Results 91 to 100 of about 11,867 (232)

Hormonal and Allosteric Regulation of the Luteinizing Hormone/Chorionic Gonadotropin Receptor

Frontiers in Bioscience-Landmark
Luteinizing hormone (LH) and human chorionic gonadotropin (CG), like follicle-stimulating hormone, are the most important regulators of the reproductive system.
Alexander O. Shpakov
doaj   +1 more source

Genomic technologies and the diagnosis of 46, XY differences of sex development

Andrology, Volume 13, Issue 5, Page 1025-1043, July 2025.
Abstract Differences/disorders of sex development can be caused by disruptions to the molecular and cellular mechanisms that control development and sex determination of the reproductive organs with 1:100 live births affected. Multiple genes are associated with 46, XY differences/disorders of sex development that can cause varying clinical phenotypes ...
Firman Idris, Andrew H. Sinclair, Katie L. Ayers   +2 more
wiley   +1 more source

Systems Genetics Reveals the Functional Context of PCOS Loci and Identifies Genetic and Molecular Mechanisms of Disease Heterogeneity.

PLoS Genetics, 2015
Genome wide association studies (GWAS) have revealed 11 independent risk loci for polycystic ovary syndrome (PCOS), a common disorder in young women characterized by androgen excess and oligomenorrhea.
Michelle R Jones, Meredith A Brower, Ning Xu, Jinrui Cui, Emebet Mengesha, Yii-Der I Chen, Kent D Taylor, Ricardo Azziz, Mark O Goodarzi   +8 more
doaj   +1 more source

Molecular regulation of LHCGR expression by miR-122 during follicle growth in the rat ovary [PDF]

Molecular and Cellular Endocrinology, 2017
We have previously reported that LHCGR expression in the ovary is regulated through a post-transcriptional mechanism involving an mRNA binding protein designated as LRBP, which is regulated, at least in part, by a non-coding RNA, miR-122. Our present study examined the regulatory role of miR-122 in FSH-induced LHCGR expression during follicle ...
Thippeswamy Gulappa, Bindu Menon, K. M. J. Menon   +2 more
openaire   +3 more sources

The Pathogenic TSH β-Subunit Variant C105Vfs114X Causes a Modified Signaling Profile at TSHR [PDF]

, 2019
1) Background: Central congenital hypothyroidism (CCH) is a rare endocrine disorder that can be caused by mutations in the β-subunit of thyrotropin (TSHB).
Biebermann, Heike, Grüters-Kieslich, Annette, Kalveram, Laura, Kleinau, Gunnar, Rivero-Müller, Adolfo, Scheerer, Patrick, Szymańska, Kamila   +6 more
core   +1 more source

Loss of Cx43 in Murine Sertoli Cells Leads to Altered Prepubertal Sertoli Cell Maturation and Impairment of the Mitosis-Meiosis Switch. [PDF]

, 2020
Male factor infertility is a problem in today's society but many underlying causes are still unknown. The generation of a conditional Sertoli cell (SC)-specific connexin 43 (Cx43) knockout mouse line (SCCx43KO) has provided a translational model ...
Behr, Rüdiger, Brehm, Ralph HJ, Distl, Ottmar, Hilbold, Erika, Hoedemaker, Martina, Jung, Klaus, Langeheine, Marion, Metzger, Julia, Rajkovic, Aleksandar, Rode, Kristina, Wilkening, Sandra   +10 more
core   +1 more source

A genome-wide association study identified a novel genetic loci STON1-GTF2A1L/LHCGR/FSHR for bilaterality of neovascular age-related macular degeneration

Scientific Reports, 2017
Bilateral neovascular age-related macular degeneration (AMD) causes much more handicaps for patients than unilateral neovascular AMD. Although several AMD-susceptibility genes have been evaluated for their associations to bilaterality, genome-wide ...
Kyoko Kawashima-Kumagai, Kenji Yamashiro, Munemitsu Yoshikawa, Masahiro Miyake, Gemmy Cheung Chui Ming, Qiao Fan, Jia Yu Koh, Masaaki Saito, Masako Sugahara-Kuroda, Maho Oishi, Yumiko Akagi-Kurashige, Isao Nakata, Hideo Nakanishi, Norimoto Gotoh, Akio Oishi, Hiroshi Tamura, Sotaro Ooto, Akitaka Tsujikawa, Yasuo Kurimoto, Tetsuju Sekiryu, Fumihiko Matsuda, Chiea-Chuen Khor, Ching-Yu Cheng, Tien Yin Wong, Nagahisa Yoshimura   +24 more
doaj   +1 more source

Hyperprolactinemia induced by hCG leads to metabolic disturbances in female mice [PDF]

, 2016
The metabolic syndrome is a growing epidemic; it increases the risk for diabetes, cardiovascular disease, fatty liver, and several cancers. Several reports have indicated a link between hormonal imbalances and insulin resistance or obesity.
Bonaventura, Maria Marta, Calandra, Ricardo Saul, Huhtaniemi, Ilpo T., Lux, Victoria Adela R., Poutanen, Matti, Ratner, Laura Daniela, Rulli, Susana Beatriz, Stevens, Guillermina   +7 more
core   +1 more source

Vernal growth of vocal control nucleus Area X, but not HVC, precedes gonadal recrudescence in wild black‐capped chickadees (Poecile atricapillus)

Journal of Neuroendocrinology, Volume 37, Issue 6, June 2025.
According to the longstanding model of vernal recrudescence of the songbird vocal control system, upregulation of the hypothalamic‐pituitary‐gonadal axis, and specifically testosterone (T), promotes growth first of HVC, and then Area X. In this study, we show that in black‐capped chickadees, Area X is already fully recrudesced ahead of HPG axis ...
Broderick M. B. Parks, Kyle McVea, Leslie S. Phillmore   +2 more
wiley   +1 more source

Spatiotemporal expression pattern of miR-205, miR-26a-5p, miR-17-5p, let-7b-5p, and their target genes during different stages of corpus luteum in Egyptian buffaloes

Journal of Genetic Engineering and Biotechnology, 2022
Background No doubt that the corpus luteum (CL) plays a vital role in the regulation of female cyclicity in mammals. The scenarios among microRNAs (miRNAs) and their target genes and steroid hormones {estradiol (E2) and progesterone (P4)} are required ...
Sally Ibrahim, Mohamed O. Taqi, A. S. A. Sosa, Al-Shimaa Al-H. H. El-Naby, Karima Gh. M. Mahmoud, Hassan R. H. Darwish, Amal R. Abd El Hameed, M. F. Nawito   +7 more
doaj   +1 more source