Exchange over the period 2006-2007. This research also tests the role of asymmetric information as a
Anggita Langgeng Wijaya, Bandi Bandi, Sri Hartoko   +2 more
doaj   +1 more source

PENGARUH LEVERAGE DAN RASIO LIKUIDITAS TERHADAP EARNING PER SHARE (Studi Pada Perusahaan Yang Tergabung Dalam Indeks LQ45) [PDF]

, 2009
Title : "Influence Leverage And Liquidity Ratio To Earning Per Share (Study At Company Merged Into By Index LQ45)". (Ekoadi Purwono, Drs. Dhaniel Syam MM, Ak, Dra. Siti Zubaidah MM, Ak).
PURWONO, EKOADI
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Leverage and Alcohol Addiction [PDF]

, 2012
This paper confronts the question of whether messages can be diluted or even contradicted by the format in which they are delivered through a textual analysis of the TNT procedural drama Leverage, examining the portrayal of alcoholism in the program. The
Gallagher, Tom
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Modern Family planning practices, male involvement and unmet fertility needs among rural and urban Nigerian women: Findings from a mixed method study in the Southwest Region

Social Medicine, 2018
Family planning (FP) utilization impacts individuals, families, communities and nations. The study aimed at comparing family planning predictors, male involvement in family planning and unmet fertility needs in rural and urban areas of Lagos, Nigeria. A
Ifeoma P. Okafor, Mobolanle R. Balogun, Adekemi O. Sekoni, Duro C. Dolapo   +3 more
doaj