Results 81 to 90 of about 1,923,934 (309)

Political Parties and Web 2.0: The Liberal Democrat Perspective [PDF]

, 2010
Political parties have been criticised for their limited use of interactivity via their Internet presences, largely it is suggested because they seek to control their online messages.
Jackson, Nigel, Lilleker, Darren, Pack, Mark   +2 more
core   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Radical liberal values-based practice. [PDF]

, 2011
Values based practice is a radical view of the place of values in medicine which develops from a philosophical analysis of values, illness and the role of ethical principles. It denies two attractive and traditional views of medicine: that diagnosis is a
Beauchamp, Beauchamp, Boorse, Fulford, Fulford, Gascoigne, Hare, Kendell, Macklin, Rubin, Sadler, Szasz, Thornton, Thornton, Wakefield, Wakefield   +15 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The Belarus-Poland migrant crisis

The European Journal of Humour Research
The migrant crisis on the Polish-Belarusian and Lithuanian-Belarusian borders has resulted in border crossing restrictions and the construction of walls separating Poland and Lithuania from Belarus.
Anastasiya Fiadotava, Władysław Chłopicki   +1 more
doaj   +1 more source

A multicentre randomised controlled trial of Transfusion Indication Threshold Reduction on transfusion rates, morbidity and health-care resource use following cardiac surgery (TITRe2)

Health Technology Assessment, 2016
Background: Uncertainty about optimal red blood cell transfusion thresholds in cardiac surgery is reflected in widely varying transfusion rates between surgeons and cardiac centres.
Barnaby C Reeves, Katie Pike, Chris A Rogers, Rachel CM Brierley, Elizabeth A Stokes, Sarah Wordsworth, Rachel L Nash, Alice Miles, Andrew D Mumford, Alan Cohen, Gianni D Angelini, Gavin J Murphy, on behalf of the TITRe2 investigators   +12 more
doaj   +1 more source

COPING WITH THE “NIMBY SYNDROME”: POLITICAL ISSUES RELATED TO THE BUILDING OF BIG INFRASTRUCTURES IN LIBERAL DEMOCRACY COUNTRIES

Security and Defence Quarterly, 2019
The location and building of big hazardous infrastructures is a typical feature of the modernization process, in all countries and epochs. Since they are usually useful for a large region but their impact is very localized, the people living around the ...
Agostino MASSA
doaj   +1 more source

Tradition, Authority and Dialogue: Arendt and Alexander on Education [PDF]

, 2018
In this paper I discuss two attempts to challenge mainstream liberal education, by Hannah Arendt and by contemporary Israeli philosopher Hanan Alexander. Arendt and Alexander both identify problems in liberal-secular modern politics and present
Snir, Itay
core   +2 more sources