Results 51 to 60 of about 342,042 (343)

Pharmacokinetics, Efficacy, and Safety of Upadacitinib in Pediatric Patients With Polyarticular‐Course Juvenile Idiopathic Arthritis: An Interim Analysis of an Open‐Label, Phase 1 Trial

open access: yesArthritis Care &Research, EarlyView.
Objective This work aimed to evaluate the pharmacokinetics, efficacy, and safety of upadacitinib, an oral selective JAK inhibitor, in pediatric patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods In an open‐label, phase 1 study (SELECT‐YOUTH), enrolled patients, aged 2 to <18 years with pcJIA, received body weight–based ...
Hermine I. Brunner   +12 more
wiley   +1 more source

Incidence of Side Effects Associated With Acetaminophen in People Aged 65 Years or More: A Prospective Cohort Study Using Data From the Clinical Practice Research Datalink

open access: yesArthritis Care &Research, EarlyView.
Objective The main objective of this study is to examine the safety of oral acetaminophen at its therapeutic dose in adults aged ≥65 years. Methods This population‐based cohort study used the Clinical Practice Research Datalink‐Gold data. Participants were aged ≥65 years registered with a UK general practice for at least 12 months between 1998 and 2018.
Jaspreet Kaur   +5 more
wiley   +1 more source

LexMAE: Lexicon-Bottlenecked Pretraining for Large-Scale Retrieval [PDF]

open access: yesarXiv, 2022
In large-scale retrieval, the lexicon-weighting paradigm, learning weighted sparse representations in vocabulary space, has shown promising results with high quality and low latency. Despite it deeply exploiting the lexicon-representing capability of pre-trained language models, a crucial gap remains between language modeling and lexicon-weighting ...
arxiv  

Practical and Ethical Considerations in the Effective use of Emotion and Sentiment Lexicons [PDF]

open access: yesarXiv, 2020
Lexicons of word-emotion associations are widely used in research and real-world applications. As part of my research, I have created several such lexicons (e.g., the NRC Emotion Lexicon). This paper outlines some practical and ethical considerations involved in the effective use of these lexical resources.
arxiv  

A Case‐Based Reasoning Approach to Model Manufacturing Constraints for Impact Extrusion

open access: yesAdvanced Engineering Materials, EarlyView.
A hybrid modeling approach is presented that combines constraint‐based process modeling and case‐based reasoning. The model formalizes manufacturing constraints and integrates simulation data to model complex manufacturing processes. The approach supports manufacturability analysis during product design through an adaptive modeling environment.
Kevin Herrmann   +5 more
wiley   +1 more source

Examining the relationship between cognitive inflexibility and internalizing and externalizing symptoms in autistic children and adolescents: A systematic review and meta‐analysis

open access: yesAutism Research, Volume 15, Issue 12, Page 2265-2295, December 2022., 2022
Abstract Compared to neurotypical peers, autistic adolescents show greater cognitive inflexibility (CI) which manifests at the behavioral and cognitive level and potentially increases vulnerability for the development of internalizing (INT) and externalizing (EXT) symptoms.
Jiedi Lei   +5 more
wiley   +1 more source

Investigating social interaction strategies for bootstrapping lexicon development [PDF]

open access: yes, 2003
This paper investigates how different modes of social interactions influence the bootstrapping and evolution of lexicons. This is done by comparing three language game models that differ in the type of social interactions they use.
Coumans, Hans, Vogt, Paul
core   +2 more sources

SciAgents: Automating Scientific Discovery Through Bioinspired Multi‐Agent Intelligent Graph Reasoning

open access: yesAdvanced Materials, EarlyView.
The SciAgents AI model drives hypothesis generation by harnessing multi‐agent graph reasoning, extracting insights from knowledge graphs constructed from scientific papers. Each agent plays a specific role: the Ontologist defines concepts, the Scientists draft and refine proposals, and the Critic reviews.
Alireza Ghafarollahi, Markus J. Buehler
wiley   +1 more source

Cognitive flexibility in autism: Evidence from young autistic children

open access: yesAutism Research, Volume 15, Issue 12, Page 2296-2309, December 2022., 2022
Abstract We examined the cognitive flexibility performance of young autistic children and a group of neurotypical peers. Thirty‐six autistic children (72–83 months) and 200 age‐matched typically‐developing children were assessed on the Children's Color Trails Test (CCTT), a semantic and a phonemic verbal fluency task.
Maria Andreou   +2 more
wiley   +1 more source

GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4

open access: yesJournal of Lipid Research, 2009
Glycosylphosphatidylinositol-anchored HDL-binding protein (GPIHBP1) binds both LPL and chylomicrons, suggesting that GPIHBP1 is a platform for LPL-dependent processing of triglyceride (TG)-rich lipoproteins.
William K. Sonnenburg   +15 more
doaj  

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