Results 71 to 80 of about 1,139,909 (203)

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source

Glycans Related to the CA19-9 Antigen Are Increased in Distinct Subsets of Pancreatic Cancers and Improve Diagnostic Accuracy Over CA19-9Summary

Cellular and Molecular Gastroenterology and Hepatology, 2016
Background & Aims: The cancer antigen 19-9 (CA19-9) is the current best biomarker for pancreatic cancer, but it is not increased in approximately 25% of pancreatic cancer patients at a cut-off value that provides a 25% false-positive rate.
Huiyuan Tang, Katie Partyka, Peter Hsueh, Jessica Y. Sinha, Doron Kletter, Herbert Zeh, Ying Huang, Randall E. Brand, Brian B. Haab   +8 more
doaj   +1 more source

Lewis Antigen Phenotype and Survival of Patients With Pancreatic Cancer

, 2020
Objectives: The association of Lewis antigen phenotype with survival of patients with pancreatic ductal adenocarcinoma was investigated. Methods: A total of 1187 patients diagnosed with pancreatic ductal adenocarcinoma were evaluated in a prospective ...
박승우, 박정엽, 방승민, 송시영, 김광준, 정문재   +5 more
core   +1 more source

Melittin Reprograms Tumor‐Associated Macrophages Through CD18‐Mediated Immunomodulation

Phytotherapy Research, EarlyView.
Melittin selectively targets CD18 to deplete M2‐TAMs and remodel the TME to suppress tumor growth. ABSTRACT Tumor‐associated macrophages (TAMs), particularly the M2‐like subtype, contribute to an immunosuppressive tumor microenvironment and promote tumor progression.
Ik‐Hwan Han, Hyunju Lee, Eunbin Ko, Ilseob Choi, Soyoung Kim, Deok‐Sang Hwang, Hyunsu Bae   +6 more
wiley   +1 more source

Structural basis for Lewis antigen synthesis by the α1,3-fucosyltransferase FUT9. [PDF]

Nat Chem Biol, 2023
Kadirvelraj R, Boruah BM, Wang S, Chapla D, Huang C, Ramiah A, Hudson KL, Prudden AR, Boons GJ, Withers SG, Wood ZA, Moremen KW.   +11 more
europepmc   +1 more source

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

Phytotherapy Research, EarlyView.
Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li, Junnan Li, Guangzhi Li, Lili Huang, Tiantian Wen, Yanying Li, Yan Sun, Zhenqiang Liu, Qingshan Chen, Lili Zhang, Tiangang Lu, Ruiyan Wu, Haixue Kuang, Xiaochi Ma, Yan Liu   +14 more
wiley   +1 more source

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source

Relationship between ABO Blood Group Alleles and Pancreatic Cancer Is Modulated by Secretor (FUT2) Genotype, but Not Lewis Antigen (FUT3) Genotype. [PDF]

Cancer Epidemiol Biomarkers Prev, 2023
Kim J, Yuan C, Amundadottir LT, Wolpin BM, Pancreatic Cancer Cohort Consortium (PanScan), Klein AP, Pancreatic Cancer Case–Control Consortium (PanC4), Risch HA, Kraft P.   +8 more
europepmc   +1 more source

Interview with Arthur Lewis by Drew Lewis

, 1930
Lewis tells about how his life was impacted by the Great Depression and the after effects of Pearl Harbor. Rationing and a more militaristic atmosphere became a daily occurrence and everyone was much more patriotic.
Lewis, Arthur
core  

Astragaloside IV Restores Autophagy and Inhibits Apoptosis for Podocyte Protection in Diabetic Nephropathy by Inhibiting Notch1 Signaling via SIRT6‐Mediated Deacetylation

Phytotherapy Research, EarlyView.
AS‐IV binds to SIRT6 and promotes H3K9 deacetylation at the Notch1 promoter, inhibiting gene transcription (Created with BioGDP.com). ABSTRACT Astragaloside IV (AS‐IV) has demonstrated efficacy in ameliorating proteinuria and attenuating renal tubular damage in preclinical diabetic nephropathy (DN) models.
Qiyu Yue, Chen Yong, Xinran Wang, Yang Shu, Min Yao, Yongfei Yu, Yubai Xue, Rong Deng, Tianlu Chu, Weiwei Tao, Min Zhao, Enchao Zhou   +11 more
wiley   +1 more source