Quantitative ELISAs for serum soluble LHCGR and hCG-LHCGR complex: potential diagnostics in first trimester pregnancy screening for stillbirth, Down’s syndrome, preterm delivery and preeclampsia [PDF]
Reproductive Biology and Endocrinology, 2012 Background Soluble LH/hCG receptor (sLHCGR) released from placental explants and transfected cells can be detected in sera from pregnant women. To determine whether sLHCGR has diagnostic potential, quantitative ELISAs were developed and tested to examine
Chambers Anne E +7 more
doaj +6 more sources
LHCGR (luteinizing hormone/choriogonadotropin receptor) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on LHCGR (luteinizing hormone/choriogonadotropin receptor), with data on DNA, on the protein encoded, and where the gene is implicated.
Tsai-Morris, CH, Dufau, ML
core +6 more sources
Microvesicle-mediated release of soluble LH/hCG receptor (LHCGR) from transfected cells and placenta explants [PDF]
Reproductive Biology and Endocrinology, 2011 Placental hCG and pitutary LH transduce signals in target tissues through a common receptor (LHCGR). We demonstrate that recombinant LHCGR proteins which include the hormone-binding domain are secreted from transfected cells and that natural LHCGR is ...
Randeva Harpal +3 more
doaj +2 more sources
Luteinizing Hormone and GATA4 Action in the Adrenocortical Tumorigenesis of Gonadectomized Female Mice [PDF]
Cellular Physiology and Biochemistry, 2017 Background/Aims: Physiological role of luteinizing hormone (LH) and its receptor (LHCGR) in adrenal remains unknown. In inhibin-α/Simian Virus 40 T antigen (SV40Tag) (inhα/Tag) mice, gonadectomy-induced (OVX) elevated LH triggers the growth of ...
Milena Doroszko +10 more
doaj +5 more sources
A major QTL at the LHCGR/FSHR locus for multiple birth in Holstein cattle [PDF]
Genetics Selection Evolution, 2021 Abstract Background Twin and multiple births are rare in cattle and have a negative impact on the performance and health of cows and calves. Therefore, selection against multiple birth would be desirable in dairy cattle breeds such as Holstein.
Widmer, Sarah +5 more
openaire +6 more sources
ВАРИАНТ RS7579411 ГЕНА LHCGR АССОЦИИРОВАН С РАЗВИТИЕМ ГИПЕРПЛАЗИИ ЭНДОМЕТРИЯ [PDF]
Генетика, 2022 Изучены ассоциации однонуклеотидного полиморфизма гена LHCGR с формированием гиперплазии эндометрия у населения ...
Ефремова, O. А. +4 more
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A link between high serum levels of human chorionic gonadotrophin and chorionic expression of its mature functional receptor (LHCGR) in Down's syndrome pregnancies [PDF]
Reproductive Biology and Endocrinology, 2005 Human chorionic gonadotrophin (hCG) is released from placental trophoblasts and is involved in establishing pregnancy by maintaining progesterone secretion from the corpus luteum. Serum hCG is detected in the maternal circulation within the first 2–3 wks
Spencer Kevin +7 more
doaj +7 more sources
Inherited mutation of the luteinizing hormone/choriogonadotropin receptor (LHCGR) in empty follicle syndrome [PDF]
Fertility and Sterility, 2011 To test by genomic analysis whether empty follicle syndrome (EFS) in a family with two affected sisters has a genetic basis.Whole-exome sequencing in the context of clinical genetics.University hospital.Two women (36 and 32 years old at the time of the study) with EFS.Genetic counseling based on autosomal recessive inheritance.Discovery of a mutation ...
Kemal O, Yariz +7 more
openaire +3 more sources
Lhcgr Expression in Granulosa Cells: Roles for PKA-Phosphorylated β-Catenin, TCF3, and FOXO1
Molecular Endocrinology, 2013 Ovarian follicles lacking FSH or FSH receptors fail to progress to a preovulatory stage, resulting in infertility. One hallmark of the preovulatory follicle is the presence of luteinizing hormone/choriogonadotropin receptors (LHCGR) on granulosa cells (GCs). However, the mechanisms by which FSH induces Lhcgr gene expression are poorly understood.
Law, Nathan C +4 more
openaire +5 more sources
A genome-wide association study identified a novel genetic loci STON1-GTF2A1L/LHCGR/FSHR for bilaterality of neovascular age-related macular degeneration [PDF]
Scientific Reports, 2017 Bilateral neovascular age-related macular degeneration (AMD) causes much more handicaps for patients than unilateral neovascular AMD. Although several AMD-susceptibility genes have been evaluated for their associations to bilaterality, genome-wide ...
Kyoko Kawashima-Kumagai +24 more
doaj +2 more sources