Results 71 to 80 of about 2,167,425 (344)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Liberating the Liberated

open access: yes, 2019
This volume examines the formation and development of Śaiva tantric funerary practices (antyeṣṭi) and rituals of post-mortem ancestor worship (śrāddha) as preserved in the earliest extant strata of textual sources. These tantric scriptures and ritual manuals of the Śaiva Siddhānta cover a period from about the 5th to the 12th century CE.
openaire   +3 more sources

Why the Cameron-Clegg coalition will be a shock to both Tory and Liberal Democrat voters [PDF]

open access: yes, 2010
There has been intensive speculation about how Conservative and Liberal Democrat voters will react to the coalition government cemented in their name.
Norris, Pippa
core  

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Alcalá Zamora: un republicano demócrata y un cristiano

open access: yesHispania Sacra, 2012
Este trabajo quiere presentar a un cristiano, que amó la libertad, creyó en ella y trabajó para que llegara a todos por la vía de la justicia y del respeto a la ley, que resuelve dificultades y conflictos, reconociendo al otro igual dignidad y respeto y ...
Cristóbal Robles Muñoz
doaj   +1 more source

Reinhold Niebuhr’s Christian realism/ Christian idealism [PDF]

open access: yes, 2007
The foregoing quip captures a realization that came to the young Reinhold Niebuhr in the 192os and that turned the liberal Christian pastor away from pacifism and toward a more realist ethic of politics.
McKeogh, Colm
core   +1 more source

A Liberal Anti-Porn Feminism? [PDF]

open access: yes, 2018
In the 1980s and 1990s, a series of attempts were made to put into U.S. law a civil rights ordinance that would make it possible to sue the makers and distributors of pornography for doing so (under certain conditions).
Davies, Alex
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Liberal – Liberalismo

open access: yesLer História, 2008
The history of the words liberal and liberalism and the usages that were made in the Portuguese context share, as expected, many of the lines that are detectable in other scenarios.
Nuno Gonçalo Monteiro
doaj   +1 more source

Liberal education in crisis? [PDF]

open access: yes, 2014
It is argued that the plea for rational inquiry devoted to wisdom is not Eurocentric in ...
Maxwell, N
core  

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