Results 171 to 180 of about 69,838 (265)

Hj‐aggregates of quinoline‐fused boron‐dipyrromethene nanoparticles for near‐infrared dualmodal photodynamic and photothermal therapy

open access: yesSmart Molecules, EarlyView.
A novel quinoline‐fused cyclic pyrrole is synthesized via lithium diisopropylamide‐catalyzed [3 + 2] cyclization, enabling the construction of a symmetrical boron‐dipyrromethene photosensitizer that forms Hj‐aggregates upon nanoparticle encapsulation.
Bo Zhang   +6 more
wiley   +1 more source

Harnessing the nonthermal effects of ultrasound for cancer treatment: From mechanisms to applications

open access: yesSmart Molecules, EarlyView.
Nonthermal ultrasound transforms acoustic energy into diverse therapeutic bioeffects through cavitation, mechanical stimulation, and physicochemical activation. This review discusses how acoustic parameters, biological mechanisms, and responsive materials interact to influence nonthermal ultrasound‐enabled cancer therapies. Mechanism‐guided engineering
Liu Wang   +5 more
wiley   +1 more source

AI‐enabled engineering of hesperidin/ursodeoxycholic acid nanomedicine for synergistic treatment of drug‐induced liver injury

open access: yesSmart Molecules, EarlyView.
An AI‐driven framework integrating disease‐network analysis, direction‐aware molecular screening, and carrier‐free co‐assembly engineering enables nanomedicine design. The dual‐constraint deep learning model predicts API–target affinity and regulatory direction to prioritize complementary APIs.
Kai Xiao   +14 more
wiley   +1 more source

Boron‐embedded multifunctional nanoplatform toward potential combined boron neutron capture therapy and immunomodulation in glioma

open access: yesSmart Molecules, EarlyView.
A brain‐targeting multifunctional nanoplatform (DM&Ce6@COF‐Ang) was engineered by employing boron‐enriched APTES‐COF‐1 as both the therapeutic boron agent and the nanocarrier co‐delivery of DMXAA and Ce6. This nanoplatform achieved synergistic tumor‐specific boron delivery, real‐time pharmacokinetic monitoring, and immunomodulation.
Yiming Liu   +13 more
wiley   +1 more source

Teaching Enjoyment and Vitality as Mediators of Cognitive Flexibility and Reflective Teaching in EFL Teachers: A Mixed‐Methods Serial Mediation Analysis

open access: yesTESOL Quarterly, EarlyView.
Abstract Reflective teaching (RT) is influenced by a range of cognitive, pedagogical, and psycho‐affective factors in second/foreign language (L2) education. However, empirical evidence on the influence of psycho‐affective variables on teachers' reflectivity remains limited.
Lili Qin   +2 more
wiley   +1 more source

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