Results 31 to 40 of about 11,587 (188)

Diagnosis and treatment of familial male precocious puberty caused by LHCGR gene mutation: two case reports and literature review [PDF]

Zhenduanxue lilun yu shijian, 2022
Objective: To report the clinical features, gene detection results and treatment results of two patients with familial male limited precocious puberty(FMPP). Methods: Detailed medical history collection and physical examination were carried out in 2 FMPP
HE Qinyu, WANG Wei, CHEN Lifen, ZHANG Xuelei, DONG Zhiya
doaj   +1 more source

Significance of LHCGR polymorphisms in polycystic ovary syndrome: an association study

Scientific Reports, 2023
AbstractThis study was conducted to analyze the association of Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR) gene rs4953616 and rs7371084 polymorphisms with the risk of polycystic ovary syndrome (PCOS) in Punjab, India. A total of 823 women (443 PCOS cases and 380 healthy controls) were enrolled in the present study.
Sukhjashanpreet Singh, Mandeep Kaur, Archana Beri, Anupam Kaur   +3 more
openaire   +3 more sources

Pregnancy-induced Cushing syndrome mediated by overexpressing <i>LHCGR</i> with bilateral micronodular adrenocortical disease. [PDF]

JCEM Case Rep
Abstract Pregnancy-induced Cushing syndrome (PICS), in which the onset of cortisol excess occurs during pregnancy with spontaneous remission postpartum, is a rare entity with serious maternal and fetal consequences. We describe the case of a 31-year-old woman who presented with pre-eclampsia at 24 weeks gestational age and florid ...
Gandhi C, McNab T, Khurana R, Tateno T, McMullen T, Chik C.   +5 more
europepmc   +3 more sources

Novel functions of the luteinizing hormone/chorionic gonadotropin receptor in prostate cancer cells and patients.

PLoS ONE, 2020
Prostate cancer (PCa) cells become castrate-resistant after initial tumor regression following castration-based lowering of testosterone (T). De-novo intra-tumoral steroid synthesis is a suggested biological mechanism of castration resistant PCa, but the
Hein Vincent Stroomberg, Anne Jørgensen, Klaus Brasso, John Erik Nielsen, Anders Juul, Hanne Frederiksen, Martin Blomberg Jensen, Martin Andreas Røder   +7 more
doaj   +1 more source

Influence of VEGFR and LHCGR on endometrial adenocarcinoma

Oncology Letters, 2016
Endometrial adenocarcinoma is a common gynecological malignancy that is usually treated by surgical resection followed by radiation. However, the frequency of remote metastasis is high. The present study aimed to investigate whether patients with endometrial adenocarcinoma exhibited a positive response to treatment with a gonadotropin-releasing hormone
Alexandra C, Kölbl, Amelie E, Birk, Christina, Kuhn, Udo, Jeschke, Ulrich, Andergassen   +4 more
openaire   +3 more sources

The utility of circulating LHCGR as a predictor of Down's syndrome in early pregnancy [PDF]

BMC Pregnancy and Childbirth, 2014
Previous studies showed that soluble LHCGR/hCG-sLHCGR concentrations in serum or plasma combined with PAPP-A and free βhCG significantly increased the sensitivity of Down's syndrome screen at early pregnancy without altering the false positive rate. The goal of the present study was to further examine the role of sLHCGR forms as combinatorial markers ...
Chambers, Anne E, Mills, Walter E, Mercadé, Imma, Crovetto, Francesca, Crispi, Fatima, Bodi, Laia Rodriguez-Revenga, Pugia, Michael, Mira, Aurea, Lasalvia, Luis, Banerjee, Subhasis, Casals, Elena, Gratacos, Eduard   +11 more
openaire   +2 more sources

Genetic models for the study of luteinizing hormone receptor function

Frontiers in Endocrinology, 2015
The luteinizing hormone/chorionic gonadotropin receptor, LHCGR, is essential for fertility in men and women. LHCGR binds luteinizing hormone (LH) as well as the highly homologous chorionic gonadotropin (CG).
Prema eNarayan
doaj   +1 more source

46 XY undervirulized male DSD: Reporting a patient with prenatally diagnosed disorder/difference of sex development (DSD) with heterozygous LHCGR mutations

Urology Case Reports, 2022
Leydig cell hypoplasia is a rare autosomal recessive condition caused by mutations in luteinizing hormone/chorionic gonadotropin receptor (LHCGR) genes in which 46, XY patients demonstrate a wide spectrum of disorders/differences of sex development (DSD)
Kiarad Fendereski, John Carey, Kathleen Timme, Katherine Hayes, Jessica Robnett, Anthony Schaeffer   +5 more
doaj   +1 more source

Pregnancy and Live Birth In Women With Pathogenic LHCGR Variants Using Their Own Oocytes [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2019
Abstract Context The LH/chorionic gonadotropin receptor (LHCGR) is mainly expressed in gonads and plays important roles in estradiol production, ovulation, and luteal formation. Women with pathogenic LHCGR variants suffer from infertility, and successful fertility treatments for such women have never ...
Xuefeng Lu, Zheng Yan, Renfei Cai, Shuzin Khor, Ling Wu, Lihua Sun, Yun Wang, Yao Xu, Hui Tian, Qiuju Chen, Jie Qiao, Bing Li, Biaobang Chen, Yu Cao, Qifeng Lyu, Lei Wang, Yanping Kuang   +16 more
openaire   +2 more sources

Acute hypoxia induced dysregulation of clock-controlled ovary functions

Frontiers in Physiology, 2022
High altitudes or exposure to hypoxia leads to female reproductive disorders. Circadian clocks are intrinsic time-tracking systems that enable organisms to adapt to the Earth’s 24-h light/dark cycle, which can be entrained by other environmental stimuli ...
Mengnan Ding, Yarong Lu, Yarong Lu, Xin Huang, Chen Xing, Shaojun Hou, Shaojun Hou, Shaojun Hou, Dongxue Wang, Dongxue Wang, Yifan Zhang, Wei Wang, Wei Wang, Chongchong Zhang, Chongchong Zhang, Min Zhang, Min Zhang, Fanfei Meng, Kun Liu, Guangchao Liu, Jincheng Zhao, Lun Song, Lun Song, Lun Song, Lun Song   +24 more
doaj   +1 more source