Differential H. pylori-Induced MAPK Responses Regulate Lewis Antigen Expression and Colonization Density on Gastric Epithelial Cells Between Children and Adults [PDF]
Frontiers in Immunology, 2022 Helicobacter pylori causes gastrointestinal diseases, the manifestations of diseases are more serious in adults than in children. Lewis antigen expressions on the gastric epithelium serves as receptors targeted by H. pylori.
Yao-Jong Yang +4 more
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Expression of the Carbohydrate Lewis Antigen, Sialyl Lewis A, Sialyl Lewis X, Lewis X, and Lewis Y in the Placental Villi of Patients With Unexplained Miscarriages [PDF]
Frontiers in Immunology, 2021 BackgroundLewis antigens such as Sialyl Lewis A (sLeA), Sialyl Lewis X (sLeX), Lewis X (LeX), and Lewis Y (LeY) are a class of carbohydrate molecules that are known to mediate adhesion between tumor cells and endothelium by interacting with its selectin ...
Zhi Ma +8 more
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Manipulating the Lewis antigen specificity of the cholesterol-dependent cytolysin lectinolysin [PDF]
Frontiers in Immunology, 2012 The cholesterol-dependent cytolysins (CDCs) attack cells by punching large holes in their membranes. Lectinolysin from Streptococcus mitis is unique among CDCs due to the presence of an N-terminal lectin domain that enhances the pore-forming activity of ...
Sara eLawrence +8 more
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HP1581 (WecA)-dependent O-antigen biosynthesis governs adhesion, virulence, and biofilm dynamics in Helicobacter pylori [PDF]
Frontiers in MicrobiologyBackgroundHelicobacter pylori lipopolysaccharide (LPS) contributes to bacterial fitness, immune evasion, host colonization, and virulence. The O-antigen region contains Lewis antigens and other glycans that facilitate adaptation to the gastric ...
Tram Thi Hong Nguyen +13 more
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High expression of Lewis y antigen and CD44 is correlated with resistance to chemotherapy in epithelial ovarian cancers. [PDF]
PLoS ONE, 2013 OBJECTIVES:To measure Lewis y antigen and CD44 antigen expression in epithelial ovarian carcinoma and to correlate the levels of these antigens with clinical response to chemotherapy.
Zhenhua Hu +9 more
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Co-expression of Lewis y antigen with human epididymis protein 4 in ovarian epithelial carcinoma. [PDF]
PLoS ONE, 2013 OBJECTIVE:The main aims of this study were to explore the molecular structural relationship between Human epididymis protein 4 (HE4) and Lewis y antigen by determining their expression patterns and clinical significance in ovarian epithelial carcinoma ...
Huiyu Zhuang +5 more
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Serological characteristics of Lewis antibodies and their clinical significance – A case series
Hematology, Transfusion and Cell Therapy, 2023 Introduction: Lewis antibodies have been thought to play a small role in clinical transfusion practice, but recent reports suggest that they have gained more importance in the context of transfusion and transplantation.
Rajeswari Subramaniyan
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BMC Cancer, 2022 HERPUD1 is an important early marker of endoplasmic reticulum stress (ERS) and is involved in the ubiquitination and degradation of several unfolded proteins. However, its role in tumorigenesis is seldom studied, and its role in ovarian cancer is unclear.
Xin Nie +7 more
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Clinics, 2021 OBJECTIVES: The Lewis-Y antigen is expressed in 44%-90% of breast cancers (BCs). The expression of the antigen in carcinoma tissue differs from that in normal tissues.
Laura Testa +9 more
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Asian Journal of Transfusion Science, 2020 Background: Many studies have proposed the lack of Lewis antigen as a marker for coronary artery disease (CAD); on the contrary, some of the studies found no association in this regard. This study aims to assess the association of the expression of Lewis
Ramasubramaniam Natarajan +4 more
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