Results 251 to 260 of about 366,889 (322)

Safety, Tolerability, and Pharmacokinetics of Donanemab in Healthy Chinese Participants: A Phase 1, Randomized, Double‐Blind, Placebo‐Controlled Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Alzheimer's disease (AD), characterized by β‐amyloid (Aβ) plaques and neurofibrillary tangles, is the leading cause of dementia globally. Donanemab is a humanized immunoglobulin G1 in development as a treatment to slow AD progression. This study aimed to evaluate the safety, tolerability, pharmacokinetics (PKs), and immunogenicity of donanemab
Junyu Xu, Nan Zhao, Yihui Wang, Ivelina Gueorguieva, Chenxi Qian, Yimin Cui   +5 more
wiley   +1 more source

Evaluation of the effectiveness of a serious game titled "Kookism" on the receptive lexicon in 4-9-year-old autistic children. [PDF]

Heliyon
Hesami E, Bakhshani NM, Dahouie MA, Zaheri Y.   +3 more
europepmc   +1 more source

Foreground and Background Lexicons and Word Sense Disambiguation for Information Extraction

, 1997
Adam Kilgarriff
openalex   +2 more sources

Effect of Mild to Moderate Hepatic Impairment on Valemetostat Pharmacokinetics: An Open‐Label, Phase I Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Valemetostat tosylate (valemetostat) is a dual inhibitor of enhancer of zeste homolog (EZH) 2 and EZH1, approved in Japan for the treatment of relapsed/refractory peripheral T‐cell lymphoma and adult T‐cell leukemia/lymphoma. This Phase I, open‐label study evaluated the pharmacokinetics and safety of a single 50‐mg oral dose of valemetostat in
Masaya Tachibana, Thuy Vu Craveiro, Thomas C. Marbury, Samuel Oberstein, George J. Atiee, Ben Tao, Takako Shimizu, Yvonne Lau, Malaz A. Abutarif   +8 more
wiley   +1 more source

The Many Faces of REM Sleep Behavior Disorder. Providing Evidence for a New Lexicon. [PDF]

Eur J Neurol
Arnaldi D, Mattioli P, Orso B, Massa F, Pardini M, Morbelli S, Nobili F, Figorilli M, Casaglia E, Mulas M, Terzaghi M, Capriglia E, Malomo G, Solbiati M, Antelmi E, Pizza F, Biscarini F, Puligheddu M, Plazzi G.   +18 more
europepmc   +1 more source

LEXICALL: Lexicon Construction for Foreign Language Tutoring

, 1997
Bonnie J. Dorr
openalex   +2 more sources

Pharmacokinetics, Bioequivalence, and Safety Studies of Crisaborole Ointment in Healthy Chinese Subjects

Clinical Pharmacology in Drug Development, EarlyView.
Abstract The aim of this study was to evaluate the bioequivalence and safety of a single application of crisaborole ointment to test formulation and reference formulation in healthy subjects under fasting conditions. A total of 32 subjects were included and divided into 2 groups (test‐reference; reference‐test).
Yanchao Wang, Xiaofei Zhao, Taixin Wang, Luning Xiong, Xiujuan Liu, Jing Pan, Wen Yin, Chao Zhang, Jining Dong, Kexin Zhao   +9 more
wiley   +1 more source

Acute suicidal ideation in context: highlighting sentiment-based markers through the diary entries of a clinically depressed sample. [PDF]

BMC Psychiatry
Lekkas D, Collins AC, Heinz MV, Griffin TZ, Pillai A, Nepal SK, Mackin DM, Campbell AT, Jacobson NC.   +8 more
europepmc   +1 more source

Corpus Linguistics and the Lexicon

, 1997
Barbara Lewandowska‐Tomaszczyk
openalex   +2 more sources

Microtracer‐Based Assessment of the Mass Balance, Pharmacokinetics, and Excretion of [14C]Berzosertib, an Intravenous ATR Inhibitor, in Patients With Advanced Solid Tumors: A Phase 1 Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Berzosertib is a small‐molecule ataxia telangiectasia and Rad3‐related protein inhibitor. To assess the clearance mechanism(s) of berzosertib, a Phase 1, 2‐period, open‐label study was conducted in adults with advanced solid tumors who were treated with a single intravenous dose of 210 mg/m2 berzosertib containing approximately 3 µCi of [14C ...
Jayaprakasam Bolleddula, Holger Scheible, Florian Huber, Annick Seithel‐Keuth, Hanno Schieferstein, Deepthi S. Vagge, Nadra Mammasse, Eva Jaks, Jordi Ferrer, Camilo Moulin, Jennifer Dong, Karthik Venkatakrishnan, Zsuzsanna Papai   +12 more
wiley   +1 more source