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Levocetirizine: An Update

Current Medicinal Chemistry, 2006
Histamine plays a prominent and diverse role in the pathophysiology of allergic disease and therapeutic intervention is therefore typically focused on blocking the effects of this biogenic amine. A new antihistamine, levocetirizine, is the R-enantiomer of cetirizine dihydrochloride and like its parent compound undergoes minimal hepatic metabolism ...
openaire   +3 more sources

Development of a sensitive LC-MS/MS method for determination of N-nitrosopiperazine in levocetirizine.

Analytical Methods
Levocetirizine is one of the widely used antihistamines and has the potential to form N-nitrosopiperazine (NPZ) during drug synthesis, manufacturing, or storage.
Yujin Lim   +3 more
semanticscholar   +1 more source

Comparative Analysis of Four Brands of Levocetirizine Tablets Available in Karachi, Pakistan

International Journal of Trends in Pharmaceutical and Chemical Research, 2023
The basic purpose to prepare any drug is to increase quality of life; therefore, different quality control tests have been performed to achieve the desired outcome. One of the most frequently used dosage form is tablet which requires different techniques
Atiya Tabassum   +5 more
semanticscholar   +1 more source

Pharmacokinetic evaluation of levocetirizine

Expert Opinion on Drug Metabolism & Toxicology, 2011
There have recently been guidelines developed for the diagnosis and treatment of rhinitis and urticaria. For both conditions, second-generation antihistamines remain as the first-line therapy.The article presents the current pharmacology, chemical properties, pharmacokinetics and metabolism of levocetirizine.
openaire   +2 more sources

Analyzing the clinical efficacy and safety of levocetirizine based on its receptor occupancy, intraclass comparison and role in the treatment of CSU: an AROG consensus statement

Expert Review of Clinical Pharmacology
Introduction Chronic spontaneous urticaria (CSU) is characterized by urticaria persisting for more than 6 weeks. Antihistamines, notably sgAH (second generation antihistamines) are the first line of treatment for CSU.
K. Sardana   +11 more
semanticscholar   +1 more source

A greener RP-HPLC method for quaternary estimation of caffeine, paracetamol, levocetirizine, and phenylephrine acquiring AQbD with stability studies

Green Processing and Synthesis
The main objective of this article was to develop method and validate quaternary estimation of caffeine (CFE), paracetamol (PCM), levocetirizine (LEV), and phenylephrine (PHE) and to conduct degradation experiments using reverse-phase high-performance ...
Vineetha Rosireddy, Manikandan Krishnan
semanticscholar   +1 more source

Levocetirizine and cytokine production and apoptosis of human eosinophils

Allergy and Asthma Proceedings, 2007
Antihistamines are a common therapy for allergic symptoms. Eosinophilic infiltration is considered a hallmark of allergic inflammation. Eosinophils are capable of mediating airway mucosal damage by producing various inflammatory mediators including cytokines, chemokines, basic granule proteins, lipid mediators, and growth factors.
Mirkka Janka-Junttila   +3 more
openaire   +3 more sources

A treatment for allergic rhinitis:a view on the role of levocetirizine

Current Medical Research and Opinion, 2005
Allergic rhinitis is a significant public health concern in many developed countries. However, despite evidence for a significant impact on patients' quality of life (QoL) including sleep disruption and reduced daytime performance, allergic rhinitis remains under-managed and hence poorly controlled. This is largely owing to lack of knowledge about, and
Holgate, Stephen   +3 more
openaire   +3 more sources

Fixed drug eruption due to levocetirizine and cross-reactivity with cetirizine and hydroxyzine

Indian Journal of Drugs in Dermatology
Several drugs can act as possible causes for fixed drug eruptions (FDEs). The newer generation of antihistamines is considered safer and less prone to causing adverse drug reactions.
Ishan Agrawal   +2 more
semanticscholar   +1 more source

Multicenter Prospective Observational Study to Evaluate the Therapeutic Effect and Safety of a Combination of Montelukast and Levocetirizine for Allergic Rhinitis when Administered to Patients with Allergic Rhinitis and Asthma

International Archives of Allergy and Immunology, 2022
Introduction: Allergic rhinitis and asthma share a common inflammatory mechanism and are closely related, recognized as “one airway disease.” Thus, the guidelines recommend allergic rhinitis and asthma be treated together, and leukotriene antagonists and
Min-Hye Kim   +11 more
semanticscholar   +1 more source

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