Results 41 to 50 of about 30,754 (246)

Treatment of congenital hypothyroidism in  a  newborn with malabsorption after subtotal ileum resection

Endocrinology, Diabetes & Metabolism Case Reports, 2018
Congenital hypothyroidism requires prompt treatment to prevent adverse health outcomes. Poor intestinal levothyroxine absorption can complicate management. We present a case of a term female newborn with necrotizing enterocolitis (NEC) requiring subtotal
Charlotte S Schömig, Marie-Ève Robinson, Julia E von Oettingen   +2 more
doaj   +1 more source

Clinical, Radiologic and Cytologic Predictors of Malignancy in Pediatric Thyroid Nodules: Insights From a 26‐Year Cohort Study

Head &Neck, EarlyView.
ABSTRACT Introduction Thyroid nodules are less common but more often malignant in pediatric patients than in adults. Our objectives were to study the features of benign vs. malignant thyroid nodules in a large pediatric patient cohort. Methods Retrospective observational cohort study. Consecutive patients aged 0.01–17.9 years at evaluation between 1997–
Maxime Gest‐Laurent, Adrien Nguyen Quoc, Christine Lefevre, Laura González‐Briceño, Caroline Thalassinos, Isabelle Flechtner, Dulanjalee Kariyawasam, Yamina Dassa, Magali Viaud, Dinane Samara‐Boustani, Graziella Pinto, Hervé Monpeyssen, Sabine Sarnacki, Vincent Couloigner, Michel Polak, Athanasia Stoupa   +15 more
wiley   +1 more source

Stability of levothyroxine tablets in blister packaging versus bottles and vials under simulated in-use conditions

AAPS Open, 2022
Introduction Levothyroxine, the standard-of-care treatment for hypothyroidism, is susceptible to degradation when exposed to light and moisture and is an FDA-designated narrow therapeutic index drug. In this report, we examined how different packaging (e.
Jonathan Chun
doaj   +1 more source

Bioequivalence studies for levothyroxine [PDF]

The AAPS Journal, 2005
The Food and Drug Administration (FDA) Guidance for Bioavailability and Bioequivalence Studies for Levothyroxine has been challenged by companies that manufacture brand-name products. Their contention is that the current guidance does not adequately address the endogenous background levels of the drug, and that the ratios of the PK parameters, a basis ...
openaire   +2 more sources

Mood Disorders in Levothyroxine-Treated Hypothyroid Women

, 2019
Background: Hypothyroidism has several symptoms (weight gain, arrhythmias, mood changes, etc.). The aims of this study were (1) to assess the prevalence of anxiety and depression in levothyroxine-treated hypothyroid women and in women without ...
Benjamín Romero-Gómez, Ana Isabel Cobo-Cuenca, Juan Manuel Carmona-Torres, Blanca Notario-Pacheco, Paula Guerrero-Alonso   +4 more
core   +1 more source

Incidence and Predictors of Immune‐Related Hypothyroidism Under Pembrolizumab Across Gynecologic Malignancies and Melanoma: A Real‐World Cohort Study

International Journal of Cancer, EarlyView.
ABSTRACT Immune checkpoint inhibitors (ICIs) frequently cause thyroid immune‐related adverse events (irAEs). Permanent hypothyroidism, the clinically most relevant phenotype, requires lifelong hormone replacement. We investigated its incidence, course, risk factors, and prognostic relevance under pembrolizumab.
Freya Koffka, Johann Kornowski, Elena Laakmann, Barbara Schmalfeldt, Tim Zell, Glenn Geidel, Christoffer Gebhardt, Pia Roser, Volkmar Müller, Julian Kött   +9 more
wiley   +1 more source

Example Indication Alert for Levothyroxine.

, 2014
Example Indication Alert for Levothyroxine.
Gordon D. Schiff (321995), William L. Galanter (321998), Rachel Rosenfield (598140), Neeha Shrestha (598142), Michelle L. Bryson (598138), Bruce L. Lambert (322011), Suzanne Falck (598139), Marci Laragh (598141)   +7 more
core   +1 more source

Characteristics of participants with and without chronic levothyroxine use.

, 2021
Characteristics of participants with and without chronic levothyroxine use.
Martin Feller (361171), Pedro Marques-Vidal (58558), Cinzia Del Giovane (453921), Elisavet Moutzouri (9504465), Gérard Waeber (111536), Peter Vollenweider (93049), Patrick Walter (11858595), Oliver Grolimund (11858592), Nicolas Rodondi (174911), Camilla Janett-Pellegri (11858589), Lea Wildisen (10293695)   +10 more
core   +1 more source

Dose‐Dependent Efficacy of Radioiodine Therapy in Pediatric Graves’ Disease: A Retrospective Study of Hypothyroidism Risk and the Predictive Role of Thyroid Hormone Parameters

iRADIOLOGY, EarlyView.
RAI therapy demonstrated time‐dependent efficacy in pediatric Graves' disease, with gradually increasing treatment success and hypothyroidism incidence during follow‐up. Higher planned activity (≥ 0.15 mCi/g) was associated with a higher successful rate than lower planned activity (< 0.15 mCi/g), and LASSO analysis identified FT3 and TSH as candidate ...
Xiaoxue Tian, Dan Zhang, Yihui Wang, Lujie Cao, Junpu Jian, Jiangyan Liu, Changping Liang, Yinzhong Wang, Yonghui Chen   +8 more
wiley   +1 more source

DEVELOPMENT AND IN VITRO CHARACTERIZATION OF POLYMER-BASED NASAL FORMULATIONS OF LEVOTHYROXINE

, 2020
BACKGROUND. Hypothyroidism patients, unable to absorb oral levothyroxine rely on expensive and inconvenient intramuscular injections for life-time hormone replacement.
Esomchukwu, Vin-Boris Obinna
core