Results 51 to 60 of about 11,587 (188)

Polymorphism in the Alternative Donor Site of the Cryptic Exon of LHCGR: Functional Consequences and Associations with Testosterone Level

, 2017
Selective splicing is a feature of luteinizing hormone receptor (LHCGR). A cryptic exon (LHCGR-exon 6A) was found to be derived from alternative splicing in intron 6 of the LHCGR gene, which including two transcripts LHCGR-exon 6A-long and LHCGR-exon 6A ...
Yanping Kuang, Wenjiao Zhu, Shuangxia Zhao, Jie Qiao, Tong Cheng, Mengxia Fan, Jiqiang Si, Qifeng Lyu, Huaidong Song, Weiran Chai, Bing Han, Jiajun Wu, Ying Yang, Hui Zhu, Wei Liu   +14 more
core   +1 more source

Pyroptotic Macrophage Extracellular Vesicles Drive miR‐103a‐3p Mediated Mitochondrial Dysfunction in Granulosa Cells in Diminished Ovarian Reserve

Aging Cell, Volume 25, Issue 11, November 2026.
Pyroptotic macrophages release extracellular vesicles enriched in miR‐103a‐3p. These EVs are taken up by granulosa cells, where miR‐103a‐3p targets MFN2 and BCL2L13, disrupting mitochondrial homeostasis and increasing oxidative stress and apoptosis. This EV‐mediated signaling axis contributes to diminished ovarian reserve and represents a potential ...
Wenhan Ju, Xin Xin, Yanli Xiao, Liwen Song, Jinfu Zhang, Shan Xiang   +5 more
wiley   +1 more source

Role of Single Nucleotide Variants in FSHR, GNRHR, ESR2 and LHCGR Genes in Adolescents with Polycystic Ovary Syndrome

Diagnostics, 2021
Background: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women, affecting up to 16.6% of reproductive-age women. PCOS symptoms in adolescents comprise oligomenorrhoea/amenorrhoea and biochemical and/or clinical hyperandrogenism ...
Lasma Lidaka, Laine Bekere, Adele Rota, Jekaterina Isakova, Gunta Lazdane, Anda Kivite-Urtane, Iveta Dzivite-Krisane, Inga Kempa, Zane Dobele, Linda Gailite   +9 more
doaj   +1 more source

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, Volume 14, Issue 8, Page 2401-2418, November 2026.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source

The Luteinizing Hormone-Testosterone Pathway Regulates Mouse Spermatogonial Stem Cell Self-Renewal by Suppressing WNT5A Expression in Sertoli Cells

Stem Cell Reports, 2016
Spermatogenesis originates from self-renewal of spermatogonial stem cells (SSCs). Previous studies have reported conflicting roles of gonadotropic pituitary hormones in SSC self-renewal.
Takashi Tanaka, Mito Kanatsu-Shinohara, Zhenmin Lei, C.V. Rao, Takashi Shinohara   +4 more
doaj   +1 more source

Recent advances in polyendocrine metabolic ovarian syndrome, formerly polycystic ovary syndrome, with emphasis on endocrine and metabolic dysfunction and cardiovascular risk

Journal of Internal Medicine, Volume 300, Issue 5, Page 590-609, November 2026.
Abstract Polyendocrine metabolic ovarian syndrome (PMOS), previously known as polycystic ovary syndrome, affects 10%–13% of women of reproductive age and remains underdiagnosed despite its substantial health burden. The introduction of the new PMOS nomenclature in 2026 reflects a fundamental shift in understanding the condition as a lifelong endocrine ...
Maria Forslund, Johanna Melin, Anju E. Joham, Terhi T. Piltonen, D. Aled Rees, Helena J. Teede   +5 more
wiley   +1 more source

Long-Term Treatment With Letrozole in a Boy With Familial Male-Limited Precocious Puberty

Frontiers in Endocrinology, 2022
BackgroundThe long-term follow-up in children with familial male-limited precocious puberty (FMPP) who were treated with letrozole, triptorelin, and spironolactone is limited, especially considering the efficiency and safety.ObjectiveWe describe the ...
Xin Yuan, Ruimin Chen, Ying Zhang, Xiaohong Yang, Xiangquan Lin   +4 more
doaj   +1 more source

Potentially Toxic Elements and Male Reproductive Toxicity: Mechanisms, Implications, and Protective Strategies: A Narrative Review

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
Potentially toxic elements impair male reproductive function through oxidative stress, DNA damage, mitochondrial dysfunction, inflammation, endocrine disruption and epigenetic alterations. Antioxidants, phytochemicals, chelating agents and healthy lifestyle interventions may help mitigate testicular toxicity and preserve fertility.
Sakshi Yadav, Placheril J John
wiley   +1 more source

Precocious Puberty in a Boy With Bilateral Leydig Cell Tumors due to a Somatic Gain-of-Function LHCGR Variant

, 2022
CONTEXT: Autosomal dominant and rarely de novo gain-of-function variants in the LHCGR gene are associated with precocious male puberty, while somatic LHCGR variants have been found in isolated Leydig cell adenomas and Leydig cell hyperplasia.
Merke, Deborah P, Boyce, Alison M, Chelsi Flippo, Daniel Casella, Kolli, Vipula, Stephen M Hewitt, Joseph Devaney, Devaney, Joseph, Mallappa, Ashwini, Michael T Collins, Collins, Michael T, Emmanuèle Délot, Thomas Kolon, Casella, Daniel, White, Perrin C, Andrew, Melissa, Vipula Kolli, Tricia Bhatti, Flippo, Chelsi, Deborah P Merke, Melissa Andrew, Andrew Dauber, Bhatti, Tricia, Alison M Boyce, Délot, Emmanuèle, Perrin C White, Hewitt, Stephen M, Seth Berger, Dauber, Andrew, Kolon, Thomas, Ashwini Mallappa, Berger, Seth   +31 more
core   +1 more source

Novel Compound Heterozygous Variants in the LHCGR Gene in a Genetically Male Patient with Female External Genitalia

JCRPE, 2019
The LHCGR gene encodes a G-protein coupled receptor that plays a pivotal role in sexual differentiation in males, ovarian development in females and in fertility via its interaction with luteinizing hormone and chorionic gonadotropin.
Mei Yan, Julaiti Dilihuma, Yanfei Luo, Baoerhan Reyilanmu, Yiping Shen, Maimaiti Mireguli   +5 more
doaj   +1 more source