Results 101 to 110 of about 12,270 (235)
Furin‐Mediated Cleavage of Zona Pellucida Proteins Is Essential for Oocyte Development
MedComm, Volume 6, Issue 12, December 2025.The furin cleavage site mutation leads to a failure in transmembrane transport process of non‐modified ZP2 protein. This unsuccessful ZP2 secretion might result in the decreased expression of exocytosis complex SNAREs, which further induces oocyte apoptosis via p53 pathway and PI3K signaling.
Tiechao Ruan +15 more
wiley +1 more source
PLoS Genetics, 2015 Genome wide association studies (GWAS) have revealed 11 independent risk loci for polycystic ovary syndrome (PCOS), a common disorder in young women characterized by androgen excess and oligomenorrhea.
Michelle R Jones +8 more
doaj +1 more source
The Pathogenic TSH β-Subunit Variant C105Vfs114X Causes a Modified Signaling Profile at TSHR [PDF]
, 2019 1) Background: Central congenital hypothyroidism (CCH) is a rare endocrine disorder that can be caused by mutations in the β-subunit of thyrotropin (TSHB).
Biebermann, Heike +6 more
core +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +206 more
wiley +1 more source
Slovenian Veterinary Research, 2017 Failure to become pregnant is the primary reason for a dairy cow to be culled from the production herd. A cow that is cycling normally, with no reproductive abnormalities, but has failed to conceive after at least three successive inseminations may ...
Korhan Arslan +5 more
doaj +1 more source
Cell Proliferation, Volume 58, Issue 12, December 2025.We compiled a comprehensive set of ZGA genes from mice, humans, pigs, bovines and goats, demonstrating the cross‐species conservation. An interpretable machine learning model, based on k‐mer core features, accurately predicted ZGA genes, revealing abundant and intricate six‐base sequence‐specific patterns and potential binding TFs.
Jixiang Xing +7 more
wiley +1 more source
Health Science Reports, Volume 8, Issue 11, November 2025.ABSTRACT Background and Objective This study employed Mendelian randomization (MR) to investigate the causal relationships between 4907 circulating proteins and hyperlipidemia, with the aim of identifying potential drug targets. Methods Instrumental variables were derived from genome‐wide association study (GWAS) data on 4907 circulating proteins ...
Hui Cheng, Dayuan Zhong
wiley +1 more source
Hyperprolactinemia induced by hCG leads to metabolic disturbances in female mice [PDF]
, 2016 The metabolic syndrome is a growing epidemic; it increases the risk for diabetes, cardiovascular disease, fatty liver, and several cancers. Several reports have indicated a link between hormonal imbalances and insulin resistance or obesity.
Bonaventura, Maria Marta +7 more
core +1 more source
Veterinary Medicine and Science, 2020 This study investigated the variations of the nucleotide sequences and ovarian expression levels of genes related to follicular development and atresia in prolific Jintang black goats and nonprolific Tibetan goats.
Xiang‐Dong Zi +4 more
doaj +1 more source
ZW and XY Sex Chromosomes Drive Rapid and Distinctive Evolution of Sex‐Biased Gene Expression
Molecular Ecology, Volume 34, Issue 22, November 2025.ABSTRACT Cichlids are a textbook model system of adaptive radiation and a fascinating example of rapid sex chromosome evolution. Yet in these fish, as in most other taxa, the mechanisms causing sex chromosome turnover and the subsequent impact thereof are unknown.
Kevin Hsiung +2 more
wiley +1 more source