Results 71 to 80 of about 1,220,776 (296)

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

Ownership concentration, firm life cycle, and leverage: Evidence from Italian family firms

open access: yesCogent Economics & Finance, 2020
We examine the impact of ownership concentration, firm life cycle, and family ownership on leverage using a sample of listed Italian firms. The study findings reveal that family businesses in Italy have high ownership concentration and use less debt than
William Mbanyele
doaj   +1 more source

General Equilibrium Under Convex Portfolio Constraints and Heterogeneous Risk Preferences

open access: yes, 2017
This paper characterizes the equilibrium in a continuous time financial market populated by heterogeneous agents who differ in their rate of relative risk aversion and face convex portfolio constraints.
Abbot, Tyler
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

open access: yesFEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz   +9 more
wiley   +1 more source

Leverage, Fixed Assets, and Board Characteristic on Financial Performance of Non-Cyclicals Companies

open access: yesManagement Analysis Journal
This study aims to analyze the impact of noncyclical company characteristics, board of director composition, and leverage on financial performance in Indonesia. The researcher uses quantitative research methodology to collect and analyze data.
Muhammad Rizky   +3 more
doaj   +1 more source

Firm leverage, household leverage and the business cycle [PDF]

open access: yes
This paper develops a macroeconomic model of the interaction between consumer debt and firm debt over the business cycle. I incorporate interest rate spreads generated by firm and household loan default risk into a real business cycle model.
Solomon, Bernard Daniel
core   +1 more source

Women are Africa’s largest untapped leverage [PDF]

open access: yes, 2015
https://www.researchgate.net/publication/292762682_Women_are_Africa%27s_largest_untapped_leveragePublished ...
Goncalves, Marcus
core  

Conditioning of Leverage Scores and Computation by QR Decomposition

open access: yes, 2015
The leverage scores of a full-column rank matrix A are the squared row norms of any orthonormal basis for range(A). We show that corresponding leverage scores of two matrices A and A + \Delta A are close in the relative sense, if they have large ...
Holodnak, John T.   +2 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

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