Results 41 to 50 of about 16,604,758 (298)

Silencing of MEG3 attenuated the role of lipopolysaccharides by modulating the miR-93-5p/PTEN pathway in Leydig cells

Reproductive Biology and Endocrinology, 2021
Background Leydig cells reflect the activation of inflammation, decrease of androgen production, inhibition of cell growth and promotion of cell apoptosis under orchitis. Maternally expressed gene 3 (MEG3) exerts a crucial role in various human diseases,
Xu Zhou, Jingliang He, Jinbo Chen, Yu Cui, Zhenyu Ou, Xiongbing Zu, Nenghui Liu   +6 more
doaj   +1 more source

scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells

Cells, 2020
In December 2019, a novel coronavirus (SARS-CoV-2) was identified in COVID-19 patients in Wuhan, Hubei Province, China. SARS-CoV-2 shares both high sequence similarity and the use of the same cell entry receptor, angiotensin-converting enzyme 2 (ACE2 ...
Zhengpin Wang, Xiao-Jiang Xu
semanticscholar   +1 more source

Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors [PDF]

, 2010
Follicle stimulating hormone (FSH) and androgen act to stimulate and maintain spermatogenesis. FSH acts directly on the Sertoli cells to stimulate germ cell number and acts indirectly to increase androgen production by the Leydig cells.
Abel, M.H., Verhoeven, G., De Gendt, K., Monteiro, A., O'Shaughnessy, P.J.   +4 more
core   +1 more source

SARS-CoV-2 Enters Human Leydig Cells and Affects Testosterone Production In Vitro

, 2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a SARS-like coronavirus, continues to produce mounting infections and fatalities all over the world. Recent data point to SARS-CoV-2 viral infections in the human testis.
Lu Li, Joseph L. Mankowski, Paula M. Cannon, Vassilios Papadopoulos, Yuchang Li, Haoyi Cui, Jason S. Villano, Chantal M. Sottas, Hsu-Yu Chen   +8 more
core   +1 more source

Use of novel serum markers in clinical follow-up of Sertoli-Leydig cell turnours [PDF]

, 2007
Background: Sertoli-Leyclig cell tumours of the ovary account for only 0.2% of malignant ovarian tumours. Two-thirds of all patients become apparent due to the tumour's hormone production. Methods: A 41-year-old patient (gravida 4, para 4) presented with
Kuemper, Caroline, Diebold, Joachim, Lenhard, Miriam, Ditsch, Nina, Friese, Klaus, Burges, Alexander, Stieber, Petra   +6 more
core   +1 more source

Triadimefon increases fetal Leydig cell proliferation but inhibits its differentiation of male fetuses after gestational exposure

Ecotoxicology and Environmental Safety, 2021
Triadimefon is a broad-spectrum fungicide widely applied in the agriculture. It is believed to be an endocrine disruptor. Whether triadimefon can inhibit the development of fetal Leydig cells and the underlying mechanisms are unknown.
Liben Lin, Qiang Xu, Quanxu Chen, Haiqiong Chen, Yingfen Ying, Zengqiang Li, Song Zhang, Feifei Ma, Yige Yu, Ren-Shan Ge   +9 more
doaj   +1 more source

Effects of FSH on testicular mRNA transcript levels in the hypogonadal mouse [PDF]

, 2009
Follicle stimulating hormone (FSH) acts through the Sertoli cell to ensure normal testicular development and function. To identify transcriptional mechanisms through which FSH acts in the testis we have treated gonadotrophin-deficient hypogonadal (hpg ...
Abel, M.H., Lee, S., Charlton, H.M., O'Shaughnessy, P.J., Baban, D.   +4 more
core   +1 more source

Jagged1 intracellular domain modulates steroidogenesis in testicular Leydig cells.

PLoS ONE, 2020
Leydig cells represent the steroidogenic lineage of mammalian testis, which produces testosterone. Genetic evidence indicates the requirement of Notch signaling in maintaining a balance between differentiated Leydig cells and their progenitors during ...
Sudeep Kumar, Hee-Sae Park, Keesook Lee
doaj   +1 more source

Numeric and volumetric changes in Leydig cells during aging of rats [PDF]

Acta Cirúrgica Brasileira, 2017
Purpose: To analyze the effects of aging in rats on the nuclear volume, cytoplasmic volume, and total volume of Leydig cells, as well as their number.
Bruno Vinicius Duarte Neves, Fernando Lorenzini, Djanira Veronez, Eduardo Pereira de Miranda, Gabriela Duarte Neves, Rogério de Fraga   +5 more
doaj   +1 more source

A Novel Model Using AAV9-Cre to Knockout Adult Leydig Cell Gene Expression Reveals a Physiological Role of Glucocorticoid Receptor Signalling in Leydig Cell Function

, 2022
Glucocorticoids are steroids involved in key physiological processes such as development, metabolism, inflammatory and stress responses and are mostly used exogenously as medications to treat various inflammation-based conditions.
Darbey, Annalucia LL, Sarah Smith, Lawrence, Ben M., Parameswaran, Shanmathi, Shanmathi Parameswaran, Liza O’Donnell, Annalucia L. Darbey, O'Donnell, Liza, Joanna Kelso, Smith, Lee B., Rebourcet, Diane, Chensee, Grace, Smith, Lee BB, Anne-Louise Gannon, Lawrence, Ben MM, Darbey, Annalucia L., Natalie Reed, Lee B. Smith, Kelso, Joanna, Diane Rebourcet, Gannon, Anne-Louise, Smith, Sarah, Ben M. Lawrence, Reed, Natalie, O’Donnell, Liza, Grace Chensee   +25 more
core   +1 more source