Quantitative proteomic analysis of pathological and physiological ovarian aging: model evaluation, molecular mechanisms, and identification of early biomarkers and therapeutic targets. [PDF]
J Ovarian ResBai M +7 more
europepmc +1 more source
Investigating the causal relationship of lipid metabolism in polycystic ovary syndrome: a Mendelian randomization study on the regulatory role of 3-Hydroxybutyrate in gene expression. [PDF]
Front Med (Lausanne)Xu J +5 more
europepmc +1 more source
Morinda officinalis polysaccharides activate the SIRT1/PGC-1α pathway to reduce oxidative damage in Leydig TM3 cells. [PDF]
Sci RepFu M +5 more
europepmc +1 more source
A Rare Cause of Primary Amenorrhea: LHCGR Gene Mutations
European Journal of Obstetrics, Gynecology and Reproductive Biology, 2022 The luteinizing hormone/choriogonadotropin receptor (LHCGR) plays a critical role in sexual differentiation and reproductive functions in men and women. Inactivating mutations in this gene lead to Leydig cell hypoplasia (LCH), and cause disorders of sex development (DSD) in patients with 46,XY.
Amine Aktar Karakaya +2 more
exaly +5 more sources
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Luman Regulates the Activity of the LHCGR Promoter
Research in Veterinary Science, 2023Testosterone in male mammals is mainly secreted by testicular Leydig cells, and its secretion process is regulated by the hypothalamic-pituitary-gonadal axis. After receiving the luteinizing hormone (LH) stimulus signal, the lutropin/choriogonadotropin receptor (LHCGR) on the Leydig cell membrane transfers the signal into the cell and finally increases
Guangwen Yin +2 more
exaly +3 more sources
Associations of FSHR and LHCGR Gene Variants With Ovarian Reserve and Clinical Pregnancy Rates
Reproductive BioMedicine Online, 2021Are there any associations between the variants of FSHR c.2039 G>A (p. Ser680Asn, rs6166) and LHCGR c.935A>G (p. Asn312Ser, rs2293275) and ovarian reserve, ovarian response, clinical pregnancy rate and POSEIDON group?A total of 210 infertile women were enrolled in this prospective study. The gene variants were analysed by the Sanger method.
Qun Lv, Xiaoqi Liu
exaly +3 more sources
Molecular and Cellular Endocrinology, 2016 Gonadotropin signaling classically involves proliferative, steroidogenic and apoptotic stimuli. In this study, we used the human granulosa cell line hGL5 to demonstrate how follicle-stimulating hormone (FSH) and luteinizing hormone (LH) differently ...
Livio Casarini +2 more
exaly +2 more sources
Variants in DENND1A and LHCGR are associated with endometrioid adenocarcinoma
Gynecologic Oncology, 2012The aim of this study was to explore the polycystic ovary syndrome (PCOS) related single nucleotide polymorphisms (SNPs) rs13405728 (in gene LHCGR), rs13429458 (in gene THADA) and rs2479106 (in gene DENND1A) in women with endometrial carcinoma.We conducted a case-control study comprising 96 Han Chinese women with endometrial carcinoma, and 192 healthy ...
Zhenyan, Wang +7 more
openaire +2 more sources