Results 41 to 50 of about 5,328,161 (151)

Carrier screening in the reproductive setting—Are there medical implications for the heterozygote?—A guide for clinicians

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld, Nicole Kasatkin, Bi Liu Yu, Milen Velinov, Justin S. Brandt, Elena Ashkinadze   +5 more
wiley   +1 more source

Histopathological Characterization and Differential Expression of miRNAs in Male Pediatric Patients With Lichen Sclerosus

Andrology, Volume 14, Issue 3, Page 822-832, March 2026.
ABSTRACT Background Lichen sclerosus is a chronic, inflammatory, scarring disease of the skin that manifests mostly in the genital region. Objective We studied the histomorphological characteristics, grade, and pattern of inflammation in male pediatric patients with lichen sclerosus.
Valerie Flammang, Arndt Hartmann, Robert Stöhr, Katrin Weigelt, Carol Geppert, Frederik A. Stuebs, Matthias W. Beckmann, Bernd Wullich, Helge Taubert, Marios Marcou, Sven Wach   +10 more
wiley   +1 more source

[Leydig cell hypoplasia].

Arquivos brasileiros de endocrinologia e metabologia, 2006
The Leydig cell hypoplasia is a rare and well defined form of male pseudohermaphroditism with autosomal recessive inheritance pattern. An inadequate fetal testicular Leydig cell differentiation and, consequently a low androgenic production during intra uterine and post natal periods, result in absence or incomplete virilization in patients with 46,XY ...
Ana Claudia, Latronico, Elaine Maria Frade, Costa, Berenice B, Mendonça, Ivo Jorge Prado, Arnhold   +3 more
openaire   +1 more source

Ultrasound of a prepubertal Leydig cell tumour of the testis [PDF]

, 2017
Leydig cell tumours of the testis are uncommon. They typically present in a bimodal age distribution between either 5 and 10 years of age, or 20 to 60 years of age.
Long, Gillian, Tristan Reddan, Gillian Long, Reddan, Tristan, Powell, Jennifer, Jennifer Powell   +5 more
core   +1 more source

Genomic technologies and the diagnosis of 46, XY differences of sex development

Andrology, Volume 13, Issue 5, Page 1025-1043, July 2025.
Abstract Differences/disorders of sex development can be caused by disruptions to the molecular and cellular mechanisms that control development and sex determination of the reproductive organs with 1:100 live births affected. Multiple genes are associated with 46, XY differences/disorders of sex development that can cause varying clinical phenotypes ...
Firman Idris, Andrew H. Sinclair, Katie L. Ayers   +2 more
wiley   +1 more source

Obesity, White Adipose Tissue, and Adipokines Signaling in Male Reproduction

Molecular Nutrition &Food Research, Volume 69, Issue 10, May 2025.
Role of adipokines in the hypothalamic‐pituitary‐gonadal axis (HPG) during obesity. Obesity induces structural and functional changes in WAT, with a consequent imbalance in the production and secretion of adipokines. While the adipokines adiponectin and omentin‐1 are downregulated, the adipokines leptin, resistin, vifastin, apelin, and chemerin are ...
Fabiane Ferreira Martins, Maria do Socorro Medeiros Amarante, Daiana Santana Oliveira, Isabela Macedo Lopes Vasques‐Monteiro, Vanessa Souza‐Mello, Julio Beltrame Daleprane, Christina da Silva Camillo   +6 more
wiley   +1 more source

The Genetic Landscape of Müllerian Duct Anomalies: A Comprehensive Review

Reproductive Medicine and Biology, Volume 24, Issue 1, January/December 2025.
ABSTRACT Background Müllerian duct anomalies (MDAs) are developmental malformations of the female genital tract that present as a series of abnormalities within the reproductive tracts of females. The etiology of MDAs is complex and heterogeneous, especially genetic factors.
Lin He, Shuya Chen, Yujun Sun, Zhi Zheng, Yuxiao Li, Chunfang Chu, Lin Li   +6 more
wiley   +1 more source

The Role of Silymarin in Regulating Cytokine Expression and Antioxidant Status in Testicular Tissue of Hyperglycemic Rats

Andrologia, Volume 2025, Issue 1, 2025.
This study investigated the effects of silymarin (SMN) on hyperglycemia (HPG)‐induced testicular dysfunction, focusing on cytokine expression, antioxidant and endocrine status, and spermatogenesis in a rat model. Rats were divided into three groups: control, HPG‐sole, and SMN‐treated (50 mg/kg orally).
Hossein Sheikhalislami, Masoumeh Moradi-Ozarlou, Yaser Jafari, Mazdak Razi, Karuna Sharma   +4 more
wiley   +1 more source

Clinical case seminar - Hypogonadotropic hypogonadism as a presenting feature of late-onset X-linked adrenal hypoplasia congenita [PDF]

, 2002
Mutations in the orphan nuclear receptor DAX-1 cause X-linked adrenal hypoplasia congenita. Affected boys usually present with primary adrenal failure in early infancy or childhood.
Beck-Peccoz, P, Achermann, JC, Romoli, R, Spada, A, Mantovani, G, Persani, L, Jameson, JL, Ozisik, G, Borretta, G   +8 more
core  

COUP-TFII Null Mice Display Leydig Cell Hypoplasia.

, 2013
(A) Immunohistological detection of COUP-TFII expression in the testes from adult wild type mice. Green, COUP-TFII; Blue: DAP1 (B) COUP-TFII deletion efficiency was examined by qRT-PCR. Testes were collected from the littermates.
Jun Qin (56379), Ming-Jer Tsai (72889), Sophia Y. Tsai (72890)   +2 more
core   +1 more source