Results 1 to 10 of about 12,180,903 (204)

The effects of testicular aging on Leydig cells and the application of stem cells in restoring Leydig cells function [PDF]

Reproductive Biology and Endocrinology
With the global population aging at an accelerated pace, testicular aging and its associated male health issues have garnered increasing attention. Testicular aging encompasses both age-related physiological decline and premature or pathological aging ...
Wen-bo Zhu, Han-bin Zhao, Guang-zhao Wang, Zu-long Wang, Shi-qi Wang   +4 more
doaj   +4 more sources

A Review on the Impact of Oxidative Stress and Medicinal Plants on Leydig Cells

Antioxidants, 2023
Leydig cells are essential for steroidogenesis and spermatogenesis. An imbalance in the production of reactive oxygen species (ROS) and the cellular antioxidant level brings about oxidative stress.
Chinyerum S Opuwari, Ugochukwu Offor, Kutullo Mohlala   +2 more
exaly   +2 more sources

Activation of MT1/MT2 to Protect Testes and Leydig Cells against Cisplatin-Induced Oxidative Stress through the SIRT1/Nrf2 Signaling Pathway

Cells, 2022
There is growing concern that chemotherapy drugs can damage Leydig cells and inhibit the production of testosterone. Increasing evidence shows that melatonin benefits the reproductive process. This study mainly explores the protective effect and possible
Junqiang Zhang, Yuan Fang, Dongdong Tang, Xingyu Xu, Xiaoqian Zhu, Shusheng Wu, Hui Yu, Huiru Cheng, Ting Luo, Qunshan Shen, Yang Gao, Cong Ma, Yajing Liu, Zhaolian Wei, Xiaoyu Chen, Fangbiao Tao, Xiaojin He, Yunxia Cao   +17 more
doaj   +2 more sources

The Fate of Leydig Cells in Men with Spermatogenic Failure

Life, 2022
The steroidogenic cells in the testicle, Leydig cells, located in the interstitial compartment, play a vital role in male reproductive tract development, maintenance of proper spermatogenesis, and overall male reproductive function.
Daria Adamczewska, Jolanta Słowikowska-Hilczer, Renata Walczak-Jędrzejowska   +2 more
doaj   +2 more sources

Impaired ketogenesis in Leydig Cells drives testicular aging. [PDF]

Nat Commun
Testicular aging commonly leads to testosterone deficiency and impaired spermatogenesis, yet the underlying mechanisms remain elusive. Here, we show that Leydig cells are particularly vulnerable to aging processes in testis.
Liu C, Peng H, Yu J, Luo P, Xiong C, Chen H, Fan H, Ma Y, Ou W, Zhang S, Yang C, Zhao L, Zhang Y, Guo X, Ke Q, Wang T, Deng C, Li W, Xiang AP, Xia K.   +19 more
europepmc   +2 more sources

Fetal Leydig cells dedifferentiate and serve as adult Leydig stem cells [PDF]

Development, 2018
Previous studies have established that fetal Leydig cells (FLCs) and adult Leydig cells (ALCs) show distinct functional characteristics. However, the lineage relationship between FLCs and ALCs has not been clarified yet.
Y. Shima, Kanako Miyabayashi, Tetsuya Sato, M. Suyama, Y. Ohkawa, M. Doi, H. Okamura, Kentarou Suzuki   +7 more
semanticscholar   +3 more sources

Insights into the Development of the Adult Leydig Cell Lineage from Stem Leydig Cells [PDF]

Frontiers in Physiology, 2017
Adult Leydig cells (ALCs) are the steroidogenic cells in the testes that produce testosterone. ALCs develop postnatally from a pool of stem cells, referred to as stem Leydig cells (SLCs). SLCs are spindle-shaped cells that lack steroidogenic cell markers,
Leping Ye, Xiaoheng Li, Linxi Li, Haolin Chen, R. Ge   +4 more
semanticscholar   +4 more sources

Ovarian Leydig cells and neural crests. [PDF]

Hum Cell
Abstract In our search for markers to identify and study ovarian Leydig cells, we utilized immunohistochemical techniques and visualized the results using conventional and confocal microscopy. We successfully employed steroidogenic factor-1 (SF1), androgen receptor (AR), and class III β-tubulin as markers.
Carrasco-Juan JL, Tapia O, González-Gómez M, Vega-Falcón A, García-Hernández S, Rufino-Gómez A, Méndez-Medina R, Álvarez-Arguelles Cabrera H.   +7 more
europepmc   +3 more sources

The roles and mechanisms of Leydig cells and myoid cells in regulating spermatogenesis

Cellular and Molecular Life Sciences, 2019
Yiqun Jiang, Wei Chen, Zuping He
exaly   +2 more sources

Exposure to nanoplastics induces mitochondrial impairment and cytomembrane destruction in Leydig cells.

Ecotoxicology and Environmental Safety, 2023
Plastic particle pollution poses an emerging threat to ecological and human health. Laboratory animal studies have illustrated that nano-sized plastics can accumulate in the testis and cause testosterone deficiency and spermatogenic impairment.
Z. Sun, Yiqian Wen, Fan Zhang, Zhendong Fu, Yangyang Yuan, Hai-Bin Kuang, Xiaodong Kuang, Jian Huang, Li-Ping Zheng, Da-Lei Zhang   +9 more
semanticscholar   +1 more source