Results 41 to 50 of about 1,196,187 (326)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

USO DA ÁGUA SUBTERRÂNEA NO ABASTECIMENTO DA POPULAÇÃO RURAL DOS MUNICÍPIOS DA BACIA DO RIO SÃO JOSÉ DOS DOURADOS

Revista Águas Subterrâneas, 2015
A crescente utilização da água subterrânea reflete-se do aumento populacional na busca do suprimento das demandas por água. Em muitas regiões do mundo o manancial subterrâneo representa a principal fonte de abastecimento de água da população rural.
Marcelo Marconato Prates, Josiane Lourencetti, Jefferson Nascimento de Oliveira   +2 more
doaj  

IL-1 Receptor Antagonist Anakinra Inhibits the Effect of IL-1β- Mediated Osteoclast Formation by Periodontal Ligament Fibroblasts

Biology
Rheumatoid arthritis and periodontitis are comorbidities that share mutual pathways. IL-1β is a pro-inflammatory cytokine that plays a crucial role in both diseases.
Elizabeth Steemers, Wael M. I. Talbi, Jolanda M. A. Hogervorst, Ton Schoenmaker, Teun J. de Vries   +4 more
doaj   +1 more source

Profile of gonadotropic hormone secretion in sheep with disturbed rhythm of seasonality

Czech Journal of Animal Science, 2017
The effect of artificial conditions of a short daylight period (16 h darkness (D): 8 h light (L)) and exogenous melatonin on milk yield parameters of sheep during spring and summer was examined to determine the impact of using sheep for milk on the ...
Edyta Molik, Michał Błasiak, Tomasz Misztal, Katarzyna Romanowicz, Dorota A. Zięba   +4 more
doaj   +1 more source

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

Static polarizability of two-dimensional hole gases

, 2010
We have calculated the density-density (Lindhard) response function of a homogeneous two-dimensional (2D) hole gas in the static (omega=0) limit. The bulk valence-band structure comprising heavy-hole (HH) and light-hole (LH) states is modeled using ...
Bastard G, Michele Governale, Schliemann J, Thomas Kernreiter, Ulrich Zülicke, Winkler R, Yu P Y, Ziman J M   +7 more
core   +1 more source

O USO DO SERRA GERAL NO ESTADO DO MATO GROSSO DO SUL

Revista Águas Subterrâneas, 2011
O Estado de Mato Grosso do Sul é rico tanto em recursos hídricos superficiais quanto em subterrâneos. A captação de águas subterrâneas se mostrou crescente nas últimas décadas, chegando a ser superior a água superficial.
Caroline Aparecida de Almeida Silva, Jefferson Nascimento de Oliveira   +1 more
doaj  

Serotonin, GnRH-A, and dopamine interaction in the control of in vivo luteinizing hormone release in Prussian carp (Carassius gibelio Bloch) at the time of gonad recrudescence

Czech Journal of Animal Science, 2015
The effects of serotonin (5-HT), GnRH analogue (D-Ala6 LHRH, GnRH-A) and dopamine antagonist - pimozide (PIM), on luteinizing hormone (LH) release in mature Prussian carp female (Carassius gibelio Bloch) were examined at the time of gonad recrudescence ...
M. Sokolowska-Mikolajczyk, D. Gajdzinski, G. Gosiewski, M. Socha   +3 more
doaj   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Use of Ovulation Predictor Kits as Adjuncts When Using Fertility Awareness Methods (FAMs): A Pilot Study [PDF]

, 2014
Purpose: Difficult clinical signs such as confusing cervical mucus or erratic basal body temperature can make the use of fertility awareness methods (FAMs) difficult in some cases.
Burban, Ula, Dalzell, Catherine, Fehring, Richard, Kyrillos, Edmond, Letva, Rene, McLaren, Robin, Tanguay, Elizabeth   +6 more
core   +1 more source