Results 31 to 40 of about 297,688 (240)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

USO DA ÁGUA SUBTERRÂNEA NO ABASTECIMENTO DA POPULAÇÃO RURAL DOS MUNICÍPIOS DA BACIA DO RIO SÃO JOSÉ DOS DOURADOS

Revista Águas Subterrâneas, 2015
A crescente utilização da água subterrânea reflete-se do aumento populacional na busca do suprimento das demandas por água. Em muitas regiões do mundo o manancial subterrâneo representa a principal fonte de abastecimento de água da população rural.
Marcelo Marconato Prates, Josiane Lourencetti, Jefferson Nascimento de Oliveira   +2 more
doaj  

Profile of gonadotropic hormone secretion in sheep with disturbed rhythm of seasonality

Czech Journal of Animal Science, 2017
The effect of artificial conditions of a short daylight period (16 h darkness (D): 8 h light (L)) and exogenous melatonin on milk yield parameters of sheep during spring and summer was examined to determine the impact of using sheep for milk on the ...
Edyta Molik, Michał Błasiak, Tomasz Misztal, Katarzyna Romanowicz, Dorota A. Zięba   +4 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

O USO DO SERRA GERAL NO ESTADO DO MATO GROSSO DO SUL

Revista Águas Subterrâneas, 2011
O Estado de Mato Grosso do Sul é rico tanto em recursos hídricos superficiais quanto em subterrâneos. A captação de águas subterrâneas se mostrou crescente nas últimas décadas, chegando a ser superior a água superficial.
Caroline Aparecida de Almeida Silva, Jefferson Nascimento de Oliveira   +1 more
doaj  

IL-1 Receptor Antagonist Anakinra Inhibits the Effect of IL-1β- Mediated Osteoclast Formation by Periodontal Ligament Fibroblasts

Biology
Rheumatoid arthritis and periodontitis are comorbidities that share mutual pathways. IL-1β is a pro-inflammatory cytokine that plays a crucial role in both diseases.
Elizabeth Steemers, Wael M. I. Talbi, Jolanda M. A. Hogervorst, Ton Schoenmaker, Teun J. de Vries   +4 more
doaj   +1 more source

Serotonin, GnRH-A, and dopamine interaction in the control of in vivo luteinizing hormone release in Prussian carp (Carassius gibelio Bloch) at the time of gonad recrudescence

Czech Journal of Animal Science, 2015
The effects of serotonin (5-HT), GnRH analogue (D-Ala6 LHRH, GnRH-A) and dopamine antagonist - pimozide (PIM), on luteinizing hormone (LH) release in mature Prussian carp female (Carassius gibelio Bloch) were examined at the time of gonad recrudescence ...
M. Sokolowska-Mikolajczyk, D. Gajdzinski, G. Gosiewski, M. Socha   +3 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

O USO DA FORMAÇÃO BAURU NO MATO GROSSO DO SUL

Revista Águas Subterrâneas, 2011
A captação de águas subterrâneas da Formação Bauru se mostrou crescente nas últimas décadas, chegando a ser superior a água superficial. Alguns municípios do estado são parcialmente ou totalmente abastecidos por águas subterrâneas.
Caroline Aparecida de Almeida Silva, Jefferson Nascimento de Oliveira   +1 more
doaj  

The gene expression profile and cell of origin of canine peripheral T-cell lymphoma

BMC Cancer
Background Peripheral T-cell lymphoma (PTCL) refers to a heterogenous group of T-cell neoplasms with poor treatment responses and survival times. Canine PTCL clinically and immunophenotypically resembles the most common human subtype, PTCL-not otherwise ...
Eileen Owens, Lauren Harris, Adam Harris, Janna Yoshimoto, Robert Burnett, Anne Avery   +5 more
doaj   +1 more source