LHCGR phamacodynamic effects during follicular maturation [PDF]
Frontiers in EndocrinologyLuteinizing hormone (LH) and human chorionic gonadotropin (hCG) are glycoprotein hormones that regulate human reproduction. Although they bind the same G protein-coupled membrane receptor (LHCGR) and have high percentage of structural identity, recent ...
Carmela Perri +4 more
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Frontiers in Endocrinology, 2022 An association between endometriosis and luteinized unruptured follicle syndrome (LUFs) has long been identified. Although inactivating mutation of luteinizing hormone/choriogonadotropin receptor (LHGCR) results in LUFs, whether LHCGR contributes to ...
Zhidan Hong, Yuming Cao
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A case of micropenis caused by compound heterozygote mutations in luteinizing hormone/choriogonadotropin receptor (LHCGR) [PDF]
Jichu yixue yu linchuang, 2022 Objective To investigate the pathogenic gene mutations and clinical characteristics in a patient with compound heterozygote gene mutations in luteinizing hormone/choriogonadotropin receptor (LHCGR) gene.
YANG Yu-fan, ZHAO Ya-ling, WANG Xi, NIE Min, WU Xue-yan, MAO Jiang-feng
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The G-protein coupled estrogen receptor (GPER/GPR30) is a gonadotropin receptor dependent positive prognosticator in ovarian carcinoma patients. [PDF]
PLoS ONE, 2013 Follicle stimulating hormone receptor (FSHR) and luteinizing hormone receptor (LHCGR) were demonstrated to impact upon survival of patients suffering from epithelial ovarian cancer (EOC).
Sabine Heublein +6 more
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Genetic variants (Lhcgr W495X/+) and environmental toxicants (DEHP) synergistically induce DSD by interfering with steroidogenic gene expression [PDF]
Biology of Sex DifferencesBackground Emerging evidence suggests that genetic variants and environmental toxicants may synergistically contribute to DSD. To test this hypothesis, we employed Lhcgr W495X/+ (luteinizing hormone/chorionic gonadotropin receptor) male mice subjected to
Xie Qigen +5 more
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Акушерство, гинекология и репродукция, 2023 Introduction. Infertility is a highly fatal reproductive system disorder that affects the ability of a couple to reproduce. Over the past decades, a drastic uplift has been recorded in infertility cases among males ranging from 20 to 70 % indicating ...
N. A. Oohayyed +5 more
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Open Veterinary Journal, 2023 Background: Genotyping offers a promising avenue for identifying the healthy reproductive system in cows. The healthy reproductive system in cows is determined by measuring the level of ovulation and by identifying the type polymorphism of specific ...
Yktiyar Sarybayev +4 more
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Evidence for gating roles of protein kinase A and protein kinase C in estradiol-induced luteinizing hormone receptor (lhcgr) expression in zebrafish ovarian follicle cells. [PDF]
PLoS ONE, 2013 Estradiol (E2) stimulates luteinizing hormone receptor (lhcgr) expression in zebrafish follicle cells via nuclear estrogen receptors (nERs) that are likely expressed on the membrane, and lhcgr responds to E2 in a biphasic manner during 24-h treatment ...
Ka-Cheuk Liu, Wei Ge
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Indian Journal of Endocrinology and Metabolism, 2021 Background: Polycystic ovarian syndrome (PCOS) is typically characterized by a spectrum of manifestations that include menstrual irregularities, anovulation, cysts, hyperandrogenic features like hirsutism, acne, alopecia, and various metabolic ...
Balaji Ramanathan +2 more
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Mutations in a novel, cryptic exon of the luteinizing hormone/chorionic gonadotropin receptor gene cause male pseudohermaphroditism. [PDF]
PLoS Medicine, 2008 Male pseudohermaphroditism, or Leydig cell hypoplasia (LCH), is an autosomal recessive disorder in individuals with a 46,XY karyotype, characterized by a predominantly female phenotype, a blind-ending vagina, absence of breast development, primary ...
Nina Kossack +4 more
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