Results 61 to 70 of about 201,984 (259)
Cogent Economics & Finance, 2020 The paper investigates the determinants of working capital to forecast the future requirement of working capital of BSE-listed top 150 companies in India.
Rakesh Kumar Sharma +2 more
doaj +1 more source
The capital structure of agricultural enterprises in the Visegrad countries
Agricultural Economics (AGRICECON), 2020 The Visegrad countries - or the V-4 countries: the Czech Republic, Hungary, Poland and Slovakia - is strong regional cooperation of four EU member states in Eastern-Central-Europe aimed at strengthening the positions of the members on both a European and
Veronika Fenyves +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Solving the Present Crisis and Managing the Leverage Cycle [PDF]
The present crisis is the bottom of a recurring problem that I call the leverage cycle, in which leverage gradually rises too high then suddenly falls much too low.
John Geanakoplos
core +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
We discuss how leverage can be monitored for institutions, individuals, and assets. While traditionally the interest rate has been regarded as the important feature of a loan, we argue that leverage is sometimes even more important.
Lasse H. Pedersen, John Geanakoplos
core
Risk, uncertainty, and leverage
Economic Modelling, 2020 Using mostly theoretical models and traditional risk/uncertainty measures (VIX index, panic, precaution, scary bad news, etc.), the current literature tries to clarify the risk/uncertainty-deleveraging pattern. The findings are not sufficient to explain the dynamic empirical relationship between modern risk/uncertainty indicators and leverage.
Istiak, Khandokar, Serletis, Apostolos
openaire +2 more sources
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Endogenous Leverage: VaR and Beyond [PDF]
We study endogenous leverage in a general equilibrium model with incomplete markets. We prove that in any binary tree leverage emerges in equilibrium at the maximum level such that VaR = 0, so there is no default in equilibrium, provided that agents get ...
Ana Fostel, John Geanakoplos
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source