Results 31 to 40 of about 24,456 (214)

The Vulnerable Subject

open access: yesSocieties, 2019
Academic freedom is formally supported but often challenged, through activities like no-platforming and through a sentiment of sensitivity and an understanding that ideas can be harmful.
Stuart Waiton
doaj   +1 more source

Mixed opinions: public attitudes towards the welfare state in Poland

open access: yesRuch Prawniczy, Ekonomiczny i Socjologiczny, 2022
This paper examines public opinion in Poland towards welfare policies and structures. We start by outlining the main research into welfare state models, in particular drawing on the welfare state typologies of Esping-Andersen.
Gavin Rae, Katarzyna Piotrowska
doaj   +1 more source

From Liberation to Liberalization [PDF]

open access: yesInterventions, 2015
Under colonial and then apartheid rule, Johannesburg has long endeavoured to deny the traces of its own geopolitical development. Promoting itself as the ‘ultimate city of the present’ (Palestrant 1986, 7), incessant cycles of urban renewal have ensured it has always boasted the latest in western metropolitan design, all the while dismissing any ...
openaire   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

De la responsabilidad social en la sociedad de riesgo:Más allá de la libertad de ser empresarios de sí mismos

open access: yesRevista Latinoamericana de Bioética, 2012
La reproducción neoliberal de la forma-empresa hacia el ámbito de la intimidad del sujeto que se consagra como "empresario de sí mismo" en un espacio de riesgos, de acuerdo con Foucault, obedece a cambios impredecibles e intempestivos; a un "medio ...
Wilmar Peña Collazos
doaj  

Liberal and Conservative Approach to the Poor Students’ Education in the USA

open access: yesBulletin of the Transilvania University of Braşov: Series VII: Social Sciences, Law, 2020
This paper aims at outlining the reactions to Coleman`s 1966 report, `Equality of education regarding the gap between the scores achieved by the rich and poor students in the USA at the standardized tests which generated antagonist educational agendas ...
Lucian Radu
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

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