Results 61 to 70 of about 11,587 (188)

A new variant in signal peptide of the human luteinizing hormone receptor (LHCGR) affects receptor biogenesis causing leydig cell hypoplasia [PDF]

, 2015
The human luteinizing hormone/chorionic gonadotropin receptor (LHCGR) plays a fundamental role in male and female reproduction. In males, loss-of-function mutations in LHCGR have been associated with distinct degrees of impairment in pre- and postnatal ...
I. Bassi, R. Minari, A. Vottero, S. Bernasconi, V. Vezzoli, M. Bonomi, G. Kleinau, P. Duminuco, L. Persani, R. Schülein   +9 more
core   +1 more source

Advances in the Study of Endometrial Receptivity and Glucose Metabolism Mechanisms in Insulin Resistance

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 4, July 2026.
This article systematically reviews how insulin resistance (IR) disrupts endometrial receptivity by interfering with glucose metabolism mechanisms, ultimately leading to infertility in patients with Polycystic Ovary Syndrome (PCOS). ABSTRACT Introduction Insulin resistance (IR) is one of the important pathologic bases of polycystic ovary syndrome (PCOS)
Si‐yan Huang, Shao‐rong Chen, Wei‐hong Chen, Ling‐tao Zheng, Jing Xu, Yan‐Chuan Shi, Shu Lin, Qi‐rong Shi   +7 more
wiley   +1 more source

GATA2-LHCGR regulatory network promotes follicle development by enhancing granulosa cell proliferation and ovarian steroidogenesis in Wanxi white geese

Scientific Reports
Low egg production in Wanxi white geese limits their commercial viability. This study investigates the role of luteinizing hormone/choriogonadotropin receptor (LHCGR) in regulating granulosa cell function and egg production.
Jinzhou Peng, Hailiang Yu, Xiaowei Yang, Weihuang Lin, Xiao Wang, Qiming Xu, Xingyong Chen   +6 more
doaj   +1 more source

LHCGR inactivating variants: single center experience and systematic review of phenotype-genotype of 46,XY and 46,XX patients

Endocrine Connections
Background: The data on Leydig cell hypoplasia (LCH) resulting from biallelic Luteinizing hormone/chorionic gonadotropin receptor (LHCGR) inactivating variants is limited to case series.
Rohit Barnabas, Swati Jadhav, Anurag Ranjan Lila, Sirisha Kusuma Boddu, Saba Samad Memon, Sneha Arya, Samiksha Chandrashekhar Hegishte, Manjiri Karlekar, Virendra A Patil, Vijaya Sarathi, Nalini S Shah, Tushar Bandgar   +11 more
doaj   +1 more source

Cryptorchidism: Novel genetic insights into CCDC149 mutations

Andrology, Volume 14, Issue 5, Page 1155-1163, July 2026.
Abstract Background Cryptorchidism, characterized by the failure of one or both testes to descend into the scrotum, is a common congenital condition that can lead to infertility and increased risk of testicular cancer. CCDC149, a coiled‐coil domain‐containing protein, has been implicated in various developmental processes, but its role in the male ...
Shengrong Du, Shan Xu, Lei Yang, Yan Ye, Yuhan Wu, Ziyun Xiao, Xiuqing Dong, Wenliang Yao, Hua Li   +8 more
wiley   +1 more source

Pubertal development and hypothalamic–pituitary–gonadal axis are altered in male mice lacking Mecp2

Journal of Neuroendocrinology, Volume 38, Issue 7, July 2026.
Abstract Mutations in the MECP2 gene, encoding the epigenetic reader Methyl‐CpG binding protein 2, are the main cause of Rett syndrome, a rare neurodevelopmental disorder. Besides severe symptoms such as profound intellectual disability, loss of speech and motor skills, and epilepsy, loss of function of MECP2 has been associated with pubertal ...
Ana Martín‐Sánchez, Daniela Jiménez‐Díaz, Rafael Esteve‐Pérez, Alexandru Vasile‐Tudorache, Jordan E. Read, Sasha R. Howard, Carmen Agustín‐Pavón   +6 more
wiley   +1 more source

A delayed ovulation of Progestin-Primed Ovarian Stimulation (PPOS) by down-regulating the LHCGR/PGR pathway

iScience, 2022
Abstract PPOS as a new clinic ovulation stimulation protocol, its role in ovulation and regulatory mechanism is not clear. The clinical PPOS protocol was simulated in mice, and it had a delayed ovulation than the control group at 12.5 hours after hCG trigger.
Yating Xie, Wenya Guo, Xi Shen, Weina Yu, Yanping Kuang, Qiuju Chen, Hui Long, Qifeng Lyu, Li Wang   +8 more
openaire   +3 more sources

Lactate metabolism and lactylation in female reproductive diseases: From metabolic rewiring to biomarkers and translational therapeutics

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
1. Lactate‐derived histone lactylation links glycolytic reprogramming to epigenetic regulation in female reproductive diseases. 2. In endometriosis, lactylation may promote inflammatory remodelling, immune dysregulation and ferroptosis resistance. 3. In PCOS, lactylation connects metabolic disturbance to granulosa‐cell dysfunction and hyperandrogenism.
Jiajun Qiao, Yue Xiao, Yi Cheng, Weihai Xu, Jing Shu, Shishi Li   +5 more
wiley   +1 more source

MD files (psf, pdb, and toppar) for the trajectories of the glycoprotein receptors FSHR and LHCGR.

, 2023
<p>PSF and PDB files for trajectories on FSHR and LHCGR in SDPC lipids. Top and par parameters for charmm36m included.</p><p>PDB files and trr files include only backbone atoms. All frames were fitted to the to the transmembrane domains.
Eduardo, Jardon-valadez
core   +1 more source

Widespread Distribution of Luteinizing Hormone/Choriogonadotropin Receptor in Human Juvenile Angiofibroma: Implications for a Sex-Specific Nasal Tumor

Cells
Juvenile angiofibroma (JA) is a rare, sex-specific, and highly vascularized nasal tumor that almost exclusively affects male adolescents, but its etiology has been controversial.
Silke Wemmert, Martina Pyrski, Lukas Pillong, Maximilian Linxweiler, Frank Zufall, Trese Leinders-Zufall, Bernhard Schick   +6 more
doaj   +1 more source