Results 111 to 120 of about 744,108 (349)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
CONTRIBUTION OF EVA LEVERAGE TO THE TOTAL LEVERAGE EFFECT ON THE COMPANY [PDF]
Challenges of the Knowledge Society, 2019 The concept of Economic Value Added (EVA) and Market Value Added (MVA) has opened up new insights into the leverage effect of fixed costs (operational leverage) and interest (financial leverage), and for determining what effects the changes in sales ...
Kristina Jančovičová BOGNÁROVÁ
doaj
The Leverage Effect Puzzle: Disentangling Sources of Bias at High Frequency [PDF]
The leverage effect refers to the generally negative correlation between an asset return and its changes of volatility. A natural estimate consists in using the empirical correlation between the daily returns and the changes of daily volatility estimated
Jianqing Fan +2 more
core
Volatility models with Leverage effect
, 2010 El objetivo de esta tesis es analizar y comparar la capacidad de algunos de los modelos habituales de series temporales para representar la volatilidad de las series financieras y sus características más importantes. En concreto, una de las principales consiste en que las series suelen presentan mayor número de observaciones extremas que las esperadas ...
openaire +3 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
The Business Cycle’s Impact on Volatility Forecasting: Recapturing Intrinsic Jump Components
RisksThis study investigates the leverage effect and realized volatility (RV) of stocks in the presence of asymmetric jumps across economic expansions and contractions.
Son-Nan Chen, Pao-Peng Hsu
doaj +1 more source
SYNERGIC EFFECT OF THE ACTION OF OPERATIONAL AND FINANCIAL RISK [PDF]
Annals of the University of Petrosani: Economics, 2014 This paper allows us to understand the complex action of total risk at microeconomic level, taking into account several factors: the area in which it acts: the operating activity, generating an economic risk, and the financing activity, generating a ...
MELANIA ELENA MICULEAC +2 more
doaj
GARCH models with leverage effect : differences and similarities [PDF]
In this paper, we compare the statistical properties of some of the most popular GARCH models with leverage effect when their parameters satisfy the positivity, stationarity and nite fourth order moment restrictions.
Esther Ruiz, María José Rodríguez
core
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source