Results 21 to 30 of about 16,604,758 (298)

Mitochondrial ROS-mediated ribosome stalling and GCN2 activation are partially involved in 1-nitropyrene-induced steroidogenic inhibition in testes

Environment International, 2022
In the past 50 years, testosterone (T) level in men has declined gradually. In this research, we discovered that acute exposure to 1-nitropyrene (1-NP), an environmental stressor from polluted atmosphere, reduced T contents by downregulating ...
Jian Li, Lan Gao, Jing Chen, Wei-Wei Zhang, Xiao-Yi Zhang, Bo Wang, Cheng Zhang, Yan Wang, Yi-Chao Huang, Hua Wang, Wei Wei, De-Xiang Xu   +11 more
doaj   +1 more source

FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice

Aging, 2020
Male late-onset hypogonadism is an age-related disease, the core mechanism of which is dysfunction of senescent Leydig cells. Recent studies have shown that elimination of senescent cells can restore proper homeostasis to aging tissue.
Chi Zhang, Yun Xie, Hai-Cheng Chen, Linyan Lv, Jiahui Yao, Min Zhang, Kai Xia, Xin Feng, Yanqing Li, Xiao-Yan Liang, Xiang-Zhou Sun, Chunhua Deng, Gui-Hua Liu   +12 more
semanticscholar   +1 more source

Short-term perfluorooctane sulfonate exposure impairs Leydig cell regeneration in the adult rat testis via targeting hedgehog signaling

Ecotoxicology and Environmental Safety, 2021
Perfluorooctane sulfonate is related to male reproductive dysfunction in rats and humans. However, the underlying mechanism remains unknown. Here, we reported the effects of short-term exposure to perfluorooctane sulfonate on the regeneration of Leydig ...
Baiping Mao, Chao Li, Zina Wen, Huitao Li, Yiyan Wang, Lanlan Chen, Qingquan Lian, Ren-Shan Ge   +7 more
doaj   +1 more source

Regulation of seminiferous tubule-associated stem Leydig cells in adult rat testes

Proceedings of the National Academy of Sciences of the United States of America, 2016
Haolin Chen, June Liu, Xiaoheng Li
exaly   +2 more sources

Leydig Cells in the Adult Testis: Characterization, Regulation and Potential Applications.

Endocrine reviews, 2020
Androgen deficiency (hypogonadism) affects males of all ages. Testosterone replacement therapy (TRT) is effective in restoring serum testosterone and relieving symptoms.
Pan-Pan Chen, B. Zirkin, Haolin Chen
semanticscholar   +1 more source

Bone morphogenetic protein 4 inhibits rat stem/progenitor Leydig cell development and regeneration via SMAD-dependent and SMAD-independent signaling

Cell Death and Disease, 2022
Bone morphogenetic protein 4 (BMP4) is an important member of the transforming growth factor-β superfamily. BMP4 is expressed in the Leydig cell lineage. We hypothesized that BMP4 might regulate the development of stem/progenitor Leydig cells.
Xiaoheng Li, Yinghui Fang, Lanlan Chen, Hehua Quan, Yiyan Wang, Ren-Shan Ge   +5 more
doaj   +1 more source

Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells

Cell Death and Disease, 2020
Abnormal lipid/lipoprotein metabolism induced by obesity may affect spermatogenesis by inhibiting testosterone synthesis in Leydig cells. It is crucial to determine which components of lipoproteins inhibit testosterone synthesis. Circulating oxidized low-
Jun Jing, Ning Ding, Dandan Wang, Xie Ge, Jin-Zhao Ma, Rujun Ma, Xuan Huang, Kadiliya Jueraitetibaike, Kuan Liang, Shuxian Wang, Siyuan Cao, A. Zhao, B. Yao   +12 more
semanticscholar   +1 more source

Dexamethasone suppresses the differentiation of stem Leydig cells in rats in vitro

BMC Pharmacology and Toxicology, 2019
Background It is an established fact that excess of glucocorticoids could cause the harmful effects, such as suppression on the male reproduction. Although glucocorticoids pharmacologically inhibit the Leydig cell function, their roles in Leydig cell ...
Jingwei Zhang, Guanghui Hu, Bisheng Huang, Dong Zhuo, Yujie Xu, Huitao Li, Xiangcheng Zhan, Ren-Shan Ge, Yunfei Xu   +8 more
doaj   +1 more source

Testosterone secretion is affected by receptor tyrosine kinase c-Kit and anoctamin 1 activation in mouse Leydig cells

Journal of Animal Reproduction and Biotechnology, 2022
Receptor tyrosine kinase c-Kit, a marker found on interstitial cells of Cajal (ICCs), is expressed in Leydig cells, which are testicular interstitial cells. The expression of other ICC markers has not yet been reported. In this study, we investigated the
Eun-A Ko, Min Seok Woo, Dawon Kang
doaj   +1 more source

Vitamin A Promotes Leydig Cell Differentiation via Alcohol Dehydrogenase 1

Frontiers in Endocrinology, 2018
Vitamin A (retinol) is important for multiple functions in mammals. In testis, the role of vitamin A in the regulation of testicular functions is clearly involved in rodents. It is essential for sperm production.
Yan Yang, Yan Yang, Jiao Luo, Dan Yu, Tiantian Zhang, Qilian Lin, Quan Li, Xupeng Wu, Zhijian Su, Qihao Zhang, Qi Xiang, Qi Xiang, Yadong Huang, Yadong Huang   +13 more
doaj   +1 more source