Results 51 to 60 of about 16,604,758 (298)

Leydig cell aging and hypogonadism [PDF]

Experimental Gerontology, 2015
Leydig cell testosterone (T) production is reduced with age, resulting in reduced serum T levels (hypogonadism). A number of cellular changes have been identified in the steroidogenic pathway of aged Leydig cells that are associated with reduced T formation, including reductions in luteinizing hormone (LH)-stimulated cAMP production, the cholesterol ...
M C, Beattie, L, Adekola, V, Papadopoulos, H, Chen, B R, Zirkin   +4 more
openaire   +2 more sources

Leukemia inhibitory factor-receptor signalling negatively regulates gonadotrophin-stimulated testosterone production in mouse Leydig Cells

, 2022
Testicular Leydig cells (LCs) are the principal source of circulating testosterone in males. LC steroidogenesis maintains sexual function, fertility and general health, and is influenced by various paracrine factors.
Curley, M, Smith, LB, Rebourcet, D, O'Donnell, L, Wilson, K, Mitchell, RT, Kilcoyne, KR, Mungall, W, Darbey, A, Guo, J   +9 more
core   +1 more source

Characterization of stem cells associated with seminiferous tubule of adult rat testis for their potential to form Leydig cells

Stem Cell Research, 2019
Adult testicular Leydig cells arise from stem cells in the neonatal and adult testis. The nature of these stem Leydig cells (SLCs) have not been well characterized.
Xiaoju Guan, Panpan Chen, Xingxing Zhao, Xinrui Hao, Fenfen Chen, Minpeng Ji, Xin Wen, Han Lin, Leping Ye, Haolin Chen   +9 more
doaj   +1 more source

Autophagy regulates testosterone synthesis by facilitating cholesterol uptake in Leydig cells

Journal of Cell Biology, 2018
Testosterone is indispensable for sexual development and maintaining male characteristics, and deficiency of this hormone results in primary or late-onset hypogonadism (LOH).
Fengyi Gao, Guo-Ping Li, Chao Liu, Hui Gao, Hao Wang, Weixiao Liu, Min Chen, Yongliang Shang, Lina Wang, Jian Shi, Wenlong Xia, Jian-Wei Jiao, Fei Gao, Jian Li, Liang Chen, Wei Li   +15 more
semanticscholar   +1 more source

Enniatin B1 induces damage to Leydig cells via inhibition of the Nrf2/HO-1 and JAK/STAT3 signaling pathways

Ecotoxicology and Environmental Safety
Enniatin B1 (ENN B1) is a mycotoxin that can be found in various foods. However, whether ENN B1 is hazardous to the reproductive system is still elusive.
Hongping Shen, Yili Cai, Keqi Zhu, Dong Wang, Rui Yu, Xueqin Chen   +5 more
doaj   +1 more source

Stimulation of TM3 Leydig cell proliferation via GABA_A receptors: A new role for testicular GABA

Reproductive Biology and Endocrinology, 2004
The neurotransmitter gamma-aminobutyric acid (GABA) and subtypes of GABA receptors were recently identified in adult testes. Since adult Leydig cells possess both the GABA biosynthetic enzyme glutamate decarboxylase (GAD), as well as GABAA and GABAB ...
Krieger Annette, Thalhammer Andrea, Doepner Richard FG, Geigerseder Christof, Mayerhofer Artur   +4 more
doaj   +1 more source

Disruption of androgen metabolism, regulation and effects : involvement of steroidogenic enzymes [PDF]

, 2014
Communication between organs and tissues is predominately controlled by hormones. Hormones regulate a vast variety of physiological and behavioural activities, including metabolism, growth and development, reproduction, sleep and mood.
Fürstenberger, Cornelia
core   +1 more source

Use of in vitro methodology to investigate phthalate effects on the differentiation of seminiferous tubule-associated stem cells to form Leydig cells and on the Leydig cells derived from the stem cells

Frontiers in Toxicology
Introduction: Leydig cells isolated from the testis are able to sustain high levels of testosterone production in vitro, but only for up to 3 days. Such cells are valuable for addressing the acute effects of chemicals on steroidogenic function, but not ...
Kassim Traore, Kassim Traore, Barry Zirkin   +2 more
doaj   +1 more source

Development of fetal and adult Leydig cells

Reproductive Medicine and Biology, 2019
In mammals, two distinct Leydig cell populations, fetal Leydig cells (FLCs) and adult Leydig cells (ALCs), appear in the prenatal and postnatal testis, respectively.
Y. Shima
semanticscholar   +1 more source

Direct action through the Sertoli cells is essential for androgen stimulation of spermatogenesis [PDF]

, 2010
Androgens act to stimulate spermatogenesis through androgen receptors (AR) on the Sertoli cells and peritubular myoid cells (PTM). Specific ablation of the AR in either cell type will cause a severe disruption of spermatogenesis.
Abel, M.H., Verhoeven, G., De Gendt, K., Monteiro, A., O'Shaughnessy, P.J.   +4 more
core   +1 more source