Results 21 to 30 of about 11,587 (188)

Testotoxicosis: Report of Two Cases, One with a Novel Mutation in LHCGR Gene

Journal of Clinical Research in Pediatric Endocrinology, 2015
Testotoxicosis is a rare disorder which presents as isosexual peripheral precocious puberty in males. Despite the pattern of autosomal dominant inheritance, sporadic cases also may occur. Due to activating mutation in luteinizing hormone (LH))/choriogonadotropin receptor (LHCGR) gene, early virilization and advancement in bone age are common with ...
Özcabı, Bahar, Tahmiscioğlu Bucak, Feride, Ceylaner, Serdar, Özcan, Rahşan, Büyükünal, Cenk, Ercan, Oya, Tüysüz, Beyhan, Evliyaoğlu, Olcay   +7 more
core   +5 more sources

LHCGR Gene Analysis in Girls with Non-Classic Central Precocious Puberty

Experimental and Clinical Endocrinology & Diabetes, 2018
Abstract Background Luteinizing hormone (LH) is a useful parameter in diagnosing precocious puberty. The pubertal response of serum LH to a GnRH stimulation test is varied, and clinical symptoms of precocious puberty are sometimes disproportionate with serum LH concentrations.
Hwal Rim, Jeong, Hae Sang, Lee, Jin Soon, Hwang   +2 more
core   +4 more sources

Assessment of Testicular Lhcgr mRNA Expression Correlated with Testis and Seminal Vesicle Activities in the Libyan jird (Meriones libycus, Rodentia: Muridae) during Breeding Season Compared with Nonbreeding Season

Animals, 2021
The Libyan jird (Meriones libycus, 1823) is a wild desert rodent that is a seasonal breeder species adapted to breed when the environmental conditions can satisfy the energy and hydrous requirements of pregnant and nursing females to ensure that births ...
Radia Boufermes, Mansouria Belhocine, Zaina Amirat, Farida Khammar   +3 more
doaj   +2 more sources

Significance of FSHR and LHCGR gene polymorphisms on clinical outcomes in gonadotropin-releasing hormone antagonist protocol with freeze-all strategy: A case-control study

International Journal of Reproductive BioMedicine
Background: Follicle-stimulating hormone receptor (FSHR) and luteinizing hormone/choriogonadotropin receptor (LHCGR) are integral to ovarian function, facilitating follicle development and maturation through their respective hormonal interactions.
Jayesh Amin, Naga Sandhya Alle, Ami Patel, Bansi Prajapathi, Paresh Makwana, Jaya Prakash, Kota Murali Krishna   +6 more
doaj   +2 more sources

Post-trigger luteinizing hormone concentration to positively predict oocyte yield in the antagonist protocol and its association with genetic variants of LHCGR

Journal of Ovarian Research, 2023
Background The concentration of human chorionic gonadotropin (hCG)/ luteinizing hormone (LH) after triggering is generally accepted as a predictor of the normal ovarian response to the trigger, but few studies have explored the distribution model of ...
Hao Jin, Haiyan Yang, Jiujia Zheng, Jiechun Zhou, Rong Yu   +4 more
doaj   +2 more sources

MeCP2 duplication causes hyperandrogenism by upregulating LHCGR and downregulating RORα [PDF]

Cell Death & Disease, 2021
AbstractDuplication of MECP2 (methyl-CpG-binding protein 2) gene causes a serious neurological and developmental disorder called MECP2 duplication syndrome (MDS), which is usually found in males. A previous clinical study reported that MDS patient has precocious puberty with hyperandrogenism, suggesting increased MeCP2 may cause male hyperandrogenism ...
Yu-Meng Wang, Yu Wu, Yu-Fang Zheng, Hong-Yan Wang   +3 more
openaire   +3 more sources

Sp1 Regulates the Steroidogenic Genes and LHCGR Expression in Primary Human Luteinized Granulosa Cells [PDF]

, 2019
Luteinizing hormone and human chorionic gonadotropin (hCG) bind to the luteinizing hormone/chori23 onic gonadotropin receptor (LHCGR). LHCGR is required to maintain corpus luteum function but the mechanisms involved in the regulation of LHCGR in human ...
Nicola J. Winston (7925207), Carlos Stocco (7944737), Humberto Scoccia (7944773), Scott Convissar (7944770), Alberuni M. Zamah (7925198), Michelle A. Fierro (7925204)   +5 more
core   +4 more sources

由LHCGR基因杂合突变(M398T)所致家族性男性限性性早熟

Zhongshan Daxue xuebao. Yixue kexue ban, 2012
【目的】 总结由LHCGR基因激活性杂合突变导致的家族性男性限性性早熟(FMPP),提高临床医生对该病的诊治水平?【方法】 报道3例经LHCGR基因突变分析确诊的FMPP病例,并对相关文献进行复习?【结果】 病例1和病例3均为5岁男童,因外生殖器增大伴生长加速来诊?经相关检查临床诊断为外周性同性性早熟,其中,病例1有明显的家族史,4代中有6人(包括病例1的父亲,即病例2)有类似病史,成年身高在155 ~ 164.5 cm?LHCGR基因检测发现3例均存在LHCGR基因第11外显子相同的杂合点突变:c ...
doaj   +1 more source

Integrated Genomic, Transcriptomic, and Circulating Biomarkers Predict Benefit to Immune Checkpoint Inhibitor Plus Chemotherapy in Advanced Non-Small Cell Lung Cancer. [PDF]

MedComm (2020)
This multi‐omics study identified biomarkers associated with clinical benefit from first‐line ICI plus chemotherapy in advanced NSCLC. LRP1B mutations and high IL24 expression correlated with longer progression‐free survival, whereas FBXW7 mutations, high SPP1 or LHCGR expression, and on‐treatment ctDNA positivity were associated with poor prognosis ...
Li L, Han D, Zhang X, Zhou H, Li J, Tian T, Bai R, Xu K, Xu Y, He C, Xu L, Wang H, Tang H, Wei S, Li J, He R, Niu S, Gao X, Wang F, Jing Q, Yin J, Xu L, Xu L, Zhang ZH.   +23 more
europepmc   +2 more sources

Expression and function of the luteinizing hormone choriogonadotropin receptor in human endometrial stromal cells

Scientific Reports, 2022
The human luteinising hormone choriogonadotropin receptor (LHCGR) is a G-protein coupled receptor activated by both human chorionic gonadotropin (hCG) and luteinizing hormone (LH), two structurally related gonadotropins with essential roles in ovulation ...
O. N. Mann, C.-S. Kong, E. S. Lucas, J. J. Brosens, A. C. Hanyaloglu, P. J. Brighton   +5 more
doaj   +1 more source