Results 71 to 80 of about 11,587 (188)

Differences in signal activation by LH and hCG are mediated by the LH/CG receptor`s extracellular hinge region

Frontiers in Endocrinology, 2015
The human lutropin/choriogonadotropin receptor (LHCGR) can be activated by binding two slightly different gonadotropic glycoprotein hormones, choriogonadotropin (CG) - secreted by the placenta, and lutropin (LH) - produced by the pituitary.
Paul eGrzesik, Annika eKreuchwig, Claudia eRutz, Jens eFurkert, Burkhard eWiesner, Ralf eSchülein, Gunnar eKleinau, Joerg eGromoll, Gerd eKrause   +8 more
doaj   +1 more source

Carrier screening in the reproductive setting—Are there medical implications for the heterozygote?—A guide for clinicians

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld, Nicole Kasatkin, Bi Liu Yu, Milen Velinov, Justin S. Brandt, Elena Ashkinadze   +5 more
wiley   +1 more source

LHCGR expression in the bovine CL.

, 2013
Relative levels of LHCGR mRNA in bovine CL throughout the estrous cycle (n=4).
Shin Yoshioka (502604), Ryosuke Sakumoto (502606), Hironori Abe (502605), Kiyoshi Okuda (502607)   +3 more
core   +1 more source

Systems Genetics Reveals the Functional Context of PCOS Loci and Identifies Genetic and Molecular Mechanisms of Disease Heterogeneity.

PLoS Genetics, 2015
Genome wide association studies (GWAS) have revealed 11 independent risk loci for polycystic ovary syndrome (PCOS), a common disorder in young women characterized by androgen excess and oligomenorrhea.
Michelle R Jones, Meredith A Brower, Ning Xu, Jinrui Cui, Emebet Mengesha, Yii-Der I Chen, Kent D Taylor, Ricardo Azziz, Mark O Goodarzi   +8 more
doaj   +1 more source

Luteinizing hormone receptor knockout mouse: What has it taught us?

Andrology, Volume 14, Issue 4, Page 1017-1028, May 2026.
Abstract Luteinizing hormone (LH), along with its agonist choriongonadotropin (hCG) in humans, is the key hormone responsible for the tropic regulation of the gonadal function. LH and hCG act through their cognate receptor, the luteinizing hormone/choriongonadotropin receptor (LHCGR; more appropriately LHR in rodents lacking CG), located in the testis ...
Ilpo T. Huhtaniemi
wiley   +1 more source

Cellular localization of LHCGR and morphological changes of hGLC under continuous exposure to hLH 500 (pM) by confocal microscopy.

, 2012
a. Unstimulated cells (control) after 1 hour. b. hLH-treated cells after 1 hour. c. Unstimulated cells after 15 hours. d. LHCGR sequestration from cell surface in hLH-treated hGLC, after 15 hours. e. Unstimulated cells after 24 hours. f. Cell-rounding in
Antonio La Marca (130452), Manuela Simoni (45413), Daniela Tagliasacchi (130455), Elisa Pignatti (130458), Livio Casarini (130441), Monica Lispi (130444), Salvatore Longobardi (130447), Fabiola Milosa (130449)   +7 more
core   +1 more source

Hormonal and Allosteric Regulation of the Luteinizing Hormone/Chorionic Gonadotropin Receptor

Frontiers in Bioscience-Landmark
Luteinizing hormone (LH) and human chorionic gonadotropin (CG), like follicle-stimulating hormone, are the most important regulators of the reproductive system.
Alexander O. Shpakov
doaj   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, Volume 14, Issue 4, Page 978-991, May 2026.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Natural antisense LHCGR could make sense of hypogonadism, male-limited precocious puberty and pre-eclampsia

, 2005
The pleiotropic effects of human chorionic gonadotrophin (hCG), the key regulator of human pregnancy, are dependent upon cell surface expression of its functional cognate receptor LHCGR in the placental trophoblasts, corpus luteum, uterus, vascular ...
Chambers, A E, Banerjee, S
core   +1 more source

ASSOCIATION OF NUMBER OF ARTIFICIAL INSEMINATIONS PER PREGNANCY IN HOLSTEIN DAIRY COWS WITH POLYMORPHISM IN LUTEINIZING HORMONE RECEPTOR AND FOLLICLE STIMULATING HORMONE RECEPTOR GENES

Slovenian Veterinary Research, 2017
Failure to become pregnant is the primary reason for a dairy cow to be culled from the production herd. A cow that is cycling normally, with no reproductive abnormalities, but has failed to conceive after at least three successive inseminations may ...
Korhan Arslan, Bilal Akyüz, Aytaç Akçay, Esma Gamze İlgar, Hasan Ceyhun Macun, Mehmet Ulaş Çınar   +5 more
doaj   +1 more source