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SARS-CoV-2 exploits steroidogenic machinery, triggers lipid metabolism for viral replication and induces immune response in Leydig cells of K18-hACE2 mice. [PDF]

open access: yesFront Cell Infect Microbiol
de Oliveira SA   +6 more
europepmc   +1 more source
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Leydig Cell and Spermatogenesis

2021
Leydig cells of the testis have the capacity to synthesize androgen (mainly testosterone) from cholesterol. Adult Leydig cells are the cell type for the synthesis of testosterone, which is critical for spermatogenesis. At least four steroidogenic enzymes take part in testosterone synthesis: cytochrome P450 cholesterol side chain cleavage enzyme, 3β ...
Ren-Shan, Ge, Xiaoheng, Li, Yiyan, Wang
openaire   +2 more sources

Leydig Cell Function

1983
The role of the testis in the development of masculine features has been known for literally thousands of years. It is, however, only within the past 150 years that we have begun to understand how the testes have these effects. The location and appearances of the cells that now bear his name were first described by Von Leydig in 1857.
Y, Hodgson, B, Hudson
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Leydig Cells

2018
Leydig cells (LC) are present in the testicular interstitial tissue, and their main function is to produce testosterone (T) for the maintenance of spermatogenesis and extratesticular androgenic and anabolic functions. LC appear in fetal life, and their hormonal products (T and INSL3) direct male fetal masculinization and early development of genital ...
Huhtaniemi, I., Teerds, K.J.
openaire   +1 more source

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