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“Been Hit Twice”: A Novel Bi-Allelic Heterozygous Mutation in LHCGR [PDF]
Journal of Assisted Reproduction and Genetics, 2014 The pituitary and placental glycoprotein hormone receptors belong to the G-protein-coupled receptor (GPCR) superfamily that contains seven transmembrane helices [1, 2]. Of these, the human luteinizing hormone/chorionic gonadotropin receptor (LHCGR) binds two structurally related hormones: luteinizing hormone (LH) and human chorionic gonadotropin (hCG),
T Rajendra Kumar
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miRNA-592 Is Downregulated and May Target LHCGR in Polycystic Ovary Syndrome Patients
Reproductive Biology, 2015The polycystic ovary syndrome (PCOS) is an endocrine disorder mainly associated with infertility. Abnormal regulation of relevant genes is required for follicular development in PCOS. In the current study, the expression of serum miRNAs of PCOS patients was explored using miRNA array followed by qRT-PCR assays.
Shang-Wei Li, Shan Luo
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Mapping of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) to chicken chromosome 3 [PDF]
Animal Genetics, 2001 Source/description: The chicken luteinizing hormone/choriogonadotropin receptor gene has been cloned and sequenced. To produce markers for linkage mapping genomic DNA sequence from exon 7 to exon 9 including the intervening introns and exon was cloned and sequenced (EMBL accession number AJ289775).
Ge, SF +5 more
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Mechanism underlying the stimulation by IGF-1 of LHCGR expression in porcine granulosa cells
Theriogenology, 2021IGF-1 plays important roles in mammalian fertility by promoting cell growth and increasing steroid hormone secretion. Although IGF-1 significantly upregulated luteinizing hormone/choriogonadotropin receptor (LHCGR) gene expression in granulosa cells in a previous study, the mechanism was unclear. The present experiment was designed to primarily explore
Ying, Han +4 more
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Pathology - Research and Practice, 2019
In addition to its critical role during pregnancy, human chorionic gonadotropin (hCG) has been shown to be expressed by various tumor types. Recent studies have similarly documented the presence of the luteinizing hormone (LH)/hCG receptor (LHCGR) in a variety of nongonadal organs; however, its clinicopathological significance in ovarian cancer remains
Yuanyuan Zhong +7 more
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In addition to its critical role during pregnancy, human chorionic gonadotropin (hCG) has been shown to be expressed by various tumor types. Recent studies have similarly documented the presence of the luteinizing hormone (LH)/hCG receptor (LHCGR) in a variety of nongonadal organs; however, its clinicopathological significance in ovarian cancer remains
Yuanyuan Zhong +7 more
openaire +2 more sources
Molecular Biology Reports, 2013
Luteinizing hormone/choriogonadotropin receptor (LHCGR) gene, potentially related to reproductive traits in chickens, was genotyped by using the Pooled DNA Sequencing, PCR-SSCP and Directing Sequencing techniques. 306 Erlang Mountain chickens form one line (SD03, a line that has been selected for egg quality from a local chicken breed in Sichuan ...
Qing Zhu, Long Zhang, Di Yan Li
exaly +3 more sources
Luteinizing hormone/choriogonadotropin receptor (LHCGR) gene, potentially related to reproductive traits in chickens, was genotyped by using the Pooled DNA Sequencing, PCR-SSCP and Directing Sequencing techniques. 306 Erlang Mountain chickens form one line (SD03, a line that has been selected for egg quality from a local chicken breed in Sichuan ...
Qing Zhu, Long Zhang, Di Yan Li
exaly +3 more sources
Cytogenetics and Cell Genetics, 2008
Probes corresponding to human and porcine LH (luteinizing hormone) receptor cDNA were used for in situ hybridization to human chromosomes. This allowed us to assign the LH receptor gene to chromosome 2p21.
M F, Rousseau-Merck +5 more
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Probes corresponding to human and porcine LH (luteinizing hormone) receptor cDNA were used for in situ hybridization to human chromosomes. This allowed us to assign the LH receptor gene to chromosome 2p21.
M F, Rousseau-Merck +5 more
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Correlation between LHCGR and NR5A1 genes polymorphism and male infertility risk
Actas Urológicas Españolas (English Edition)Infertility is one of the important phenomena in human reproduction. Genetic factors are the most important cause of male infertility. Here, we aimed to investigate the correlation between idiopathic male infertility and SNPs of the LHCGR (rs2293275) and NR5A1 (rs1057517779) genes in the Iranian-Azeri population.This case-control study consisted of 100
M, Behvarz +4 more
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Regulation and localization of LHCGR protein in the human ovary
Fertility and Sterility, 2013Y. Yung +5 more
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