Results 81 to 90 of about 21,083 (177)

Identification of Compound Heterozygous CYP11A1 Variants via Reanalysis of Clinical Sequencing Data

American Journal of Medical Genetics Part A, Volume 200, Issue 4, Page 923-928, April 2026.
ABSTRACT A molecular diagnosis is currently achievable in approximately 50% of patients assessed by clinical geneticists at tertiary care centres. Next‐Generation Sequencing Panels contain a defined group of genes associated with a clinically defined set of phenotypes.
Ana Acosta Bedón, Vahid Akbari, Ralph Rothstein, Alexandra Inman, Sanjiv Bhalla, Jianghong An, Jan M. Friedman, Rosanna Weksberg, Cornelius Boerkoel, Steven J. M. Jones, William T. Gibson   +10 more
wiley   +1 more source

Folate receptor alpha (FRα) expression in tubo‐ovarian and endometrial tumors: a study of 923 cases

The Journal of Pathology: Clinical Research, Volume 12, Issue 2, March 2026.
Abstract Folate receptor alpha (FRα) is a promising therapeutic target due to its high expression in several tumor types and its rare expression in healthy tissue. Recently, the antibody‐drug conjugate mirvetuximab soravtansine has been approved for treatment of advanced platinum‐resistant high‐grade serous carcinoma (HGSC).
Isabela Töltési, Kristýna Němejcová, Michaela Kendall Bártů, Romana Vránková, David Cibula, Pavel Fabian, Filip Frühauf, Jitka Hausnerová, Jan Laco, Gábor Méhes, Zuzana Špůrková, Marián Švajdler, Radoslav Matěj, Pavel Dundr   +13 more
wiley   +1 more source

Sertoli–Leydig cell tumor of the ovary: A diagnostic dilemma

Gynecologic Oncology Reports, 2016
Background: Sertoli–Leydig cell tumors are rare sex-cord stromal tumors of the ovary that can present with a variety of histological elements, which may complicate diagnosis and treatment.
Casandra A. Liggins, Ly T. Ma, Matthew P. Schlumbrecht   +2 more
doaj   +1 more source

Comparative cytotoxicity study of nicotine and cotinine on MRC-5 cell line [PDF]

, 2018
Nicotine has several health hazards regarding carcinogenic potential. It also imparts increased risk for respiratory, cardiovascular, and gastrointestinal disorders.
Baconi, Daniela Luiza, Balalau, Cristian, Galateanu, Bianca, Stan, Miriana, Vlasceanu, Ana-Maria   +4 more
core   +4 more sources

Targeting the CMKLR1‐Mediated Signaling Rebalances Immunometabolism State in Middle‐Age Testicular Macrophages

Advanced Science, Volume 13, Issue 14, 9 March 2026.
In middle age, testicular CMKLR1⁺ macrophages exhibited a pro‐inflammatory immunometabolic profile, mediated by adipose signals associated with high BMI. However, inhibition of CMKLR1 signaling, either through Cmklr1 genetic ablation or treatment with a CMKLR1 antagonist peptide, can reverse this phenotype.
Zhendong Zhu, Feifei Du, Yang Liu, Jinchunzi Yang, Lei Ge, Tianxia Xiao, Mengxia Li, Jie Chen, Jia Tang, Yali Yang, Jian V. Zhang   +10 more
wiley   +1 more source

An Investigation of Hyperostosis Frontalis Interna in a Modern Anatomical Body Donor Population

Clinical Anatomy, Volume 39, Issue 2, Page 211-233, March 2026.
ABSTRACT This research sought to examine the prevalence and severity of hyperostosis frontalis interna (HFI) in the Chicagoland anatomical body donor population. The study further aimed to elucidate potential demographic risk factors for HFI, including sex, age at death, and structural vulnerability index (SVI), as well as any common comorbidities, as ...
Amy C. Beresheim, Amanda Hall
wiley   +1 more source

Stimulation of TM3 Leydig cell proliferation via GABA receptors: A new role for testicular GABA [PDF]

, 2004
The neurotransmitter gamma-aminobutyric acid (GABA) and subtypes of GABA receptors were recently identified in adult testes. Since adult Leydig cells possess both the GABA biosynthetic enzyme glutamate decarboxylase (GAD), as well as GABAA and GABAB ...
Krieger Annette, Thalhammer Andrea, Doepner Richard FG, Geigerseder Christof, Mayerhofer Artur   +4 more
core   +1 more source

Pattern and Clinical Significance of CA19‐9 Expression in Human Cancer: A Tissue Microarray Study on 14,966 Tumors

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Carbohydrate antigen 19–9 (CA19‐9) is a cell surface glycoprotein widely used as a diagnostic and prognostic serum marker for monitoring pancreatic cancer. The aim of this study was to evaluate the prevalence and clinical relevance of CA19‐9 expression in human cancer. Methods To comprehensively determine the prevalence and clinical
Nina Schraps, Anne Menz, Florian Viehweger, Seyma Büyücek, David Dum, Ria Schlichter, Andrea Hinsch, Christoph Fraune, Christian Bernreuther, Martina Kluth, Claudia Hube‐Magg, Katharina Möller, Viktor Reiswich, Andreas M. Luebke, Patrick Lebok, Sören Weidemann, Guido Sauter, Maximilian Lennartz, Frank Jacobsen, Till S. Clauditz, Andreas H. Marx, Ronald Simon, Stefan Steurer, Baris Mercanoglu, Nathaniel Melling, Thilo Hackert, Eike Burandt, Natalia Gorbokon, Sarah Minner, Till Krech, Florian Lutz, Morton Freytag   +31 more
wiley   +1 more source

Lipid composition and gonadotropin-mediated lipid metabolism of the M5480 murine Leydig cell tumor

Journal of Lipid Research, 1980
The effects of human choriogonadotropin (HCG) stimulation on lipid composition in the murine Leydig cell tumor M5480 grown subcutaneously were determined.
D H Albert, M Ascoli, D Puett, J G Coniglio   +3 more
doaj   +1 more source

Luteinizing hormone induces expression of 11beta-hydroxysteroid dehydrogenase type 2 in rat Leydig cells [PDF]

, 2009
Background Leydig cells are the primary source of testosterone in male vertebrates. The biosynthesis of testosterone in Leydig cells is strictly dependent on luteinizing hormone (LH).
Qian Wang, Ping Zhang, Hui-Bao Gao
core   +2 more sources